Objective: In this study, we examined the patients’ characteristics, who underwent voiding cystourethrography(VCUG), in order to determine any selectivity for indication of this invasive method.Material and methods: After exclusion of indications of neurogenic bladder or antenatal hydronephrosisand control VCUGs, 159 VCUGs performed in our clinic within one year were evaluated. Patients are dividedinto three groups accoding to age. Clinical characteristic and findings of renal ultrasonography (US)and renal scintigraphy were examined.Results: Vesicoureteral reflux (VUR) was detected in 61 (38.3%) of 159 patients who underwent cystourethrographicexaminations, in 45.8% of the patients with a history of recurrent urinary tract infection (UTI),in 22.0% of the patients with pathological urinary system US without history of recurrent UTI. High-gradereflux rate was significantly more frequent in renal units with pathological US findings. Severe scar wassignificantly more frequent in renal units with high-grade reflux when compared to renal units without refluxand those with low-grade reflux. Predictive values of recurrent UTI, scarring status and pathological US forVUR were separately analyzed and seen that likelihood of indicating VUR was increased when all 3 riskfactors were assessed together.Conclusion: Vesicoureteral reflux is a problem in which diagnostic process and management strategyshould have to be considered in individualized manner for each patient. Before prescribing invasive VCUG,imaging urinary system by US and scintigraphy and determining whether there is recurrent UTI will improveselectivity and success of VCUG.