Meta-analysis of the relationship between MnSOD polymorphism and cancer in the Turkish and Cypriot population

Tuğçe BALCI, (Vocational School of Health Services, Medical Biology Department, Near East University, Nicosia, Kuzey Kıbrıs Türk Cumhuriyeti)
CUMHUR GÜNDÜZ (Ege University, Faculty of Medicine, Department of Medical Biology, Bornova, Izmir, Turkey)
Türk Biyokimya Dergisi
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Yıl: 2018 Cilt: 43 Sayı: 2 Sayfa Aralığı: 184 - 196 Metin Dili: İngilizce DOI: 10.1515/tjb-2017-0161 İndeks Tarihi: 04-10-2019

Meta-analysis of the relationship between MnSOD polymorphism and cancer in the Turkish and Cypriot population

Öz:
Objectives: The association between manganese superoxidedismutase (MnSOD) p.Val16Ala polymorphism andcancer has been shown in various studies. The aim of thisstudy is to investigate the relationship between MnSODpolymorphism (V/V, V/A, A/A) and cancer in the Turkishand Cypriot population through meta-analysis.Material and methods: The present study included metaanalysisof 14 publications covering 2413 cancer patientsand 2907 healthy control groups from 2005 to 2016. Pooledodds ratio (OR) and 95% confidence interval (CI) were calculatedusing the random effect model of DerSimonianand Laird for each study. Publication bias was checkedwith funnel plot by Begg’s and Egger’s test statistics.Results: Meta-analysis of MnSOD polymorphism was performedin the additive model (AV vs. VV; OR = 1.133, 95%CI: 1.002–1.282), allele contrast (A vs. V; OR = 1.016, 95%CI: 0.930–1.278), homozygote model (AA vs. VV; OR = 0.983,95% CI: 0.839–1.153), dominant model (AA + AV vs. VV;OR = 1.090, 95% CI: 0.971–1.223) and recessive model (AA vs.AV + VV; OR = 0.924, 95% CI: 0.803–1.064). The A/V genotypepolymorphism was found be significant for cancer.Conclusion: The frequency of the A/V heterozygote genotypeof the MnSOD polymorphisms is found to be higherin the Cypriot and Turkish populations than any othergenotype.
Anahtar Kelime:

Konular: Diş Hekimliği Toksikoloji Biyokimya ve Moleküler Biyoloji Farmakoloji ve Eczacılık

MnSOD polimorfizmi ile kanser arasındaki ilişkinin Türk ve Kıbrıs toplumundaki meta analizi

Öz:
Amaç: Çalışmalarda mangan süperoksit dismutaz (MnSOD) p.Val16Ala polimorfizmi ile kanser arasındaki ilişki gösterilmiştir. Bu çalışmanın amacı, meta-analizle Türk ve Kıbrıs toplumundaki MnSOD polimorfizmi (V/V, V/A, A/A) ve kanser arasındaki ilişkiyi araştırmaktır. Gereç ve Yöntem: Bu çalışma, 2005-2016 yılları arasındaki 2413 kanser hastasını ve 2907 sağlıklı kontrol grubunu kapsayan 14 araştırmanın meta-analizini içermektedir. Her bir çalışma için odds oranı (OR) ve % 95 güven aralığı (CI) değerleri Dersimonian ve Laird’nin tesadüfi etki modeli kullanılarak belirlendi. Yayın yanlılığı, Begg ve Egger’ in test istatistiklerine göre funnel plot ile kontrol edildi. Bulgular: MnSOD polimorfizminin meta analizi, additif model (AV vs. VV: OR = 1,133, % 95 CI: 1,002–1,282), alel kontrast (A vs. V; OR = 1,016, % 95 CI: 0,930–1,278), homozigot model (AA vs. VV; OR = 0,983, % 95 CI: 0,839–1,153) dominant model (AA + AV vs. VV; OR = 1,090, % 95 CI: 0,971–1,223)ve resesif model (AA vs. AV + VV; OR = 0,924, % 95 CI: 0,803–1,064) olarak yapıldı. A/V genotip polimorfizmi kanser için önemli olduğu bulundu. Sonuç: MnSOD polimorfizminin A/V heterozigot genotip sıklığı, Kıbrıs ve Türk popülasyonlarında diğer genotiplerden daha yüksek bulunmuştur.
Anahtar Kelime:

Konular: Diş Hekimliği Toksikoloji Biyokimya ve Moleküler Biyoloji Farmakoloji ve Eczacılık
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA BALCI T, Gunduz C (2018). Meta-analysis of the relationship between MnSOD polymorphism and cancer in the Turkish and Cypriot population. , 184 - 196. 10.1515/tjb-2017-0161
Chicago BALCI Tuğçe,Gunduz Cumhur Meta-analysis of the relationship between MnSOD polymorphism and cancer in the Turkish and Cypriot population. (2018): 184 - 196. 10.1515/tjb-2017-0161
MLA BALCI Tuğçe,Gunduz Cumhur Meta-analysis of the relationship between MnSOD polymorphism and cancer in the Turkish and Cypriot population. , 2018, ss.184 - 196. 10.1515/tjb-2017-0161
AMA BALCI T,Gunduz C Meta-analysis of the relationship between MnSOD polymorphism and cancer in the Turkish and Cypriot population. . 2018; 184 - 196. 10.1515/tjb-2017-0161
Vancouver BALCI T,Gunduz C Meta-analysis of the relationship between MnSOD polymorphism and cancer in the Turkish and Cypriot population. . 2018; 184 - 196. 10.1515/tjb-2017-0161
IEEE BALCI T,Gunduz C "Meta-analysis of the relationship between MnSOD polymorphism and cancer in the Turkish and Cypriot population." , ss.184 - 196, 2018. 10.1515/tjb-2017-0161
ISNAD BALCI, Tuğçe - Gunduz, Cumhur. "Meta-analysis of the relationship between MnSOD polymorphism and cancer in the Turkish and Cypriot population". (2018), 184-196. https://doi.org/10.1515/tjb-2017-0161
APA BALCI T, Gunduz C (2018). Meta-analysis of the relationship between MnSOD polymorphism and cancer in the Turkish and Cypriot population. Türk Biyokimya Dergisi, 43(2), 184 - 196. 10.1515/tjb-2017-0161
Chicago BALCI Tuğçe,Gunduz Cumhur Meta-analysis of the relationship between MnSOD polymorphism and cancer in the Turkish and Cypriot population. Türk Biyokimya Dergisi 43, no.2 (2018): 184 - 196. 10.1515/tjb-2017-0161
MLA BALCI Tuğçe,Gunduz Cumhur Meta-analysis of the relationship between MnSOD polymorphism and cancer in the Turkish and Cypriot population. Türk Biyokimya Dergisi, vol.43, no.2, 2018, ss.184 - 196. 10.1515/tjb-2017-0161
AMA BALCI T,Gunduz C Meta-analysis of the relationship between MnSOD polymorphism and cancer in the Turkish and Cypriot population. Türk Biyokimya Dergisi. 2018; 43(2): 184 - 196. 10.1515/tjb-2017-0161
Vancouver BALCI T,Gunduz C Meta-analysis of the relationship between MnSOD polymorphism and cancer in the Turkish and Cypriot population. Türk Biyokimya Dergisi. 2018; 43(2): 184 - 196. 10.1515/tjb-2017-0161
IEEE BALCI T,Gunduz C "Meta-analysis of the relationship between MnSOD polymorphism and cancer in the Turkish and Cypriot population." Türk Biyokimya Dergisi, 43, ss.184 - 196, 2018. 10.1515/tjb-2017-0161
ISNAD BALCI, Tuğçe - Gunduz, Cumhur. "Meta-analysis of the relationship between MnSOD polymorphism and cancer in the Turkish and Cypriot population". Türk Biyokimya Dergisi 43/2 (2018), 184-196. https://doi.org/10.1515/tjb-2017-0161
Sayfa Oluşturulma Tarihi
17-04-2024 12:13

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