Objective: To determine the perceived social stigma and familial attitides and perception of sexuality in infertile couples attending infertility clinics.Materials and Methods: Infertile couples attending infertility clinics between the years of 2014 and 2015 were requested to complete detailed evaluationforms including questions related to the social stigma on their infertility, their familial attitudes, and perception of sexuality. Any partner of the infertilecouple accepting to enroll in the study was given the evaluation forms. Their scores related to answers and demographics, and parameters related toinfertility were analyzed.Results: A total 598 partners of infertile couples enrolled in the study, 58% represented 177 couples. Their infertility was primary in 98.3% and theduration of marriage and infertility was 9.81±5.58 and 9.76±5.53 years, respectively. The perception of social exclusion was present in 38% (p<0.001)of infertile couple, which was more significantly pronounced in female partners (p=0.013). Fifteen percent of the infertile couples thought themselvesas isolated in public and losing value in public (p<0.001). However, sixty percent of infertile couples thought that they would achieve a notable placein community after having a baby (p<0.001). Infertility was accepted as a reason of divorce in only 13% of infertile couples (p<0.001). The majority ofperticipnats, irrespective of sex, rejected that infertile women or men lost sexual appeal (86%; p<0.001).Conclusions: There is significant effect of infertility on familial attitudes and perception of sexuality of infertile couples. Unfortunately, there is significantnegative social stigma on infertile couples.