The effect of surgical specimen-derived phosphorus and lead concentrations in non-small cell lung cancer patients on disease course
Yıl: 2018 Cilt: 66 Sayı: 4 Sayfa Aralığı: 334 - 339 Metin Dili: İngilizce DOI: 10.5578/tt.67834 İndeks Tarihi: 02-07-2019
The effect of surgical specimen-derived phosphorus and lead concentrations in non-small cell lung cancer patients on disease course
Öz: Introduction: Lung cancer is one of the leading causes of cancer-related mortality. There are many exogenic and endogenic factorsassociated with the development of lung cancer. One of these factors is trace elements. Under- or overabundance of trace elementscan disrupt cellular functions and lead to the formation of cancer. In this study we conducted elemental analysis of lung cancer tissueand normal lung tissue to investigate the role of tissue trace element concentrations in lung cancer.Materials and Methods: Elemental analysis was performed on 30 lung cancer tissue samples and a control group of 15 normal lungtissue samples, all taken from patients diagnosed, treated and followed at our hospital between 2005 and 2010. The solubilized tissuesamples were analyzed for the presence of 19 elements using inductively coupled plasma-optical emission spectroscopy (ICP-OES).Total element amounts in the tissue were calculated.Results: Concentrations of magnesium, potassium, zinc, manganese,lead, boron, chromium and phosphorus were significantly higher inthe patient group compared to the control group. Deceasedpatients had significantly lower phosphorus concentrations andsignificantly higher lead concentrations than the other patients.Conclusion: Elevated levels of magnesium, potassium, zinc, manganese, lead, boron, chromium and phosphorus in lung cancer tissue indicate that these elements may play a role in the development of lung cancer. The results of our evaluation of the associationbetween trace elements and lung cancer suggest that, together with other factors, low phosphorus concentration and high leadconcentration in tumor tissue may influence disease course.
Anahtar Kelime: Konular:
Küçük hücreli dışı akciğer kanseri hastalarında, cerrahi materyalden tespit edilen fosfor ve kurşun düzeylerinin hastalığın seyrine etkisi
Öz: Giriş: Akciğer kanseri, kansere bağlı ölümlerin en sık sebeplerinden biridir. Akciğer kanserinin oluşumu ve gelişmesi ile ilişkili pek çok ekzojen ve endojen faktör vardır. Bu faktörlerden biri olan eser elementler, vücut dokularında düşük konsantrasyonlarda bulunmalarına rağmen önemli biyolojik fonksiyonlarda görev yaparlar ve bunların yetersiz ya da aşırı alınımı, hücresel fonksiyonları bozarak, kanser oluşumuna sebep olurlar. Bu çalışmada, akciğer kanserli dokular ile normal akciğer dokularının elementel analizi yapılarak, dokulardaki element konsantrasyonlarının akciğer kanserindeki rolü araştırıldı. Materyal ve Metod: Çalışmada 30 akciğer kanserli doku ile kontrol grubu olarak 15 normal akciğer dokusunun element analizi yapıldı. Parafin bloklara gömülü olan doku örneklerinin numune hazırlama sürecinden sonra Inductively Coupled Plasma-Optical Emission Spectroscopy (ICP-OES) cihazı ile 19 elementin analizi yapıldı. Olgular 2005-2010 yılları arasında tanı konulan, tedavi ve takibi hastanemizde yapılan hastalardı. Bulgular: Çalışmamızda magnezyum, potasyum, çinko, manganez, kurşun, bor, krom ve fosfor konsantrasyonları hasta grubunda kontrol grubuna göre anlamlı şekilde yüksek bulundu. Ölen hastalarda diğer hastalar karşılaştırıldığında anlamlı oranda fosfor miktarı düşük ve kurşun konsantrasyonu ise yüksek bulundu. Sonuç: Akciğer kanserinin oluşumu ve gelişiminde elementlerin rolünü değerlendirdiğimiz bu çalışmada elde ettiğimiz sonuçlar göz önüne alındığında; kanser dokusundaki fosfor konsantrasyonu düşüklüğü ve kurşun konsantrasyonu yüksekliği diğer faktörler ile birlikte hastalığın seyrinde etkili olabileceği düşünülebilir.
Anahtar Kelime: Konular:
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | Aras O, araz a, YILMAZEL UÇAR E, DEMİRCİ E, Aydin Y, Akgün M (2018). The effect of surgical specimen-derived phosphorus and lead concentrations in non-small cell lung cancer patients on disease course. , 334 - 339. 10.5578/tt.67834 |
| Chicago | Aras Omer,araz aslı,YILMAZEL UÇAR Elif,DEMİRCİ ELİF,Aydin Yener,Akgün Metin The effect of surgical specimen-derived phosphorus and lead concentrations in non-small cell lung cancer patients on disease course. (2018): 334 - 339. 10.5578/tt.67834 |
| MLA | Aras Omer,araz aslı,YILMAZEL UÇAR Elif,DEMİRCİ ELİF,Aydin Yener,Akgün Metin The effect of surgical specimen-derived phosphorus and lead concentrations in non-small cell lung cancer patients on disease course. , 2018, ss.334 - 339. 10.5578/tt.67834 |
| AMA | Aras O,araz a,YILMAZEL UÇAR E,DEMİRCİ E,Aydin Y,Akgün M The effect of surgical specimen-derived phosphorus and lead concentrations in non-small cell lung cancer patients on disease course. . 2018; 334 - 339. 10.5578/tt.67834 |
| Vancouver | Aras O,araz a,YILMAZEL UÇAR E,DEMİRCİ E,Aydin Y,Akgün M The effect of surgical specimen-derived phosphorus and lead concentrations in non-small cell lung cancer patients on disease course. . 2018; 334 - 339. 10.5578/tt.67834 |
| IEEE | Aras O,araz a,YILMAZEL UÇAR E,DEMİRCİ E,Aydin Y,Akgün M "The effect of surgical specimen-derived phosphorus and lead concentrations in non-small cell lung cancer patients on disease course." , ss.334 - 339, 2018. 10.5578/tt.67834 |
| ISNAD | Aras, Omer vd. "The effect of surgical specimen-derived phosphorus and lead concentrations in non-small cell lung cancer patients on disease course". (2018), 334-339. https://doi.org/10.5578/tt.67834 |
| APA | Aras O, araz a, YILMAZEL UÇAR E, DEMİRCİ E, Aydin Y, Akgün M (2018). The effect of surgical specimen-derived phosphorus and lead concentrations in non-small cell lung cancer patients on disease course. Tüberküloz ve Toraks, 66(4), 334 - 339. 10.5578/tt.67834 |
| Chicago | Aras Omer,araz aslı,YILMAZEL UÇAR Elif,DEMİRCİ ELİF,Aydin Yener,Akgün Metin The effect of surgical specimen-derived phosphorus and lead concentrations in non-small cell lung cancer patients on disease course. Tüberküloz ve Toraks 66, no.4 (2018): 334 - 339. 10.5578/tt.67834 |
| MLA | Aras Omer,araz aslı,YILMAZEL UÇAR Elif,DEMİRCİ ELİF,Aydin Yener,Akgün Metin The effect of surgical specimen-derived phosphorus and lead concentrations in non-small cell lung cancer patients on disease course. Tüberküloz ve Toraks, vol.66, no.4, 2018, ss.334 - 339. 10.5578/tt.67834 |
| AMA | Aras O,araz a,YILMAZEL UÇAR E,DEMİRCİ E,Aydin Y,Akgün M The effect of surgical specimen-derived phosphorus and lead concentrations in non-small cell lung cancer patients on disease course. Tüberküloz ve Toraks. 2018; 66(4): 334 - 339. 10.5578/tt.67834 |
| Vancouver | Aras O,araz a,YILMAZEL UÇAR E,DEMİRCİ E,Aydin Y,Akgün M The effect of surgical specimen-derived phosphorus and lead concentrations in non-small cell lung cancer patients on disease course. Tüberküloz ve Toraks. 2018; 66(4): 334 - 339. 10.5578/tt.67834 |
| IEEE | Aras O,araz a,YILMAZEL UÇAR E,DEMİRCİ E,Aydin Y,Akgün M "The effect of surgical specimen-derived phosphorus and lead concentrations in non-small cell lung cancer patients on disease course." Tüberküloz ve Toraks, 66, ss.334 - 339, 2018. 10.5578/tt.67834 |
| ISNAD | Aras, Omer vd. "The effect of surgical specimen-derived phosphorus and lead concentrations in non-small cell lung cancer patients on disease course". Tüberküloz ve Toraks 66/4 (2018), 334-339. https://doi.org/10.5578/tt.67834 |
