Effects of Resveratrol on Inflammation and Apoptosis After Experimental Spinal Cord Injury

Salim SENTURK, (Koç Üniversitesi, Hastanesi, Nöroşirürji Anabilim Dalı, İstanbul, Türkiye)
Mesut Emre YAMAN, (Memorial Hastanesi, Beyin Cerrahisi Kliniği, Ankara, Türkiye)
Hasan Emre AYDIN, (Dumlupınar Üniversitesi, Tıp Fakültesi, Beyin Cerrahisi Anabilim Dalı Kütahya, Türkiye)
Güven GÜNEY, (Hitit Üniversitesi, Çorum Eğitim ve Araştırma Hastanesi, Patoloji Kliniği, Çorum, Türkiye)
İsmail BOZKURT, (Çankırı Devlet Hastanesi, Beyin Cerrahisi Kliniği, Çankırı, Türkiye)
Kemal PAKSOY, (Kaçkar Devlet Hastanesi, Beyin Cerrahisi Kliniği, Rize, Türkiye)
Ahmet Atilla ABDIOGLU (Recep Tayyip Erdoğan Üniversitesi, Ortopedi Cerrahisi Anabilim Dalı, Rize, Türkiye)
Turkish Neurosurgery
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Yıl: 2018 Cilt: 28 Sayı: 6 Sayfa Aralığı: 889 - 896 Metin Dili: İngilizce DOI: 10.5137/1019-5149.JTN.21829-17.3 İndeks Tarihi: 24-06-2019

Effects of Resveratrol on Inflammation and Apoptosis After Experimental Spinal Cord Injury

Öz:
AIM: To determine the effects of resveratrol on inflammation and apoptosis after experimental spinal cord injury (SCI).MATERIAL and METHODS: Eighteen Sprague-Dawley rats were randomly divided into three groups. All groups underwent thoraciclaminectomy. The first group received no other intervention. The second and third groups suffered SCI via the aneurysm clipcompression method, and additionally the third group received resveratrol. After euthanizing the rats, immunohistochemical analysisand biochemical parameters of tumor necrosis factor alpha (TNF-α) and interleukin (IL)-1β were measured.RESULTS: The resveratrol group had statistically significant lower levels of TNF-α, IL -1β, and terminal deoxynucleotidyl transferasemediated dUTP nick-end labeling (TUNEL) positive cells and higher number of glial and motor neuron cells.CONCLUSION: Resveratrol proves to have remarkable neuroprotective effects on SCI in an experimental model in addition to itsproven cardioprotective effects.
Anahtar Kelime:

Konular: Cerrahi
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA senturk s, YAMAN M, AYDIN H, GÜNEY G, Bozkurt I, paksoy k, ABDIOGLU A (2018). Effects of Resveratrol on Inflammation and Apoptosis After Experimental Spinal Cord Injury. , 889 - 896. 10.5137/1019-5149.JTN.21829-17.3
Chicago senturk salim,YAMAN Mesut Emre,AYDIN Hasan Emre,GÜNEY Güven,Bozkurt Ismail,paksoy kemal,ABDIOGLU Ahmet Atilla Effects of Resveratrol on Inflammation and Apoptosis After Experimental Spinal Cord Injury. (2018): 889 - 896. 10.5137/1019-5149.JTN.21829-17.3
MLA senturk salim,YAMAN Mesut Emre,AYDIN Hasan Emre,GÜNEY Güven,Bozkurt Ismail,paksoy kemal,ABDIOGLU Ahmet Atilla Effects of Resveratrol on Inflammation and Apoptosis After Experimental Spinal Cord Injury. , 2018, ss.889 - 896. 10.5137/1019-5149.JTN.21829-17.3
AMA senturk s,YAMAN M,AYDIN H,GÜNEY G,Bozkurt I,paksoy k,ABDIOGLU A Effects of Resveratrol on Inflammation and Apoptosis After Experimental Spinal Cord Injury. . 2018; 889 - 896. 10.5137/1019-5149.JTN.21829-17.3
Vancouver senturk s,YAMAN M,AYDIN H,GÜNEY G,Bozkurt I,paksoy k,ABDIOGLU A Effects of Resveratrol on Inflammation and Apoptosis After Experimental Spinal Cord Injury. . 2018; 889 - 896. 10.5137/1019-5149.JTN.21829-17.3
IEEE senturk s,YAMAN M,AYDIN H,GÜNEY G,Bozkurt I,paksoy k,ABDIOGLU A "Effects of Resveratrol on Inflammation and Apoptosis After Experimental Spinal Cord Injury." , ss.889 - 896, 2018. 10.5137/1019-5149.JTN.21829-17.3
ISNAD senturk, salim vd. "Effects of Resveratrol on Inflammation and Apoptosis After Experimental Spinal Cord Injury". (2018), 889-896. https://doi.org/10.5137/1019-5149.JTN.21829-17.3
APA senturk s, YAMAN M, AYDIN H, GÜNEY G, Bozkurt I, paksoy k, ABDIOGLU A (2018). Effects of Resveratrol on Inflammation and Apoptosis After Experimental Spinal Cord Injury. Turkish Neurosurgery, 28(6), 889 - 896. 10.5137/1019-5149.JTN.21829-17.3
Chicago senturk salim,YAMAN Mesut Emre,AYDIN Hasan Emre,GÜNEY Güven,Bozkurt Ismail,paksoy kemal,ABDIOGLU Ahmet Atilla Effects of Resveratrol on Inflammation and Apoptosis After Experimental Spinal Cord Injury. Turkish Neurosurgery 28, no.6 (2018): 889 - 896. 10.5137/1019-5149.JTN.21829-17.3
MLA senturk salim,YAMAN Mesut Emre,AYDIN Hasan Emre,GÜNEY Güven,Bozkurt Ismail,paksoy kemal,ABDIOGLU Ahmet Atilla Effects of Resveratrol on Inflammation and Apoptosis After Experimental Spinal Cord Injury. Turkish Neurosurgery, vol.28, no.6, 2018, ss.889 - 896. 10.5137/1019-5149.JTN.21829-17.3
AMA senturk s,YAMAN M,AYDIN H,GÜNEY G,Bozkurt I,paksoy k,ABDIOGLU A Effects of Resveratrol on Inflammation and Apoptosis After Experimental Spinal Cord Injury. Turkish Neurosurgery. 2018; 28(6): 889 - 896. 10.5137/1019-5149.JTN.21829-17.3
Vancouver senturk s,YAMAN M,AYDIN H,GÜNEY G,Bozkurt I,paksoy k,ABDIOGLU A Effects of Resveratrol on Inflammation and Apoptosis After Experimental Spinal Cord Injury. Turkish Neurosurgery. 2018; 28(6): 889 - 896. 10.5137/1019-5149.JTN.21829-17.3
IEEE senturk s,YAMAN M,AYDIN H,GÜNEY G,Bozkurt I,paksoy k,ABDIOGLU A "Effects of Resveratrol on Inflammation and Apoptosis After Experimental Spinal Cord Injury." Turkish Neurosurgery, 28, ss.889 - 896, 2018. 10.5137/1019-5149.JTN.21829-17.3
ISNAD senturk, salim vd. "Effects of Resveratrol on Inflammation and Apoptosis After Experimental Spinal Cord Injury". Turkish Neurosurgery 28/6 (2018), 889-896. https://doi.org/10.5137/1019-5149.JTN.21829-17.3
Sayfa Oluşturulma Tarihi
23-04-2024 8:3

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