Yıl: 2018 Cilt: 18 Sayı: 4 Sayfa Aralığı: 657 - 663 Metin Dili: İngilizce DOI: 10.17098/amj.497499 İndeks Tarihi: 27-08-2019

Thiol/Disulphide Homeostasis Neutrophil Lymphocyte and Platelet Lymphocyte Ratio in Emergency Department Patients with Renal Colic

Öz:
Objectives: This study's aim is to investigate if using thiol/disulphide homeostasis parameters whichare oxidative stress markers together with Neutrophile‐Lymphocyte and Platelet‐Lymphocyte ratio(NLR, PLR) is diagnostically useful in the patients who present to the emergency department with renalcolic.Materials and Methods: The study was made prospectively with 75 patients who were admitted to theemergency department between 15.05.2018 and 01.10.2018 and 47 healthy subjects who were determinedas control group. Thiol/disulphide homeostasis parameters (thiol, disulphide, disulphide / native thiol,disulphide / total thiol, native thiol / total thiol) which are oxidative stress markers are measured by anew method which was developed by Erel and Neşelioğlu in the patient and control groups, also NLRand PLR were studied. These parameters were compared also between the patient groups with urinarystone disease and that without.Results: NLR, PLR, disulphide, disulphide /native thiol and disulphide /total thiol average values werefound significantly high (respectively p= 0.010, <0.001, <0.001, <0.001, 0.023, 0.012), but native thiol andtotal thiol average values were found significantly low (respectively p=0.018 and 0.001) in the patientgroup. Disulphide, disulphide /native thiol, NLR and PLR average values were found significantly high(respectively p <0.001, <0.001, <0.001, <0.001) in the patient group.Conclusion: Using NLR and PLR in renal colic diagnosis together with thiol/disulphide homeostasisparameters is useful for these patients to make a diagnosis.
Anahtar Kelime:

Konular: Genel ve Dahili Tıp Diş Hekimliği

Acil Serviste Renal Koliği Olan Hastalarda Tiyol/Disülfid Homeostazı Nötrofil Lenfosit ve Platelet Lenfosit Oranı

Öz:
Amaç: Bu çalışmanın amacı acil servise renal kolik nedeniyle başvuran hastalarda oksidatif stres markerlarından olan tiyol/disülfid homeostazı parametreleri ile Nötrofil‐Lenfosit ve Platelet‐Lenfosit oranlarının (NLO, PLO) beraber kullanımının tanı açısından yararlı olup olmadığını araştırmaktır. Materyal ve Metot: Çalışma 15.05.2018 ile 01.10.2018 tarihleri arasında acil servise başvuran ve çalışmaya alınan 75 hasta ve kontrol grubu olarak belirlenen 47 sağlıklı kişi ile prospektif olarak yapıldı. Erel ve Neşelioğlu tarafından yeni geliştirilen bir metot ile oksidatif stres belirteci olan tiyol/disülfid homeostaz parametreleri ( Tiyol, disülfid, disülfid / native tiyol, disüfid / total tiyol, native tiyol / total tiyol) ile NLO ve PLO hasta ve kontrol grubunda çalışıldı. Üriner taş hastalığı olan ve olmayanlar arasında bu parametreler karşılaştırıldı. Bulgular: Renal koliği olanlarda kontrol grubuna göre, NLO, PLO, disülfid, disülfid /native tiyol ve disülfid /total tiyol ortalama değerleri anlamlı derecede yüksek bulunurken (sırasıyla p= 0.010, <0.001, <0.001, <0.001, 0.023, 0.012), native tiyol ve total tiyol ortalama değerleri anlamlı derecede düşük bulundu (sırasıyla p=0.018 ve 0.001). Üriner taş hastalığı olan grupta olmayan gruba göre disülfid, disülfid /native tiyol, NLO ve PLO ortalama değerleri anlamlı derecede yüksek bulundu (sırasıyla p <0.001, <0.001, <0.001, <0.001). Sonuç: NLO ve PLO ile tiyol/disülfid homeostaz parametrelerinin renal kolik tanısında beraber kullanılması bu hastalarda tanının konulması açısından faydalıdır.
Anahtar Kelime:

Konular: Genel ve Dahili Tıp Diş Hekimliği
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA GÖKHAN Ş, Yıldırım Ç, PAMUKÇU GÜNAYDIN G, KURTOĞLU ÇELİK G, KAHRAMAN F, Tanrıverdi F, Ozhasenekler A, EREL O (2018). Thiol/Disulphide Homeostasis Neutrophil Lymphocyte and Platelet Lymphocyte Ratio in Emergency Department Patients with Renal Colic. , 657 - 663. 10.17098/amj.497499
Chicago GÖKHAN Şervan,Yıldırım Çağdaş,PAMUKÇU GÜNAYDIN GÜL,KURTOĞLU ÇELİK Gülhan,KAHRAMAN Fatih Ahmet,Tanrıverdi Fatih,Ozhasenekler Ayhan,EREL Ozcan Thiol/Disulphide Homeostasis Neutrophil Lymphocyte and Platelet Lymphocyte Ratio in Emergency Department Patients with Renal Colic. (2018): 657 - 663. 10.17098/amj.497499
MLA GÖKHAN Şervan,Yıldırım Çağdaş,PAMUKÇU GÜNAYDIN GÜL,KURTOĞLU ÇELİK Gülhan,KAHRAMAN Fatih Ahmet,Tanrıverdi Fatih,Ozhasenekler Ayhan,EREL Ozcan Thiol/Disulphide Homeostasis Neutrophil Lymphocyte and Platelet Lymphocyte Ratio in Emergency Department Patients with Renal Colic. , 2018, ss.657 - 663. 10.17098/amj.497499
AMA GÖKHAN Ş,Yıldırım Ç,PAMUKÇU GÜNAYDIN G,KURTOĞLU ÇELİK G,KAHRAMAN F,Tanrıverdi F,Ozhasenekler A,EREL O Thiol/Disulphide Homeostasis Neutrophil Lymphocyte and Platelet Lymphocyte Ratio in Emergency Department Patients with Renal Colic. . 2018; 657 - 663. 10.17098/amj.497499
Vancouver GÖKHAN Ş,Yıldırım Ç,PAMUKÇU GÜNAYDIN G,KURTOĞLU ÇELİK G,KAHRAMAN F,Tanrıverdi F,Ozhasenekler A,EREL O Thiol/Disulphide Homeostasis Neutrophil Lymphocyte and Platelet Lymphocyte Ratio in Emergency Department Patients with Renal Colic. . 2018; 657 - 663. 10.17098/amj.497499
IEEE GÖKHAN Ş,Yıldırım Ç,PAMUKÇU GÜNAYDIN G,KURTOĞLU ÇELİK G,KAHRAMAN F,Tanrıverdi F,Ozhasenekler A,EREL O "Thiol/Disulphide Homeostasis Neutrophil Lymphocyte and Platelet Lymphocyte Ratio in Emergency Department Patients with Renal Colic." , ss.657 - 663, 2018. 10.17098/amj.497499
ISNAD GÖKHAN, Şervan vd. "Thiol/Disulphide Homeostasis Neutrophil Lymphocyte and Platelet Lymphocyte Ratio in Emergency Department Patients with Renal Colic". (2018), 657-663. https://doi.org/10.17098/amj.497499
APA GÖKHAN Ş, Yıldırım Ç, PAMUKÇU GÜNAYDIN G, KURTOĞLU ÇELİK G, KAHRAMAN F, Tanrıverdi F, Ozhasenekler A, EREL O (2018). Thiol/Disulphide Homeostasis Neutrophil Lymphocyte and Platelet Lymphocyte Ratio in Emergency Department Patients with Renal Colic. Ankara Medical Journal, 18(4), 657 - 663. 10.17098/amj.497499
Chicago GÖKHAN Şervan,Yıldırım Çağdaş,PAMUKÇU GÜNAYDIN GÜL,KURTOĞLU ÇELİK Gülhan,KAHRAMAN Fatih Ahmet,Tanrıverdi Fatih,Ozhasenekler Ayhan,EREL Ozcan Thiol/Disulphide Homeostasis Neutrophil Lymphocyte and Platelet Lymphocyte Ratio in Emergency Department Patients with Renal Colic. Ankara Medical Journal 18, no.4 (2018): 657 - 663. 10.17098/amj.497499
MLA GÖKHAN Şervan,Yıldırım Çağdaş,PAMUKÇU GÜNAYDIN GÜL,KURTOĞLU ÇELİK Gülhan,KAHRAMAN Fatih Ahmet,Tanrıverdi Fatih,Ozhasenekler Ayhan,EREL Ozcan Thiol/Disulphide Homeostasis Neutrophil Lymphocyte and Platelet Lymphocyte Ratio in Emergency Department Patients with Renal Colic. Ankara Medical Journal, vol.18, no.4, 2018, ss.657 - 663. 10.17098/amj.497499
AMA GÖKHAN Ş,Yıldırım Ç,PAMUKÇU GÜNAYDIN G,KURTOĞLU ÇELİK G,KAHRAMAN F,Tanrıverdi F,Ozhasenekler A,EREL O Thiol/Disulphide Homeostasis Neutrophil Lymphocyte and Platelet Lymphocyte Ratio in Emergency Department Patients with Renal Colic. Ankara Medical Journal. 2018; 18(4): 657 - 663. 10.17098/amj.497499
Vancouver GÖKHAN Ş,Yıldırım Ç,PAMUKÇU GÜNAYDIN G,KURTOĞLU ÇELİK G,KAHRAMAN F,Tanrıverdi F,Ozhasenekler A,EREL O Thiol/Disulphide Homeostasis Neutrophil Lymphocyte and Platelet Lymphocyte Ratio in Emergency Department Patients with Renal Colic. Ankara Medical Journal. 2018; 18(4): 657 - 663. 10.17098/amj.497499
IEEE GÖKHAN Ş,Yıldırım Ç,PAMUKÇU GÜNAYDIN G,KURTOĞLU ÇELİK G,KAHRAMAN F,Tanrıverdi F,Ozhasenekler A,EREL O "Thiol/Disulphide Homeostasis Neutrophil Lymphocyte and Platelet Lymphocyte Ratio in Emergency Department Patients with Renal Colic." Ankara Medical Journal, 18, ss.657 - 663, 2018. 10.17098/amj.497499
ISNAD GÖKHAN, Şervan vd. "Thiol/Disulphide Homeostasis Neutrophil Lymphocyte and Platelet Lymphocyte Ratio in Emergency Department Patients with Renal Colic". Ankara Medical Journal 18/4 (2018), 657-663. https://doi.org/10.17098/amj.497499