Dynamic thiol-disulfide homeostasis is disturbed in hepatitis B virus-related chronic hepatitis and liver cirrhosis
Yıl: 2018 Cilt: 48 Sayı: 5 Sayfa Aralığı: 985 - 992 Metin Dili: İngilizce DOI: 10.3906/sag-1803-135 İndeks Tarihi: 21-06-2019
Dynamic thiol-disulfide homeostasis is disturbed in hepatitis B virus-related chronic hepatitis and liver cirrhosis
Öz: Background/aim: Thiol-disulfide homeostasis is an important antioxidant defense mechanism. This study was conducted to investigatedynamic thiol-disulfide homeostasis in patients with hepatitis B virus-related chronic hepatitis and liver cirrhosis.Materials and methods: Seventy-one treatment-naive patients with chronic hepatitis B (CHB), 50 patients with hepatitis B virusassociated liver cirrhosis, and 45 healthy controls were included in the study. Serum total and native thiol concentrations and serumdisulfide concentrations were measured using an automated method.Results: Mean serum total thiol concentrations in the control, CHB, and cirrhosis groups were 481.64 ± 37.87 µmol/L, 438.50 ± 71.35µmol/L, and 358.07 ± 80.47 µmol/L, respectively (P < 0.001), and mean serum native thiol concentrations in the control, CHB, andcirrhosis groups were 452.92 ± 36.43 µmol/L, 400.16 ± 65.92 µmol/L, and 328.15 ± 74.91 µmol/L, respectively (P < 0.001). Mean serumdisulfide concentrations in the control, CHB, and cirrhosis groups were 14.38 ± 3.38 µmol/L, 19.19 ± 6.16 µmol/L, and 14.98 ± 5.53µmol/L, respectively (P < 0.001). There was a progressive decrease in both mean serum native and total thiol concentrations parallel tothe liver fibrosis stage.Conclusion: : Thiol-disulfide homeostasis is disturbed in patients with hepatitis B virus-related chronic hepatitis and liver cirrhosis.
Anahtar Kelime: Konular:
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | Dertli R, Keskin M, biyik m, ATASEVEN H, Polat H, DEMİR A, oltulu p, NEŞELOĞLU S, EREL O, ASIL M (2018). Dynamic thiol-disulfide homeostasis is disturbed in hepatitis B virus-related chronic hepatitis and liver cirrhosis. , 985 - 992. 10.3906/sag-1803-135 |
| Chicago | Dertli Ramazan,Keskin Muharrem,biyik murat,ATASEVEN Hüseyin,Polat Hakki,DEMİR ALİ,oltulu pembe,NEŞELOĞLU Salim,EREL Ozcan,ASIL MEHMET Dynamic thiol-disulfide homeostasis is disturbed in hepatitis B virus-related chronic hepatitis and liver cirrhosis. (2018): 985 - 992. 10.3906/sag-1803-135 |
| MLA | Dertli Ramazan,Keskin Muharrem,biyik murat,ATASEVEN Hüseyin,Polat Hakki,DEMİR ALİ,oltulu pembe,NEŞELOĞLU Salim,EREL Ozcan,ASIL MEHMET Dynamic thiol-disulfide homeostasis is disturbed in hepatitis B virus-related chronic hepatitis and liver cirrhosis. , 2018, ss.985 - 992. 10.3906/sag-1803-135 |
| AMA | Dertli R,Keskin M,biyik m,ATASEVEN H,Polat H,DEMİR A,oltulu p,NEŞELOĞLU S,EREL O,ASIL M Dynamic thiol-disulfide homeostasis is disturbed in hepatitis B virus-related chronic hepatitis and liver cirrhosis. . 2018; 985 - 992. 10.3906/sag-1803-135 |
| Vancouver | Dertli R,Keskin M,biyik m,ATASEVEN H,Polat H,DEMİR A,oltulu p,NEŞELOĞLU S,EREL O,ASIL M Dynamic thiol-disulfide homeostasis is disturbed in hepatitis B virus-related chronic hepatitis and liver cirrhosis. . 2018; 985 - 992. 10.3906/sag-1803-135 |
| IEEE | Dertli R,Keskin M,biyik m,ATASEVEN H,Polat H,DEMİR A,oltulu p,NEŞELOĞLU S,EREL O,ASIL M "Dynamic thiol-disulfide homeostasis is disturbed in hepatitis B virus-related chronic hepatitis and liver cirrhosis." , ss.985 - 992, 2018. 10.3906/sag-1803-135 |
| ISNAD | Dertli, Ramazan vd. "Dynamic thiol-disulfide homeostasis is disturbed in hepatitis B virus-related chronic hepatitis and liver cirrhosis". (2018), 985-992. https://doi.org/10.3906/sag-1803-135 |
| APA | Dertli R, Keskin M, biyik m, ATASEVEN H, Polat H, DEMİR A, oltulu p, NEŞELOĞLU S, EREL O, ASIL M (2018). Dynamic thiol-disulfide homeostasis is disturbed in hepatitis B virus-related chronic hepatitis and liver cirrhosis. Turkish Journal of Medical Sciences, 48(5), 985 - 992. 10.3906/sag-1803-135 |
| Chicago | Dertli Ramazan,Keskin Muharrem,biyik murat,ATASEVEN Hüseyin,Polat Hakki,DEMİR ALİ,oltulu pembe,NEŞELOĞLU Salim,EREL Ozcan,ASIL MEHMET Dynamic thiol-disulfide homeostasis is disturbed in hepatitis B virus-related chronic hepatitis and liver cirrhosis. Turkish Journal of Medical Sciences 48, no.5 (2018): 985 - 992. 10.3906/sag-1803-135 |
| MLA | Dertli Ramazan,Keskin Muharrem,biyik murat,ATASEVEN Hüseyin,Polat Hakki,DEMİR ALİ,oltulu pembe,NEŞELOĞLU Salim,EREL Ozcan,ASIL MEHMET Dynamic thiol-disulfide homeostasis is disturbed in hepatitis B virus-related chronic hepatitis and liver cirrhosis. Turkish Journal of Medical Sciences, vol.48, no.5, 2018, ss.985 - 992. 10.3906/sag-1803-135 |
| AMA | Dertli R,Keskin M,biyik m,ATASEVEN H,Polat H,DEMİR A,oltulu p,NEŞELOĞLU S,EREL O,ASIL M Dynamic thiol-disulfide homeostasis is disturbed in hepatitis B virus-related chronic hepatitis and liver cirrhosis. Turkish Journal of Medical Sciences. 2018; 48(5): 985 - 992. 10.3906/sag-1803-135 |
| Vancouver | Dertli R,Keskin M,biyik m,ATASEVEN H,Polat H,DEMİR A,oltulu p,NEŞELOĞLU S,EREL O,ASIL M Dynamic thiol-disulfide homeostasis is disturbed in hepatitis B virus-related chronic hepatitis and liver cirrhosis. Turkish Journal of Medical Sciences. 2018; 48(5): 985 - 992. 10.3906/sag-1803-135 |
| IEEE | Dertli R,Keskin M,biyik m,ATASEVEN H,Polat H,DEMİR A,oltulu p,NEŞELOĞLU S,EREL O,ASIL M "Dynamic thiol-disulfide homeostasis is disturbed in hepatitis B virus-related chronic hepatitis and liver cirrhosis." Turkish Journal of Medical Sciences, 48, ss.985 - 992, 2018. 10.3906/sag-1803-135 |
| ISNAD | Dertli, Ramazan vd. "Dynamic thiol-disulfide homeostasis is disturbed in hepatitis B virus-related chronic hepatitis and liver cirrhosis". Turkish Journal of Medical Sciences 48/5 (2018), 985-992. https://doi.org/10.3906/sag-1803-135 |
