Yıl: 2018 Cilt: 5 Sayı: 3 Sayfa Aralığı: 118 - 123 Metin Dili: İngilizce DOI: 10.4274/jpr.66588 İndeks Tarihi: 30-07-2019

The Effect of Exercise on Bone Mineral Density in Patients with Down Syndrome

Öz:
Aim: Down syndrome (DS) is a predisposing factor for osteoporosis. The aim of this study is to investigate the effect of resistance and jumpingexercises on the bone mineral density (BMD) and bone mineral content (BMC) of patients with DS.Materials and Methods: DS and normal individuals aged between 10 and 30 years old were randomized into an exercise group and a control group: aDS without-exercise group (n=15), DS exercise group (n=17), control without-exercise group (n=18), and control exercise group (n=20) were designated.A supervised 45-minute period of exercise was given to the DS exercise group and control exercise group three times per week for six months. Thelumbar total and femoral neck BMD and BMC were measured both before and after six months of exercise using dual-energy X-ray absorptiometry.Results: The change in BMD and BMC over six months did not differ significantly between the exercise and control groups. The BMD and BMC of theDS exercise group decreased in the vertebral and femur areas over six months. The study on resistance and jumping exercises over six months did notlead to a significant change in the total BMD and BMC in the vertebral and femoral neck areas of the patients with DS.Conclusion: The decrease in BMD and BMC over six months in the DS exercise group is not a predictable result.
Anahtar Kelime:

Konular: Pediatri
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
  • Vlachopoulos D, Barker AR, Williams CA, et al. Effect of a program of short bouts of exercise on bone health in adolescents involved in different sports: the PRO-BONE study protocol. BMC public health 2015;15:361.
  • Hayes A, Batshaw ML. Down syndrome. Pediatric clinics of North America 1993;40:523-35.
  • Kao CH, Chen CC, Wang SJ, Yeh SH. Bone mineral density in children with Down’s syndrome detected by dual photon absorptiometry. Send to Nucl Med Commun 1992;13:773-5.
  • Frost HM. Bone’s mechanostat: a 2003 update. Anat Rec A Discov Mol Cell Evol Biol 2003;275:1081-101.
  • Kelley GA, Kelley KS, Tran ZV. Resistance training and bone mineral density in women: a meta-analysis of controlled trials. Am J Phys Med Rehabil 2001;80:65-77.
  • Burrows M. Exercise and bone mineral accrual in children and adolescents. J Sports Sci Med 2007;6:305-12.
  • Heinrich CH, Going SB, Pamenter RW, et al. Bone mineral content of cyclically menstruating female resistance and endurance trained athletes. Med Sci Sports Exerc 1990;22:558-63.
  • Angelopoulou N, Souftas V, Sakadamis A, Mandroukas K. Bone mineral density in adults with Down’s syndrome. Eur Radiol 1999;9:648-51.
  • Guijarro M, Valero C, Paule B, Gonzalez-Macias J, Riancho JA. Bone mass in young adults with Down syndrome. J Intellect Disabil Res 2008;52:182-9.
  • Tumer Z, Henriksen AM, Bache I, et al. Eponymous Jacobsen syndrome: mapping the breakpoints of the original family suggests an association between the distal 1.1 Mb of chromosome 21 and osteoporosis in Down syndrome. Am J Med Genet A 2005;135:339-41.
  • Angelopoulou N, Matziari C, Tsimaras V, et al. Bone mineral density and muscle strength in young men with mental retardation (with and without Down syndrome). Calcif Tissue Int 2000;66:176-80.
  • Baptista F, Varela A, Sardinha LB. Bone mineral mass in males and females with and without Down syndrome. Osteoporos Int 2005;16:380-8.
  • Matute-Llorente A, González-Agüero A, Gómez-Cabello A, Vicente-Rodríguez G, Casajús JA. Decreased levels of physical activity in adolescents with down syndrome are related with low bone mineral density: a cross-sectional study. BMC Endocr Disord 2013;13:22.
  • Stengel SV, Kemmler W, Pintag R, et al. Power training is more effective than strength training for maintaining bone mineral density in postmenopausal women. J Appl Physiol 2005;99:181-8.
  • Fuchs RK, Bauer JJ, Snow CM. Jumping improves hip and lumbar spine bone mass in prepubescent children: a randomized controlled trial. J Bone Miner Res 2001;16:148-56.
  • Witzke KA, Snow CM. Effects of plyometric jump training on bone mass in adolescent girls. Med Sci Sports Exerc 2000;32:1051-7.
  • Granata KP, Lee PE, Franklin TC. Co-contraction recruitment and spinal load during isometric trunk flexion and extension. Clin Biomech 2005;20:1029-37.
  • Ferry B, Gavris M, Tifrea C, et al. The bone tissue of children and adolescents with Down syndrome is sensitive to mechanical stress in certain skeletal locations: a 1-year physical training program study. Res Dev Disabil 2014;35:2077-84.
  • Nichols DL, Sanborn CF, Love AM. Resistance training and bone mineral density in adolescent females. J Pediatr 2001;139:494- 500.
  • González-Agüero A, Vicente-Rodríguez G, Gómez-Cabello A, et al. A 21-week bone deposition promoting exercise programme increases bone mass in young people with Down syndrome. Dev Med Child Neurol 2012;54:552-6.
  • Chilibeck PD, Paterson DH, Smith WD, Cunningham DA. Cardiorespiratory kinetics during exercise of different muscle groups and mass in old and young. J Appl Physiol 1996;81:1388-94.
  • Soomro RR, Ahmed SI, Khan M, Ali SS. Comparing the effects of Osteoporosis Prevention Exercise Protocol (OPEP) versus walking in the prevention of osteoporosis in younger females. Pak J Med Sci 2015;31:336-40.
  • Matute-Llorente A, González-Agüero A, Gómez-Cabello A, et al. Effect of whole-body vibration training on bone mass in adolescents with and without Down syndrome: a randomized controlled trial. Osteoporos Int 2016;27:181-91.
  • Puustjärvi K, Nieminen J, Räsänen T, et al. Do more highly organized collagen fibrils increase bone mechanical strength in loss of mineral density after one-year running training? J Bone Miner Res 1999;14:321-9.
  • Grimwood JS, Kumar A, Bickerstaff DR, Suvarna SK. Histological assessment of vertebral bone in a Down’s syndrome adult with osteoporosis. Histopathology 2000;36:279-80.
  • McKelvey KD, Fowler TW, Akel NS, et al. Low bone turnover and low bone density in a cohort of adults with Down syndrome. Osteoporos Int 2013;24:1333-8.
APA DİLEK G, Ozturk C, HEPGÜLER A, ÖZKINAY F, DİLEK M (2018). The Effect of Exercise on Bone Mineral Density in Patients with Down Syndrome. , 118 - 123. 10.4274/jpr.66588
Chicago DİLEK Gamze,Ozturk Cihat,HEPGÜLER ASİYE SİMİN,ÖZKINAY FERİŞTAH FERDA,DİLEK MUSTAFA The Effect of Exercise on Bone Mineral Density in Patients with Down Syndrome. (2018): 118 - 123. 10.4274/jpr.66588
MLA DİLEK Gamze,Ozturk Cihat,HEPGÜLER ASİYE SİMİN,ÖZKINAY FERİŞTAH FERDA,DİLEK MUSTAFA The Effect of Exercise on Bone Mineral Density in Patients with Down Syndrome. , 2018, ss.118 - 123. 10.4274/jpr.66588
AMA DİLEK G,Ozturk C,HEPGÜLER A,ÖZKINAY F,DİLEK M The Effect of Exercise on Bone Mineral Density in Patients with Down Syndrome. . 2018; 118 - 123. 10.4274/jpr.66588
Vancouver DİLEK G,Ozturk C,HEPGÜLER A,ÖZKINAY F,DİLEK M The Effect of Exercise on Bone Mineral Density in Patients with Down Syndrome. . 2018; 118 - 123. 10.4274/jpr.66588
IEEE DİLEK G,Ozturk C,HEPGÜLER A,ÖZKINAY F,DİLEK M "The Effect of Exercise on Bone Mineral Density in Patients with Down Syndrome." , ss.118 - 123, 2018. 10.4274/jpr.66588
ISNAD DİLEK, Gamze vd. "The Effect of Exercise on Bone Mineral Density in Patients with Down Syndrome". (2018), 118-123. https://doi.org/10.4274/jpr.66588
APA DİLEK G, Ozturk C, HEPGÜLER A, ÖZKINAY F, DİLEK M (2018). The Effect of Exercise on Bone Mineral Density in Patients with Down Syndrome. The Journal of Pediatric Research, 5(3), 118 - 123. 10.4274/jpr.66588
Chicago DİLEK Gamze,Ozturk Cihat,HEPGÜLER ASİYE SİMİN,ÖZKINAY FERİŞTAH FERDA,DİLEK MUSTAFA The Effect of Exercise on Bone Mineral Density in Patients with Down Syndrome. The Journal of Pediatric Research 5, no.3 (2018): 118 - 123. 10.4274/jpr.66588
MLA DİLEK Gamze,Ozturk Cihat,HEPGÜLER ASİYE SİMİN,ÖZKINAY FERİŞTAH FERDA,DİLEK MUSTAFA The Effect of Exercise on Bone Mineral Density in Patients with Down Syndrome. The Journal of Pediatric Research, vol.5, no.3, 2018, ss.118 - 123. 10.4274/jpr.66588
AMA DİLEK G,Ozturk C,HEPGÜLER A,ÖZKINAY F,DİLEK M The Effect of Exercise on Bone Mineral Density in Patients with Down Syndrome. The Journal of Pediatric Research. 2018; 5(3): 118 - 123. 10.4274/jpr.66588
Vancouver DİLEK G,Ozturk C,HEPGÜLER A,ÖZKINAY F,DİLEK M The Effect of Exercise on Bone Mineral Density in Patients with Down Syndrome. The Journal of Pediatric Research. 2018; 5(3): 118 - 123. 10.4274/jpr.66588
IEEE DİLEK G,Ozturk C,HEPGÜLER A,ÖZKINAY F,DİLEK M "The Effect of Exercise on Bone Mineral Density in Patients with Down Syndrome." The Journal of Pediatric Research, 5, ss.118 - 123, 2018. 10.4274/jpr.66588
ISNAD DİLEK, Gamze vd. "The Effect of Exercise on Bone Mineral Density in Patients with Down Syndrome". The Journal of Pediatric Research 5/3 (2018), 118-123. https://doi.org/10.4274/jpr.66588