Objective: Psoriasis is frequently associated with comorbidities including metabolic syndrome and nonalcoholic fatty liver disease. Visfatin is an adipokine secreted from adipocytes of white adipose tissue and its high concentrations is known to be in a relationship with abdominal obesity and chronic inflamation. This study investigates serum levels of visfatin in patients with psoriasis therefore we consider how psoriasis is linked to metabolic syndrome and non alcoholic fatty liver disease. Method: In this study, we evaluated 80 psoriasis patients which are requested Canakkale Onsekiz Mart University, Faculty of Medicine, Dermatology Department outpatient clinic. They divided into 2 groups as patients with metabolic syndrome and without diagnosis of metabolic syndrome. A healthy control group, 40 people are also included. The body mass index, waist and hip circumference were calculated. The score of psoriasis area severity index, grade of non alcoholic fatty liver disease. Our patients are also undergo ultrasonografic liver screening. For quantification of the visfatin, ELISA based assay was used . Results: Visfatin levels were found istatistically higher in the healthy (without metabolic syndrome) psoriasis group versus control group (p<0.001). Neither healthy psoriasis patients nor psoriasis patients with metabolic syndrome, a significant difference could be observed both group (p=0,980). On the other hand the prevelance of the non alcoholic fatty liver disease has showed no difference between healthy controls and healthy psoriasis patients (p=0,469). Non alcoholic fatty liver disease and the severity of hepatosteatosis were determined significantly higher in psoriasis patients with metabolic syndrome (p<0,001). Conclusion: Prevalance of non alcholic fatty liver disease was observed to be higher in psoriasis patients. However there were no difference between controls and healthy psoriasis patients for prevalance of non alcholic fatty liver disease. Therefore we think that this result supports the metabolic syndrome and psoriasis relationship. Visfatin levels detected significantly higher in psoriasis patients independetly from metabolic syndrome and its components. These findings suggest that high visfatin levels might play role in chronic inflammation seen in psoriasis.