The Association of IGF‐1 with Clinical Symptoms in Female Patients with Fibromyalgia Syndrome
Yıl: 2018 Cilt: 18 Sayı: 3 Sayfa Aralığı: 410 - 418 Metin Dili: İngilizce DOI: 10.17098/amj.448386 İndeks Tarihi: 26-08-2019
The Association of IGF‐1 with Clinical Symptoms in Female Patients with Fibromyalgia Syndrome
Öz: Introduction: Fibromyalgia syndrome (FMS) is a disease of unknown etiology, which is characterisedby chronic pain. Disturbed growth hormone response, low serum insulin‐like growth factor‐1 (IGF‐1)may play a role in etiopathogenesis of fibromyalgia and may be related to the severity of some symptom.The aim of this study is to investigate serum IGF‐1 levels and relationship of clinical symptoms in femalepatients with fibromyalgia syndrome.Materials and Methods: Thirty‐seven patients with FMS and thirty healthy subjects were included inthis study. All individuals were assessed for clinical findings, widespread pain (Visual Analogue Scale),functional disability and health state (health assesment questionnarie and fibromyalgia impactquestionnarie), anxiety (anxiety State and Trait Anxiety Inventory) and depression (Beck depressioninventory). Likert scale was used for evaluate morning stiffness, level of fatigue, pain, muscle spasm andtenderness.Results: In this study, serum IGF‐1 levels of patients with fibromyalgia were significantly lowercompared to the control group (p=0.004). The IGF‐1 levels were significantly correlated with age (r=‐0.496; p<0.01), muscle spasm (r=‐0.333; p<0.05), tender points (r=‐456; p<0.01) and morning stiffness(r=‐0.463; p<0.01).Conclusion: Low levels of serum IGF‐1 in female patients with fibromyalgia syndrome were associatedwith number of tender points, muscle spasm and stiffness. We have concluded that low levels of serumIGF‐1 might play role in the pathogenesis of fibromyalgia and might be related to severity of symptoms.
Anahtar Kelime: Konular:
Fibromiyalji Sendromlu Kadın Hastalarda IGF‐1'in Klinik Semptomlarla İlişkisi
Öz: Amaç: Fibromiyalji sendromu (FMS), kronik ağrı ile karakterize, etiyolojisi bilinmeyen bir hastalıktır. Bozulmuş büyüme hormonu yanıtı, düşük serum insülin benzeri büyüme faktörü‐1 (IGF‐1) FMS etyopatogenezinde rol oynayabilir ve bazı semptomların şiddeti ile bağlantılı olabilir. Bu çalışmanın amacı fibromiyalji sendromlu kadın hastalarda serum IGF‐1 düzeylerini ve klinik semptomlarla ilişkisini araştırmaktır. Materyal ve Metot: Çalışmaya FMS’lu 37 kadın hasta ve 30 sağlıklı kadın dahil edildi. Tüm bireyler klinik bulgular, ağrı şiddeti (görsel ağrı skalası), fonksiyonel disabilite ve sağlık durumu (sağlık değerlendirme skalası ve fibromiyalji etki skalası), anksiyete (anlık ve sürekli anksiyete ölçeği) ve depresyon (Beck depresyon ölçeği) açısından değerlendirildi. Sabah sertliği, yorgunluk şiddeti, uykusuzluk şiddeti, ağrı şiddeti, kas spazmı şiddeti ve hassasiyet şiddetini değerlendirmek için Likert skalası kulanıldı. Bulgular: Çalışmamızda FMS hastalar kontrol grubuyla kıyaslandığında serum IGF‐1 düzeyleri belirgin olarak daha düşüktü (p=0,004). IGF‐1 düzeyi ile yaş (r=‐0,496; p<0,01), kas spazmı (r=‐0,333; p<0,05), hassas nokta sayısı (r=‐456; p<0,01) ve sabah tutukluğu (r=‐ 0.463; p<0.01) arasında belirgin korelasyon mevcuttu. Sonuç: Fibromiyalji sendromlu kadın hastalarda serum IGF‐1 düzeyi düşüklüğü, hassas nokta sayısı, kas spazmı ve tutukluk ile ilişkiliydi. Çalışmamızda serum IGF‐1 düzeyindeki düşüklüğünün, fibromiyaljinin etyopatogenezinde rol alabileceğini ve semptomların şiddeti ile ilişkili olabileceği sonucuna vardık.
Anahtar Kelime: Konular:
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | GÜMÜŞ ATALAY S (2018). The Association of IGF‐1 with Clinical Symptoms in Female Patients with Fibromyalgia Syndrome. , 410 - 418. 10.17098/amj.448386 |
| Chicago | GÜMÜŞ ATALAY Sevgi The Association of IGF‐1 with Clinical Symptoms in Female Patients with Fibromyalgia Syndrome. (2018): 410 - 418. 10.17098/amj.448386 |
| MLA | GÜMÜŞ ATALAY Sevgi The Association of IGF‐1 with Clinical Symptoms in Female Patients with Fibromyalgia Syndrome. , 2018, ss.410 - 418. 10.17098/amj.448386 |
| AMA | GÜMÜŞ ATALAY S The Association of IGF‐1 with Clinical Symptoms in Female Patients with Fibromyalgia Syndrome. . 2018; 410 - 418. 10.17098/amj.448386 |
| Vancouver | GÜMÜŞ ATALAY S The Association of IGF‐1 with Clinical Symptoms in Female Patients with Fibromyalgia Syndrome. . 2018; 410 - 418. 10.17098/amj.448386 |
| IEEE | GÜMÜŞ ATALAY S "The Association of IGF‐1 with Clinical Symptoms in Female Patients with Fibromyalgia Syndrome." , ss.410 - 418, 2018. 10.17098/amj.448386 |
| ISNAD | GÜMÜŞ ATALAY, Sevgi. "The Association of IGF‐1 with Clinical Symptoms in Female Patients with Fibromyalgia Syndrome". (2018), 410-418. https://doi.org/10.17098/amj.448386 |
| APA | GÜMÜŞ ATALAY S (2018). The Association of IGF‐1 with Clinical Symptoms in Female Patients with Fibromyalgia Syndrome. Ankara Medical Journal, 18(3), 410 - 418. 10.17098/amj.448386 |
| Chicago | GÜMÜŞ ATALAY Sevgi The Association of IGF‐1 with Clinical Symptoms in Female Patients with Fibromyalgia Syndrome. Ankara Medical Journal 18, no.3 (2018): 410 - 418. 10.17098/amj.448386 |
| MLA | GÜMÜŞ ATALAY Sevgi The Association of IGF‐1 with Clinical Symptoms in Female Patients with Fibromyalgia Syndrome. Ankara Medical Journal, vol.18, no.3, 2018, ss.410 - 418. 10.17098/amj.448386 |
| AMA | GÜMÜŞ ATALAY S The Association of IGF‐1 with Clinical Symptoms in Female Patients with Fibromyalgia Syndrome. Ankara Medical Journal. 2018; 18(3): 410 - 418. 10.17098/amj.448386 |
| Vancouver | GÜMÜŞ ATALAY S The Association of IGF‐1 with Clinical Symptoms in Female Patients with Fibromyalgia Syndrome. Ankara Medical Journal. 2018; 18(3): 410 - 418. 10.17098/amj.448386 |
| IEEE | GÜMÜŞ ATALAY S "The Association of IGF‐1 with Clinical Symptoms in Female Patients with Fibromyalgia Syndrome." Ankara Medical Journal, 18, ss.410 - 418, 2018. 10.17098/amj.448386 |
| ISNAD | GÜMÜŞ ATALAY, Sevgi. "The Association of IGF‐1 with Clinical Symptoms in Female Patients with Fibromyalgia Syndrome". Ankara Medical Journal 18/3 (2018), 410-418. https://doi.org/10.17098/amj.448386 |
