Yıl: 2019 Cilt: 8 Sayı: 1 Sayfa Aralığı: 32 - 36 Metin Dili: İngilizce DOI: 10.5455/medscience.2018.07.8905 İndeks Tarihi: 26-09-2019

The effect of measurement uncertainty for HOMA-IR in assessment of insulin resistance

Öz:
In this study, it is aimed to estimate not just the uncertainty measurement for the parameters of glucose and insulin having role when calculating HOMA-IR, but also true positiveness and negativeness in terms of cut-off values. The evaluation of the acceptability of the uncertainty value was also among the goals of the study. The uncertainty measurement for glucose and insulin is calculated as uncertainty measurement of HOMA-IR based on Eurochem/CITAC Guide CG 4. The uncertainty measurement for glucose and insulin was estimated as 3.83% and 4.16%, respectively. The measurement uncertainty for the calculated test HOMA-IR was calculated with cut-off values as 27% (0.27). Based on the cut-off value for HOMA-IR of 2.5%, IR(+) and IR(-) patients were 155 and 265, respectively. If the uncertainty measurement for HOMA-IR was added to its calculation, the cut-off value was detected as 2.23-2.77%. We reported the measurement uncertainty of the calculated test HOMA-IR at 95 % CI as 0.27 between 2.23 - 2.77. Especially for the tests used for screening; determination of cut-off values as a range including measurement uncertainty instead of a single value will be more suitable. No data is found in the literature for the calculated test HOMA-IR up to date.
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  • Tang Q, Li X, Song P,et al. Optimal cut-off values for the homeostasis model assessment of insulin resistance (HOMA-IR) and pre-diabetes screening: Developments in research and prospects for the future. Drug Discov Ther. 2015;9:380-5.
  • Magri CJ, Fava S, Galea J. Prediction of insulin resistance in type 2 diabetes mellitus using routinely available clinical parameters. Diabetes Metab Syndr. 2016;10 Suppl 1):96-101.
  • Reaven GM. Pathophysiology of insulin resistance in human disease. Physiol Rev. 1995;75:473-86.
  • Eckel RH, Grundy SM, Zimmet PZ. The metabolic syndrome. Lancet (London, England). 2005;365:1415-28
  • Lillioja S, Mott DM, Howard BV, et al. Impaired glucose tolerance as a disorder of insulin action. Longitudinal and cross-sectional studies in Pima Indians. N Engl J Med. 1988;318:1217-25.
  • Katz A, Nambi SS, Mather K, et al. Quantitative insulin sensitivity check index: a simple, accurate method for assessing insulin sensitivity in humans. J Clin Endocrinol Metab. 2000;85:2402-10.
  • Aregbesola A, Virtanen JK, Voutilainen S, et al. Serum ferritin and glucose homeostasis: change in the association by glycemic state. Diabetes Metab Res Rev. 2015;31:507-14.
  • Matthews DR, Hosker JP, Rudenski AS,et al. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia. 1985;28:412-9.
  • Ellison S, Williams A. EURACHEM/CITAC Guide CG 4: Quantifying uncertainty in analytical measurement. 2012. pp. 4–6.
  • Matar G, Poggi B, Meley R, et al. Uncertainty in measurement for 43 biochemistry, immunoassay, and hemostasis routine analytes evaluated by a method using only external quality assessment data. Clin Chem Lab Med. 2015;53:1725-36.
  • Kin Tekce B, Tekce H, Aktas G, et al. The role of the uncertainty of measurement of serum creatinine concentrations in the diagnosis of acute kidney injury. Ren Fail. 2016;38:305-10.
  • Beck SC, Lock RJ. Uncertainty of measurement: an immunology laboratory perspective. Ann Clin Biochem. 2015;52(Pt 1):7-17.
  • Theodorsson E. Uncertainty in measurement and total error: tools for coping with diagnostic uncertainty. Clin Lab Med. 2017;37:15-34.
  • White GH, Farrance I, AACB Uncertainty of Measurement Working Group. Uncertainty of measurement in quantitative medical testing: a laboratory implementation guide. Clin Biochem Rev. 2004;25:1–24
  • Moses G, Crawford L. Traceability and measurement of uncertainty for medical laboratories. QMP-LS.OLA.2011. Canada (http://www.qmpls.org).
  • Farrance I, Frenkel R. Uncertainty of Measurement: A Review of the Rules for Calculating Uncertainty Components through Functional Relationships. Clin Biochem Rev. 2012;33:49-75.
  • Plebani M. Errors in clinical laboratories or errors in laboratory medicine? Clin Chem Lab Med. 2006;44:750–9
  • European Co-operation for Accreditation of Laboratories, EAL-G23, Edition 1, August. 1996
  • 1Feinberg M, Boulanger B, Dewe W, et al. New advances in method validation and measurement uncertainty aimed at improving the quality of chemical data. Anal Bioanal Chem. 2004;380:502-14.
  • Adams TM. A2LA Guide for the Estimation of Measurement Uncertainty In Testing July 2002.
  • ISO 15189:2014.Medical laboratories requirements for quality and competence. 2nd ed. International organization for standards, Geneva,Switzerland, 2014
  • Kuwa K. Internal Quality Control and External Quality Assessment on POCT. Rinsho Byori. 2015;63:224-31
  • Ricos C, Alvarez V, Cava F, et al. Current databases on biologic variation: pros, cons and progress. Scand J Clin Lab Invest. 1999;59:491-500.
  • Fraser CG. Biological variation: from principle to practicies. 140 AACC Press,Washington. 2001
  • Öztürk O, Serdar M, Öztürk M, et al. Calculation of uncertainty for glucose: may it affect the diagnosis of gestational diabetes? Turk J Biochem. 2012;37;68–72
  • Chen H, Zhang L, Bi X, et al. Two evaluation budgets for the measurement uncertainty of glucose in clinical chemistry. Korean J Lab Med. 2011;31:167-171.
APA ERCAN KARADAĞ M, Caniklioğlu A, FIRAT OĞUZ E, yücel ç, Özcan M, Yılmaz F, ABUŞOĞLU S, Topcuoglu C, BAYRAKÇEKEN Y (2019). The effect of measurement uncertainty for HOMA-IR in assessment of insulin resistance. , 32 - 36. 10.5455/medscience.2018.07.8905
Chicago ERCAN KARADAĞ MÜJGAN,Caniklioğlu Ayşen,FIRAT OĞUZ Esra,yücel çiğdem,Özcan Mehmet,Yılmaz Fatma Meriç,ABUŞOĞLU Sedat,Topcuoglu Canan,BAYRAKÇEKEN Yusuf The effect of measurement uncertainty for HOMA-IR in assessment of insulin resistance. (2019): 32 - 36. 10.5455/medscience.2018.07.8905
MLA ERCAN KARADAĞ MÜJGAN,Caniklioğlu Ayşen,FIRAT OĞUZ Esra,yücel çiğdem,Özcan Mehmet,Yılmaz Fatma Meriç,ABUŞOĞLU Sedat,Topcuoglu Canan,BAYRAKÇEKEN Yusuf The effect of measurement uncertainty for HOMA-IR in assessment of insulin resistance. , 2019, ss.32 - 36. 10.5455/medscience.2018.07.8905
AMA ERCAN KARADAĞ M,Caniklioğlu A,FIRAT OĞUZ E,yücel ç,Özcan M,Yılmaz F,ABUŞOĞLU S,Topcuoglu C,BAYRAKÇEKEN Y The effect of measurement uncertainty for HOMA-IR in assessment of insulin resistance. . 2019; 32 - 36. 10.5455/medscience.2018.07.8905
Vancouver ERCAN KARADAĞ M,Caniklioğlu A,FIRAT OĞUZ E,yücel ç,Özcan M,Yılmaz F,ABUŞOĞLU S,Topcuoglu C,BAYRAKÇEKEN Y The effect of measurement uncertainty for HOMA-IR in assessment of insulin resistance. . 2019; 32 - 36. 10.5455/medscience.2018.07.8905
IEEE ERCAN KARADAĞ M,Caniklioğlu A,FIRAT OĞUZ E,yücel ç,Özcan M,Yılmaz F,ABUŞOĞLU S,Topcuoglu C,BAYRAKÇEKEN Y "The effect of measurement uncertainty for HOMA-IR in assessment of insulin resistance." , ss.32 - 36, 2019. 10.5455/medscience.2018.07.8905
ISNAD ERCAN KARADAĞ, MÜJGAN vd. "The effect of measurement uncertainty for HOMA-IR in assessment of insulin resistance". (2019), 32-36. https://doi.org/10.5455/medscience.2018.07.8905
APA ERCAN KARADAĞ M, Caniklioğlu A, FIRAT OĞUZ E, yücel ç, Özcan M, Yılmaz F, ABUŞOĞLU S, Topcuoglu C, BAYRAKÇEKEN Y (2019). The effect of measurement uncertainty for HOMA-IR in assessment of insulin resistance. Medicine Science, 8(1), 32 - 36. 10.5455/medscience.2018.07.8905
Chicago ERCAN KARADAĞ MÜJGAN,Caniklioğlu Ayşen,FIRAT OĞUZ Esra,yücel çiğdem,Özcan Mehmet,Yılmaz Fatma Meriç,ABUŞOĞLU Sedat,Topcuoglu Canan,BAYRAKÇEKEN Yusuf The effect of measurement uncertainty for HOMA-IR in assessment of insulin resistance. Medicine Science 8, no.1 (2019): 32 - 36. 10.5455/medscience.2018.07.8905
MLA ERCAN KARADAĞ MÜJGAN,Caniklioğlu Ayşen,FIRAT OĞUZ Esra,yücel çiğdem,Özcan Mehmet,Yılmaz Fatma Meriç,ABUŞOĞLU Sedat,Topcuoglu Canan,BAYRAKÇEKEN Yusuf The effect of measurement uncertainty for HOMA-IR in assessment of insulin resistance. Medicine Science, vol.8, no.1, 2019, ss.32 - 36. 10.5455/medscience.2018.07.8905
AMA ERCAN KARADAĞ M,Caniklioğlu A,FIRAT OĞUZ E,yücel ç,Özcan M,Yılmaz F,ABUŞOĞLU S,Topcuoglu C,BAYRAKÇEKEN Y The effect of measurement uncertainty for HOMA-IR in assessment of insulin resistance. Medicine Science. 2019; 8(1): 32 - 36. 10.5455/medscience.2018.07.8905
Vancouver ERCAN KARADAĞ M,Caniklioğlu A,FIRAT OĞUZ E,yücel ç,Özcan M,Yılmaz F,ABUŞOĞLU S,Topcuoglu C,BAYRAKÇEKEN Y The effect of measurement uncertainty for HOMA-IR in assessment of insulin resistance. Medicine Science. 2019; 8(1): 32 - 36. 10.5455/medscience.2018.07.8905
IEEE ERCAN KARADAĞ M,Caniklioğlu A,FIRAT OĞUZ E,yücel ç,Özcan M,Yılmaz F,ABUŞOĞLU S,Topcuoglu C,BAYRAKÇEKEN Y "The effect of measurement uncertainty for HOMA-IR in assessment of insulin resistance." Medicine Science, 8, ss.32 - 36, 2019. 10.5455/medscience.2018.07.8905
ISNAD ERCAN KARADAĞ, MÜJGAN vd. "The effect of measurement uncertainty for HOMA-IR in assessment of insulin resistance". Medicine Science 8/1 (2019), 32-36. https://doi.org/10.5455/medscience.2018.07.8905