The Effects of Concomitant Giardia intestinalis Infection on Acute Gastrointestinal Toxicity in Rats Undergoing Pelvic Irradiation

Vardi, Nigar; ERKAL, Haldun Şükrü; AYCAN KAYA, Özlem Makbule; DOĞAN, ZÜMRÜT; ELİBOL, Ebru

The Effects of Concomitant Giardia intestinalis Infection on Acute Gastrointestinal Toxicity in Rats Undergoing Pelvic Irradiation

Zümrüt DOĞAN, (Adıyaman Üniversitesi, Tıp Fakültesi, Anatomi, Bölümü, Adıyaman, Türkiye)

Özlem Makbule AYCAN KAYA, (Mustafa Kemal Üniversitesi, Tıp Fakültesi, Parazitoloji Anabilim Dalı, Hatay, Türkiye)

Ebru ELİBOL, (Adıyaman Üniversitesi, Tıp Fakültesi, Histoloji ve Embriyoloji Anabilim Dalı, Adıyaman, Türkiye)

Nigar VARDI, (İnönü Üniversitesi, Tıp Fakültesi, Dahili Tıp Bilimleri Bölümü,(İngilizce) Tıbbi Farmakoloji Anabilim Dalı, Malatya, Türkiye)

Haldun Şükrü ERKAL (İnönü Üniversitesi, Tıp Fakültesi, Radyasyon Onkolojisi Anabilim Dalı, Malatya, Türkiye)

ACTA ONCOLOGICA TURCICA

1 0

Yıl: 2018 Cilt: 51 Sayı: 2 Sayfa Aralığı: 188 - 198 Metin Dili: İngilizce İndeks Tarihi: 26-03-2019

The Effects of Concomitant Giardia intestinalis Infection on Acute Gastrointestinal Toxicity in Rats Undergoing Pelvic Irradiation

Öz:

INTRODUCTION: Different types of pelvic cancer, such as cervical, endometrial, bladder and prostate, are normally treated by radical radiotherapy, which can be used both alone or in combination with surgery and/or chemotherapy. The aim of this study is to assess the effects of concomitant Giardia intestinalis infection on acute gastrointestinal toxicity in rats that have undergone pelvic irradiation. METHODS: The study group consisted of forty female 6-month-old Wistar rats with the weight of 250 g. The rats were divided into four groups containing ten rats in each group. The study groups are as follows: Group 1 contained rats not infected with Giardia intestinalis and not irradiated, Group 2 contained rats infected with Giardia intestinalis but not irradiated, Group 3 contained rats not infected with Giardia intestinalis but irradiated, Group 4 contained rats infected with Giardia intestinalis and radiated. For the day after the end of radiation, the number of stool pellets was counted, and the operation of weighing rats was performed, and they were sacrificed the following day. The intestinal tissues were taken for histological evaluation. RESULTS: A mucosal damage, such as villus shortening, atrophy of surface epithelium, crypt loss, as well as a decrease in the number of goblet cells of the group 3 and 4, was detected as a result of the light microscopic examination. CONCLUSION: As a result of the present study, the fact that concomitant Giardia intestinalis infection aggravates acute gastrointestinal toxicity in rats that have undergone pelvic irradiation has been verified.

Anahtar Kelime:

Konular: Onkoloji

Pelvik Radyoterapi Uygulanılan Sıçanlarda Akut Gastointestinal Toksisite Üzerine Giardi İntestinalis Enfeksiyonunun Etkileri

Öz:

GİRİŞ: Servikal, endometrial, mesane ve prostat gibi pelvik kanserin farklı türleri normalde ya sadece radikal radyoterapi ile yada cerrahi ve kemoterapi birlikte kombinasyon halinde tedavi edilebilir. Bu çalışmanın amacı, pelvik radyasyona maruz kalan sıçanlarda eşzamanlı Giardia intestinalis enfeksiyonunun akut gastrointestinal toksisite üzerine etkilerinin araştırılmasıdır. METOD: Çalışma grubu, 250 g ağırlığa sahip kırk adet 6 aylık dişi Wistar sıçandan oluşmaktadır. Sıçanlar, herbir grupta 10 adet sıçan olacak şekilde dört gruba ayrıldı. Çalışma grupları; Grup 1, Giardia intestinalis ile enfekte olmayan ve radyoterapi almayan sıçanlar, Grup 2, radyoterapi almamış, ancak Giardia intestinalis ile enfekte olan sıçanlar, Grup 3, Giardia intestinalis ile enfekte olmamış fakat radyoterapi almış sıçanlar, Grup 4'te hem Giardia intestinalis ile enfekte olan hemde radyoterapi alan sıçanlardan oluşmaktadır. Radyasyon bittikten sonraki gün, hayvan vücut ağırlıkları kayıtedildi ve dışkılama sıklığı hesaplandı. Ratlar perfore edilerek sakrifiye edildi, ince bağırsak dokuları histolojik inceleme için alındı. SONUÇ: Işık mikroskopik incelemesinin sonucu olarak, grup 3 ve 4 ‘te villus kısalması, yüzeyel epitelinde atrofi, kriptalarda kayıp gibi mukozal hasarlar ve goblet sayısında azalma tespit edildi. TARTIŞMA: Bu çalışmanın bir sonucu olarak, Giardia intestinalis enfeksiyonu ile eşzamanlı olarak pelvik radyoterapi uygulanması sıçanlarda akut gastrointestinal toksisiteyi arttırmıştır. zümrüt doğ

Anahtar Kelime:

Konular: Onkoloji

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	DOĞAN Z, AYCAN KAYA Ö, ELİBOL E, Vardi N, ERKAL H (2018). The Effects of Concomitant Giardia intestinalis Infection on Acute Gastrointestinal Toxicity in Rats Undergoing Pelvic Irradiation. , 188 - 198.
Chicago	DOĞAN ZÜMRÜT,AYCAN KAYA Özlem Makbule,ELİBOL Ebru,Vardi Nigar,ERKAL Haldun Şükrü The Effects of Concomitant Giardia intestinalis Infection on Acute Gastrointestinal Toxicity in Rats Undergoing Pelvic Irradiation. (2018): 188 - 198.
MLA	DOĞAN ZÜMRÜT,AYCAN KAYA Özlem Makbule,ELİBOL Ebru,Vardi Nigar,ERKAL Haldun Şükrü The Effects of Concomitant Giardia intestinalis Infection on Acute Gastrointestinal Toxicity in Rats Undergoing Pelvic Irradiation. , 2018, ss.188 - 198.
AMA	DOĞAN Z,AYCAN KAYA Ö,ELİBOL E,Vardi N,ERKAL H The Effects of Concomitant Giardia intestinalis Infection on Acute Gastrointestinal Toxicity in Rats Undergoing Pelvic Irradiation. . 2018; 188 - 198.
Vancouver	DOĞAN Z,AYCAN KAYA Ö,ELİBOL E,Vardi N,ERKAL H The Effects of Concomitant Giardia intestinalis Infection on Acute Gastrointestinal Toxicity in Rats Undergoing Pelvic Irradiation. . 2018; 188 - 198.
IEEE	DOĞAN Z,AYCAN KAYA Ö,ELİBOL E,Vardi N,ERKAL H "The Effects of Concomitant Giardia intestinalis Infection on Acute Gastrointestinal Toxicity in Rats Undergoing Pelvic Irradiation." , ss.188 - 198, 2018.
ISNAD	DOĞAN, ZÜMRÜT vd. "The Effects of Concomitant Giardia intestinalis Infection on Acute Gastrointestinal Toxicity in Rats Undergoing Pelvic Irradiation". (2018), 188-198.

APA	DOĞAN Z, AYCAN KAYA Ö, ELİBOL E, Vardi N, ERKAL H (2018). The Effects of Concomitant Giardia intestinalis Infection on Acute Gastrointestinal Toxicity in Rats Undergoing Pelvic Irradiation. ACTA ONCOLOGICA TURCICA, 51(2), 188 - 198.
Chicago	DOĞAN ZÜMRÜT,AYCAN KAYA Özlem Makbule,ELİBOL Ebru,Vardi Nigar,ERKAL Haldun Şükrü The Effects of Concomitant Giardia intestinalis Infection on Acute Gastrointestinal Toxicity in Rats Undergoing Pelvic Irradiation. ACTA ONCOLOGICA TURCICA 51, no.2 (2018): 188 - 198.
MLA	DOĞAN ZÜMRÜT,AYCAN KAYA Özlem Makbule,ELİBOL Ebru,Vardi Nigar,ERKAL Haldun Şükrü The Effects of Concomitant Giardia intestinalis Infection on Acute Gastrointestinal Toxicity in Rats Undergoing Pelvic Irradiation. ACTA ONCOLOGICA TURCICA, vol.51, no.2, 2018, ss.188 - 198.
AMA	DOĞAN Z,AYCAN KAYA Ö,ELİBOL E,Vardi N,ERKAL H The Effects of Concomitant Giardia intestinalis Infection on Acute Gastrointestinal Toxicity in Rats Undergoing Pelvic Irradiation. ACTA ONCOLOGICA TURCICA. 2018; 51(2): 188 - 198.
Vancouver	DOĞAN Z,AYCAN KAYA Ö,ELİBOL E,Vardi N,ERKAL H The Effects of Concomitant Giardia intestinalis Infection on Acute Gastrointestinal Toxicity in Rats Undergoing Pelvic Irradiation. ACTA ONCOLOGICA TURCICA. 2018; 51(2): 188 - 198.
IEEE	DOĞAN Z,AYCAN KAYA Ö,ELİBOL E,Vardi N,ERKAL H "The Effects of Concomitant Giardia intestinalis Infection on Acute Gastrointestinal Toxicity in Rats Undergoing Pelvic Irradiation." ACTA ONCOLOGICA TURCICA, 51, ss.188 - 198, 2018.
ISNAD	DOĞAN, ZÜMRÜT vd. "The Effects of Concomitant Giardia intestinalis Infection on Acute Gastrointestinal Toxicity in Rats Undergoing Pelvic Irradiation". ACTA ONCOLOGICA TURCICA 51/2 (2018), 188-198.