Aim: Migraine headaches are one of the serious complaints of patients seeking emergency department (ED) with symptoms of manyhealth problems. In this study, we aimed to examine predictive values of hematological parameters on chronic migraine.Material and Methods: The files of patients admitted to ED of Ufuk University Hospital between January 2016 and November 2016with a headache and who underwent hematological analyses at emergency admission were analyzed retrospectively. After exclusioncriteria were applied, 55 patients with migraine attacks who were previously diagnosed with migraine by a neurologist included inthis study.Results: There was not a statistically significant difference between age and sex distribution of groups (p>0.05), whereas astatistically significant difference was found for family history between patient and control groups (p<0.05). Attack frequency wasabove 3 in most patients (74.5%), and mean migraine duration was 9.00±9.49 years. Red blood cell count (RBC), hemoglobin andhematocrit levels of patient groups were significantly higher than the control groups (p<0.05). Receiver operating characteristic(ROC) analysis showed that hematocrit was the most important parameter for migraine, followed by RBC and hemoglobin. In binarylogistic regression analysis, high hematocrit level is an effective factor for migraine with controlled multi-parameter regressionanalysis (OR=0.601; p<0.05).Conclusion: The results of this study show that hematocrit levels of patients can be used to predict or distinguish migraine attack inED in order to provide fast and correct treatment.Keywords: Migraine; pain; headache; hematocrit; emergency