The Significance of Extent of Extracapsular Extension in Patients with T1-2 and N1 Breast Cancer
Yıl: 2018 Cilt: 14 Sayı: 4 Sayfa Aralığı: 218 - 224 Metin Dili: İngilizce DOI: 10.5152/ejbh.2018.4038 İndeks Tarihi: 23-07-2019
The Significance of Extent of Extracapsular Extension in Patients with T1-2 and N1 Breast Cancer
Öz: Objective: The prognostic importance of extracapsular extension (ECE) in breast cancer is not yet clear, especially in patients with pathologicalT1-2 and N1 (pT1-2N1) disease. We aimed to investigate whether the extent of ECE was an independent prognostic factor for survival outcomesin patients with pT1-2N1 breast cancer.Materials and Methods: A total number of 131 patients with pT1-2N1 breast cancer treated between 2009 and 2015 were retrospectively evaluated. A single pathologist re-analyzed the histologic examples of all cases. The extent of ECE was graded from 0 to 4.Results: There was a significant correlation between the number of lymph nodes involved and ECE grade (p=0.004). According to the univariateanalysis, lymphovascular invasion (LVI) and ECE grade were the significant prognostic factors for overall survival (OS); age, number of metastaticlymph nodes, menopausal status, and ECE grade were the prognostic factors for disease-free survival (DFS). With a median follow-up of 46 months,grade 3-4 ECE seems to be notably associated with a shorter OS and DFS in multivariate analysis. The mean OS was 85 months for the patients withgrade 0-2 ECE vs 75 months for the patients with grade 3-4 ECE (p=0.003). The mean DFS was 83 months for the patients with grade 0-3 ECE vs68 months for the patients with grade 4 ECE (p=<0.0001).Conclusion: This research has shown that the extent of ECE is an important prognostic factor for survival in pT1-2N1 breast cancer patients andgrade 3-4 ECE seems to be notably associated with a shorter OS and DFS.
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Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | KANYİLMAZ G, FINDIK S, BENLİ YAVUZ B, AKTAN M (2018). The Significance of Extent of Extracapsular Extension in Patients with T1-2 and N1 Breast Cancer. , 218 - 224. 10.5152/ejbh.2018.4038 |
| Chicago | KANYİLMAZ Gul,FINDIK Sıddıka,BENLİ YAVUZ Berrin,AKTAN Meryem The Significance of Extent of Extracapsular Extension in Patients with T1-2 and N1 Breast Cancer. (2018): 218 - 224. 10.5152/ejbh.2018.4038 |
| MLA | KANYİLMAZ Gul,FINDIK Sıddıka,BENLİ YAVUZ Berrin,AKTAN Meryem The Significance of Extent of Extracapsular Extension in Patients with T1-2 and N1 Breast Cancer. , 2018, ss.218 - 224. 10.5152/ejbh.2018.4038 |
| AMA | KANYİLMAZ G,FINDIK S,BENLİ YAVUZ B,AKTAN M The Significance of Extent of Extracapsular Extension in Patients with T1-2 and N1 Breast Cancer. . 2018; 218 - 224. 10.5152/ejbh.2018.4038 |
| Vancouver | KANYİLMAZ G,FINDIK S,BENLİ YAVUZ B,AKTAN M The Significance of Extent of Extracapsular Extension in Patients with T1-2 and N1 Breast Cancer. . 2018; 218 - 224. 10.5152/ejbh.2018.4038 |
| IEEE | KANYİLMAZ G,FINDIK S,BENLİ YAVUZ B,AKTAN M "The Significance of Extent of Extracapsular Extension in Patients with T1-2 and N1 Breast Cancer." , ss.218 - 224, 2018. 10.5152/ejbh.2018.4038 |
| ISNAD | KANYİLMAZ, Gul vd. "The Significance of Extent of Extracapsular Extension in Patients with T1-2 and N1 Breast Cancer". (2018), 218-224. https://doi.org/10.5152/ejbh.2018.4038 |
| APA | KANYİLMAZ G, FINDIK S, BENLİ YAVUZ B, AKTAN M (2018). The Significance of Extent of Extracapsular Extension in Patients with T1-2 and N1 Breast Cancer. European Journal of Breast Health, 14(4), 218 - 224. 10.5152/ejbh.2018.4038 |
| Chicago | KANYİLMAZ Gul,FINDIK Sıddıka,BENLİ YAVUZ Berrin,AKTAN Meryem The Significance of Extent of Extracapsular Extension in Patients with T1-2 and N1 Breast Cancer. European Journal of Breast Health 14, no.4 (2018): 218 - 224. 10.5152/ejbh.2018.4038 |
| MLA | KANYİLMAZ Gul,FINDIK Sıddıka,BENLİ YAVUZ Berrin,AKTAN Meryem The Significance of Extent of Extracapsular Extension in Patients with T1-2 and N1 Breast Cancer. European Journal of Breast Health, vol.14, no.4, 2018, ss.218 - 224. 10.5152/ejbh.2018.4038 |
| AMA | KANYİLMAZ G,FINDIK S,BENLİ YAVUZ B,AKTAN M The Significance of Extent of Extracapsular Extension in Patients with T1-2 and N1 Breast Cancer. European Journal of Breast Health. 2018; 14(4): 218 - 224. 10.5152/ejbh.2018.4038 |
| Vancouver | KANYİLMAZ G,FINDIK S,BENLİ YAVUZ B,AKTAN M The Significance of Extent of Extracapsular Extension in Patients with T1-2 and N1 Breast Cancer. European Journal of Breast Health. 2018; 14(4): 218 - 224. 10.5152/ejbh.2018.4038 |
| IEEE | KANYİLMAZ G,FINDIK S,BENLİ YAVUZ B,AKTAN M "The Significance of Extent of Extracapsular Extension in Patients with T1-2 and N1 Breast Cancer." European Journal of Breast Health, 14, ss.218 - 224, 2018. 10.5152/ejbh.2018.4038 |
| ISNAD | KANYİLMAZ, Gul vd. "The Significance of Extent of Extracapsular Extension in Patients with T1-2 and N1 Breast Cancer". European Journal of Breast Health 14/4 (2018), 218-224. https://doi.org/10.5152/ejbh.2018.4038 |
