Yıl: 2018 Cilt: 7 Sayı: 2 Sayfa Aralığı: 306 - 311 Metin Dili: İngilizce DOI: 10.5455/medscience.2017.06.8695 İndeks Tarihi: 30-09-2019

The effect of gender on reversal of non-depolarizing block with Sugammadex

Öz:
Sugammadex is a rapid and selective aminosteroid agent that has entered use recently. We aimed to research the effect of gender on reversal of non-depolarizing block with sugammadex. We designed a prospective study. The research included a total of 100 cases who underwent rhinoplasty operation administered general anaesthesia. Cases were divided according to gender as male (Group M) and female (Group F). At the end of the operation for patients with TOF value 25%, patients were given 2 mg kg-1 iv sugammadex. Duration from the rocuronium administration until the TOF value was zero(TOF0), the time from sugammadex administration until TOF reached from 25% to 90% was recorded (TOF25-90). The time from TOF90 to extubation was named the extubation duration. From the time the patients entered the PCU until Aldrete score was ≥9 was named the recovery duration and recorded. The time for the groups to TOF25-90 was 123.84 ± 38.03 s in Group M and 122.06 ± 30.461 s in Group F (p > 0.05). The extubation duration was 189.68 ± 41.37 s in Group M and 206.50 ± 45.99 in Group F (p = 0.316). The recovery time was 8.26 ± 14 min in Group M and 8.48 ± 14.23 min in Group F (p = 0.328). After the administration of sugammadex, there was no difference observed between the groups in terms of the TOF25-90 duration, recovery and extubation duration. As a result, conclusion was reached that gender did not affect rocuronium reversal with sugammadex
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  • Miller RD, Staendaert FG. Neuromuscular physiology and pharmacology. Anesthesia 6th Edition Philadelphia, Elsevier, Churchill, Livingstone, 2010:523-25.
  • Diefenbach C. Neuromuscular monitorization during the anesthesia and surgery. 2th Edition. Turgut Pub. İstanbul 1999: 118-22.
  • Esener Z. Clinical anaesthesia. 3th Edition, Logos Pub. Istanbul, 1997:135-60.
  • Kim KS, Lew SH, Cho HY, et al. Residual paralysis induced by either vecuronium or rocuronium after reversal with pyridostigmine. Anesth Analg. 2002;95(6):1656-60.
  • Sacan O, White PF, Tufanogullari B, et al. Sugammadex reversal of rocuronium-induced neuromuscular blockade: a comparison with neostigmine-glycopyrrolate and edrophonium-atropine. Anesth Analg. 2007;104(3):569-74.
  • Pleym H, Spigset O, Kharasch ED, et al. Gender differences in drug effects: implications for anesthesiologists. Acta Anaesthesiol Scand. 2003;47(3):241-59.
  • Mencke T, Soltész S, Grundmann U, Bet al. Time course of neuromuscular blockade after rocuronium. A comparison between women and men. Anaesthesist. 2000;49(7):609-12.
  • Hoymork SC, Raeder J. Why do women wake up faster than men from propofol anaesthesia. Br J Anaesth. 2005;95(5):627-33.
  • Beierle I, Meibohm B, Derendorf H. Gender differences in pharmacokinetics and pharmacodynamics. Int J Clin Pharmacol Ther. 1999;37(11): 529-47.
  • Kashuba AD, Bertino JS Jr, Kearns GL, et al. Quantitation of three-month intraindividual variability and influence of sex andmenstrual cycle phase on CYP1A2, N-acetyltransferase-2, and xanthine oxidaseactivity determined with caffeine phenotyping. Clin Pharmacol Ther. 1998; 63(5):540-51.
  • Meibohm B, Beierle I, Derendorf H. How important are gender differences in pharmacokinetics? Clin Pharmacokinet. 2002;41(5):329-42.
  • Gourlay GK, Kowalski SR, Plummer JL, et al. Fentanyl blood concentrationanalgesic response relationship in the treatment of postoperative pain. Anesth Analg. 1988;67(4):329–37.
  • Buchanan FF, Myles PS, Cicuttini F. Effect of patient sex on general anaesthesia and recovery. Br J Anaesth. 2011;106(6):832-9.
  • Whitley H, Lindsey W. Sex-based differences in drug activity. Am Fam Physician. 2009; 80(11):1254-8.
  • Xue FS, Tong SY, Liao X, et al. Dose-Response and Time Course of Effect of Rocuronium in Male and Female Anesthetized Patients Anesth Analg. 1997;85(3):667-71.
  • Claudius C, Garvey LH, Viby-Mogensen J. The undesirable effects of neuromuscular bloking drugs. Anaesthesia. 2009;64:10-21.
  • Adamus M, Koutna J, Gabrhelik T, et al. Influence of gender on the onset and duration of rocuronium-induced neuromuscular block. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub. 2007;151(2):301-5.
  • Apfelbaum JL, Grasela TH, Hug CC Jr, et al. The initial clinical experience of 1819 physicians in maintaining anesthesia with propofol: characteristics associated with prolonged time to awakening. Anesth Analg. 1993;77(4):104.
  • Gear RW, Miaskowski C, Gordon NC, et al. Kappa-opioids produce significantly greater analgesia in women than in men. Nat Med. 1996;2(1):1248–50.
  • Naguib M, Kopman AF, Ensor JE. Neuromuscular monitoring and postoperative residual curarisation: a meta-analysis. Br J Anaesth. 2007;98(3):302-16.
  • Baillard C, Reboul-Marty J, Larmignat P, et al. Residual curarization in the recovery room after vecuronium. Br J Anaesth. 2000;84(3):394-5.
  • Debaene B, Meistelman C. Indications and clinical use of sugammadex. Ann Fr Anesth Reanim. 2009;28(2):57-63.
  • Mirakhur RK, Sugammadex in clinical practice, Anaesthesia, 2009;64:45-54.
  • Bom A, Bradley M, Cameron K, et al. A novel concept of reversing neuromuscular block: chemical encapsulation of rocuronium bromide by a cyclodextrin- based synthetic host. Angew Chem Int Ed. 2002;41(2):266-70.
  • Khuenl-Brady KS, Wattwil M, Vanacker BF, et al. Sugammadex provides faster reversal of vecuronium-induced neuromuscular blockade compared with neostigmine: a multicenter, randomized, controlled trial. Anesth Analg. 2010; 110(1):64-73.
  • Piskin O, Kucukosman G, Altun DU, et al.The effect of sugammadex on postoperative cognitive function and recovery. Rev Bras Anestesiol. 2016; 66(4):376-82.
  • Leykin Y, Pellis P, Lucca. M, et al. The Pharmacodynamic Effects of rocuronium when dosed according to real body weight or ideal body weight in morbidly obese patients. Anesth Analg. 2004;99(4):1086 -9.
  • Sanfilippo M, Alessandri F, Wefki Abdelgawwad Shousha AA, et al. Sugammadex and ideal body weight in bariatric surgery. Anesthesiol Res Pract. 2013;2013:389782. 311
APA Öztürk A, PİŞKİN Ö, Küçükosman G, KÖKSAL B, OKYAY R, Ayoglu H (2018). The effect of gender on reversal of non-depolarizing block with Sugammadex. , 306 - 311. 10.5455/medscience.2017.06.8695
Chicago Öztürk Alper,PİŞKİN Özcan,Küçükosman Gamze,KÖKSAL Bengü Gülhan,OKYAY Rahşan Dilek,Ayoglu Hilal The effect of gender on reversal of non-depolarizing block with Sugammadex. (2018): 306 - 311. 10.5455/medscience.2017.06.8695
MLA Öztürk Alper,PİŞKİN Özcan,Küçükosman Gamze,KÖKSAL Bengü Gülhan,OKYAY Rahşan Dilek,Ayoglu Hilal The effect of gender on reversal of non-depolarizing block with Sugammadex. , 2018, ss.306 - 311. 10.5455/medscience.2017.06.8695
AMA Öztürk A,PİŞKİN Ö,Küçükosman G,KÖKSAL B,OKYAY R,Ayoglu H The effect of gender on reversal of non-depolarizing block with Sugammadex. . 2018; 306 - 311. 10.5455/medscience.2017.06.8695
Vancouver Öztürk A,PİŞKİN Ö,Küçükosman G,KÖKSAL B,OKYAY R,Ayoglu H The effect of gender on reversal of non-depolarizing block with Sugammadex. . 2018; 306 - 311. 10.5455/medscience.2017.06.8695
IEEE Öztürk A,PİŞKİN Ö,Küçükosman G,KÖKSAL B,OKYAY R,Ayoglu H "The effect of gender on reversal of non-depolarizing block with Sugammadex." , ss.306 - 311, 2018. 10.5455/medscience.2017.06.8695
ISNAD Öztürk, Alper vd. "The effect of gender on reversal of non-depolarizing block with Sugammadex". (2018), 306-311. https://doi.org/10.5455/medscience.2017.06.8695
APA Öztürk A, PİŞKİN Ö, Küçükosman G, KÖKSAL B, OKYAY R, Ayoglu H (2018). The effect of gender on reversal of non-depolarizing block with Sugammadex. Medicine Science, 7(2), 306 - 311. 10.5455/medscience.2017.06.8695
Chicago Öztürk Alper,PİŞKİN Özcan,Küçükosman Gamze,KÖKSAL Bengü Gülhan,OKYAY Rahşan Dilek,Ayoglu Hilal The effect of gender on reversal of non-depolarizing block with Sugammadex. Medicine Science 7, no.2 (2018): 306 - 311. 10.5455/medscience.2017.06.8695
MLA Öztürk Alper,PİŞKİN Özcan,Küçükosman Gamze,KÖKSAL Bengü Gülhan,OKYAY Rahşan Dilek,Ayoglu Hilal The effect of gender on reversal of non-depolarizing block with Sugammadex. Medicine Science, vol.7, no.2, 2018, ss.306 - 311. 10.5455/medscience.2017.06.8695
AMA Öztürk A,PİŞKİN Ö,Küçükosman G,KÖKSAL B,OKYAY R,Ayoglu H The effect of gender on reversal of non-depolarizing block with Sugammadex. Medicine Science. 2018; 7(2): 306 - 311. 10.5455/medscience.2017.06.8695
Vancouver Öztürk A,PİŞKİN Ö,Küçükosman G,KÖKSAL B,OKYAY R,Ayoglu H The effect of gender on reversal of non-depolarizing block with Sugammadex. Medicine Science. 2018; 7(2): 306 - 311. 10.5455/medscience.2017.06.8695
IEEE Öztürk A,PİŞKİN Ö,Küçükosman G,KÖKSAL B,OKYAY R,Ayoglu H "The effect of gender on reversal of non-depolarizing block with Sugammadex." Medicine Science, 7, ss.306 - 311, 2018. 10.5455/medscience.2017.06.8695
ISNAD Öztürk, Alper vd. "The effect of gender on reversal of non-depolarizing block with Sugammadex". Medicine Science 7/2 (2018), 306-311. https://doi.org/10.5455/medscience.2017.06.8695