Investigation of GLUT1, HIF1α and TBX21 Gene Polymorphisms in Laryngeal Cancer
Yıl: 2018 Cilt: 56 Sayı: 2 Sayfa Aralığı: 70 - 74 Metin Dili: İngilizce DOI: 10.5152/tao.2018.3177 İndeks Tarihi: 16-07-2019
Investigation of GLUT1, HIF1α and TBX21 Gene Polymorphisms in Laryngeal Cancer
Öz: Objective: We aimed to investigate the associationof the frequency of three single-nucleotide polymorphisms [glucose transporter isoform 1 (GLUT1) reference single-nucleotide polymorphism (rs) 710218,hypoxia-inducible factor 1 alpha (HIF1α) rs11549465,and T-box transcription factor protein 21 (TBX21)rs17250932], which have been proved to be relatedwith various benign and malignant diseases, with thedevelopment of laryngeal cancer and its size and grade.Methods: In this study, we included 35 patients withlaryngeal cancer and 35 volunteers at least 30 yearsold who had smoked for at least 20 years. DNA wasobtained from the blood samples of the participantsusing an isolation kit. Then, polymorphisms for boththe groups were determined using real-time polymerase chain reaction.Results: No significant differences were detected regarding the genotype and allele frequencies inthe three polymorphisms assessed between the twogroups. In the patient group, on examining the association of polymorphisms with tumor size and grade,no significant relation was observed in three polymorphisms regarding the related parameters.Conclusion: GLUT1, HIF1α, and TBX21 polymorphisms have no impact on the development of laryngeal cancer.
Anahtar Kelime: Konular:
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | USLU C, TÜZ M, YASAN H, Okur E (2018). Investigation of GLUT1, HIF1α and TBX21 Gene Polymorphisms in Laryngeal Cancer. , 70 - 74. 10.5152/tao.2018.3177 |
| Chicago | USLU Cihan,TÜZ Mustafa,YASAN Hasan,Okur Erdogan Investigation of GLUT1, HIF1α and TBX21 Gene Polymorphisms in Laryngeal Cancer. (2018): 70 - 74. 10.5152/tao.2018.3177 |
| MLA | USLU Cihan,TÜZ Mustafa,YASAN Hasan,Okur Erdogan Investigation of GLUT1, HIF1α and TBX21 Gene Polymorphisms in Laryngeal Cancer. , 2018, ss.70 - 74. 10.5152/tao.2018.3177 |
| AMA | USLU C,TÜZ M,YASAN H,Okur E Investigation of GLUT1, HIF1α and TBX21 Gene Polymorphisms in Laryngeal Cancer. . 2018; 70 - 74. 10.5152/tao.2018.3177 |
| Vancouver | USLU C,TÜZ M,YASAN H,Okur E Investigation of GLUT1, HIF1α and TBX21 Gene Polymorphisms in Laryngeal Cancer. . 2018; 70 - 74. 10.5152/tao.2018.3177 |
| IEEE | USLU C,TÜZ M,YASAN H,Okur E "Investigation of GLUT1, HIF1α and TBX21 Gene Polymorphisms in Laryngeal Cancer." , ss.70 - 74, 2018. 10.5152/tao.2018.3177 |
| ISNAD | USLU, Cihan vd. "Investigation of GLUT1, HIF1α and TBX21 Gene Polymorphisms in Laryngeal Cancer". (2018), 70-74. https://doi.org/10.5152/tao.2018.3177 |
| APA | USLU C, TÜZ M, YASAN H, Okur E (2018). Investigation of GLUT1, HIF1α and TBX21 Gene Polymorphisms in Laryngeal Cancer. Türk Otorinolarengoloji Arşivi, 56(2), 70 - 74. 10.5152/tao.2018.3177 |
| Chicago | USLU Cihan,TÜZ Mustafa,YASAN Hasan,Okur Erdogan Investigation of GLUT1, HIF1α and TBX21 Gene Polymorphisms in Laryngeal Cancer. Türk Otorinolarengoloji Arşivi 56, no.2 (2018): 70 - 74. 10.5152/tao.2018.3177 |
| MLA | USLU Cihan,TÜZ Mustafa,YASAN Hasan,Okur Erdogan Investigation of GLUT1, HIF1α and TBX21 Gene Polymorphisms in Laryngeal Cancer. Türk Otorinolarengoloji Arşivi, vol.56, no.2, 2018, ss.70 - 74. 10.5152/tao.2018.3177 |
| AMA | USLU C,TÜZ M,YASAN H,Okur E Investigation of GLUT1, HIF1α and TBX21 Gene Polymorphisms in Laryngeal Cancer. Türk Otorinolarengoloji Arşivi. 2018; 56(2): 70 - 74. 10.5152/tao.2018.3177 |
| Vancouver | USLU C,TÜZ M,YASAN H,Okur E Investigation of GLUT1, HIF1α and TBX21 Gene Polymorphisms in Laryngeal Cancer. Türk Otorinolarengoloji Arşivi. 2018; 56(2): 70 - 74. 10.5152/tao.2018.3177 |
| IEEE | USLU C,TÜZ M,YASAN H,Okur E "Investigation of GLUT1, HIF1α and TBX21 Gene Polymorphisms in Laryngeal Cancer." Türk Otorinolarengoloji Arşivi, 56, ss.70 - 74, 2018. 10.5152/tao.2018.3177 |
| ISNAD | USLU, Cihan vd. "Investigation of GLUT1, HIF1α and TBX21 Gene Polymorphisms in Laryngeal Cancer". Türk Otorinolarengoloji Arşivi 56/2 (2018), 70-74. https://doi.org/10.5152/tao.2018.3177 |
