The effects of royal jelly on the oxidantantioxidant system in rats with N-methyl- N-nitrosourea-induced breast cancer
Yıl: 2018 Cilt: 43 Sayı: 2 Sayfa Aralığı: 176 - 183 Metin Dili: İngilizce DOI: 10.1515/tjb-2017-0140 İndeks Tarihi: 04-10-2019
The effects of royal jelly on the oxidantantioxidant system in rats with N-methyl- N-nitrosourea-induced breast cancer
Öz: Objectives: To determine the effect of royal jelly (RJ) onthe oxidant-antioxidant balance in rats with N-methyl-Nnitrosourea(MNU) induced breast cancer and to comparethis with the chemotherapeutic agent paclitaxel.Material and methods: Fifty-six female Sprague Dawley ratswere divided into five groups. Except control group (n = 8,Group I) others received MNU (50 mg/kg, a single dose, i.p.)to develop breast cancer: Group II (n = 8) untreated, GroupIII (n = 7) treated with paclitaxel (15 mg/kg/week, 3 times,i.p.), Group IV (n = 7) with RJ (by oral gavage, 100 mg/kg/day, for 30 days), and Group V (n = 7), with paclitaxel + RJ.At the end of 30 days, histopathological and biochemicalparameters were evaluated in breast tissues.Results: Levels of protein carbonyl (PC) and 8-hydroxydeoxyguanosine(8-OHdG) were higher in Group V than inGroup II while malondialdehyde (MDA) levels were lowerin groups IV and V compared to Group II (p < 0.05). Levelsof catalase (CAT) in Group V and glutathione (GSH) inGroup III were higher than Group II (p < 0.05). Glutathioneperoxidase (GPx) and superoxide dismutase (SOD) levelsdid not significantly different. Decreasing effect of RJ onCA15-3 levels was relevant to histopathological results.Conclusion: Although RJ (with or without paclitaxel) hadincreasing effect of antioxidant status it was insufficientto reduce oxidative stress in breast cancer.
Anahtar Kelime: Konular:
N-metil N-Nitrosoüre ile meme kanseri oluşturulmuş sıçanlarda arı sütünün oksidan –antioksidan sistem üzerine etkileri
Öz: Amaç: N-metil-N-nitrosourea (MNU) ile indüklenen meme kanserli sıçanlarda, arı sütünün oksidan-antioksidan denge üzerindeki etkisini belirlemek ve bunu kemoterapötik ajan olan paklitaksel ile karşılaştırmak. Gereç ve Yöntem: Elli altı dişi Sprague Dawley sıçan, beş gruba bölündü. Kontrol grubu Grup I (n = 8) hariç diğer dört grup MNU (50 mg/kg, tek, doz ip) ile meme kanseri oluşturuldu. Grup II (n = 8), tedavi edilmemiş, Grup III (n = 7), paklitaksel (15 mg/kg/hafta, 3 kez, ip) ile; Grup IV (n = 7) arı sütü (oral gavaj ile, 100 mg/kg/gün, 30 gün) ile ve Grup V (n = 7), paklitaksel ve arı sütü ile tedavi olmak üzere beş gruba ayrıldı. günün sonunda, meme dokularında histopatolojik inceleme ve biyokimyasal parametreler değerlendirildi. Bulgular: Protein karbonil (PC) ve 8-hidroksi deoksiguanozinin (8-OHdG) düzeyleri Grup V‘de Grup II‘ye göre yüksek, malondialdehit (MDA) düzeyleri grup IV ve V’de Grup II‘ye göre daha düşüktü (p < 0.05). Grup V‘de katalaz (CAT) ve Grup III’de glutatyon (GSH) seviyeleri Grup II’den daha yüksekti (p < 0.05). Glutatyon peroksidaz (GPx) ve süperoksit dismutaz (SOD) düzeyleri arasında anlamlı farklılık yoktu. Arı sütünün CA15-3 düzeyleri üzerine azaltıcı etkisi, histopatolojik sonuçlar ile uyumlu idi. Sonuç: Meme kanserinde arı sütü (paklitaksel ile veya paklitakselsiz) antioksidan durumu arttırıcı yönde etki göstermesine rağmen oksidatif stresi azaltmada yetersizdi.
Anahtar Kelime: Konular:
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | Malkoç M, us altay d, Alver A, ERSÖZ Ş, ŞEN T, VANİZOR KURAL B, UYDU H (2018). The effects of royal jelly on the oxidantantioxidant system in rats with N-methyl- N-nitrosourea-induced breast cancer. , 176 - 183. 10.1515/tjb-2017-0140 |
| Chicago | Malkoç Meltem,us altay diler,Alver Ahmet,ERSÖZ Şafak,ŞEN Tuğba Mazlum,VANİZOR KURAL Birgül,UYDU HÜSEYİN AVNİ The effects of royal jelly on the oxidantantioxidant system in rats with N-methyl- N-nitrosourea-induced breast cancer. (2018): 176 - 183. 10.1515/tjb-2017-0140 |
| MLA | Malkoç Meltem,us altay diler,Alver Ahmet,ERSÖZ Şafak,ŞEN Tuğba Mazlum,VANİZOR KURAL Birgül,UYDU HÜSEYİN AVNİ The effects of royal jelly on the oxidantantioxidant system in rats with N-methyl- N-nitrosourea-induced breast cancer. , 2018, ss.176 - 183. 10.1515/tjb-2017-0140 |
| AMA | Malkoç M,us altay d,Alver A,ERSÖZ Ş,ŞEN T,VANİZOR KURAL B,UYDU H The effects of royal jelly on the oxidantantioxidant system in rats with N-methyl- N-nitrosourea-induced breast cancer. . 2018; 176 - 183. 10.1515/tjb-2017-0140 |
| Vancouver | Malkoç M,us altay d,Alver A,ERSÖZ Ş,ŞEN T,VANİZOR KURAL B,UYDU H The effects of royal jelly on the oxidantantioxidant system in rats with N-methyl- N-nitrosourea-induced breast cancer. . 2018; 176 - 183. 10.1515/tjb-2017-0140 |
| IEEE | Malkoç M,us altay d,Alver A,ERSÖZ Ş,ŞEN T,VANİZOR KURAL B,UYDU H "The effects of royal jelly on the oxidantantioxidant system in rats with N-methyl- N-nitrosourea-induced breast cancer." , ss.176 - 183, 2018. 10.1515/tjb-2017-0140 |
| ISNAD | Malkoç, Meltem vd. "The effects of royal jelly on the oxidantantioxidant system in rats with N-methyl- N-nitrosourea-induced breast cancer". (2018), 176-183. https://doi.org/10.1515/tjb-2017-0140 |
| APA | Malkoç M, us altay d, Alver A, ERSÖZ Ş, ŞEN T, VANİZOR KURAL B, UYDU H (2018). The effects of royal jelly on the oxidantantioxidant system in rats with N-methyl- N-nitrosourea-induced breast cancer. Türk Biyokimya Dergisi, 43(2), 176 - 183. 10.1515/tjb-2017-0140 |
| Chicago | Malkoç Meltem,us altay diler,Alver Ahmet,ERSÖZ Şafak,ŞEN Tuğba Mazlum,VANİZOR KURAL Birgül,UYDU HÜSEYİN AVNİ The effects of royal jelly on the oxidantantioxidant system in rats with N-methyl- N-nitrosourea-induced breast cancer. Türk Biyokimya Dergisi 43, no.2 (2018): 176 - 183. 10.1515/tjb-2017-0140 |
| MLA | Malkoç Meltem,us altay diler,Alver Ahmet,ERSÖZ Şafak,ŞEN Tuğba Mazlum,VANİZOR KURAL Birgül,UYDU HÜSEYİN AVNİ The effects of royal jelly on the oxidantantioxidant system in rats with N-methyl- N-nitrosourea-induced breast cancer. Türk Biyokimya Dergisi, vol.43, no.2, 2018, ss.176 - 183. 10.1515/tjb-2017-0140 |
| AMA | Malkoç M,us altay d,Alver A,ERSÖZ Ş,ŞEN T,VANİZOR KURAL B,UYDU H The effects of royal jelly on the oxidantantioxidant system in rats with N-methyl- N-nitrosourea-induced breast cancer. Türk Biyokimya Dergisi. 2018; 43(2): 176 - 183. 10.1515/tjb-2017-0140 |
| Vancouver | Malkoç M,us altay d,Alver A,ERSÖZ Ş,ŞEN T,VANİZOR KURAL B,UYDU H The effects of royal jelly on the oxidantantioxidant system in rats with N-methyl- N-nitrosourea-induced breast cancer. Türk Biyokimya Dergisi. 2018; 43(2): 176 - 183. 10.1515/tjb-2017-0140 |
| IEEE | Malkoç M,us altay d,Alver A,ERSÖZ Ş,ŞEN T,VANİZOR KURAL B,UYDU H "The effects of royal jelly on the oxidantantioxidant system in rats with N-methyl- N-nitrosourea-induced breast cancer." Türk Biyokimya Dergisi, 43, ss.176 - 183, 2018. 10.1515/tjb-2017-0140 |
| ISNAD | Malkoç, Meltem vd. "The effects of royal jelly on the oxidantantioxidant system in rats with N-methyl- N-nitrosourea-induced breast cancer". Türk Biyokimya Dergisi 43/2 (2018), 176-183. https://doi.org/10.1515/tjb-2017-0140 |
