Association of Tumor Necrosis Factor Alpha -238G/A and -308G/A Promotor Polymorphisms with Clearance of Hepatitis B Virus Infection in Turkish Population

ERAYMAN, İbrahim; Bitirgen, Mehmet; TÜRK ARIBAŞ, Emel; Kandemir, Bahar; Acar, Hasan; İNKAYA, AHMET ÇAĞKAN

Association of Tumor Necrosis Factor Alpha -238G/A and -308G/A Promotor Polymorphisms with Clearance of Hepatitis B Virus Infection in Turkish Population

Ahmet Çağkan İNKAYA, (Hacettepe Üniversitesi)

Emel TÜRK ARIBAŞ, (Necmettin Erbakan Üniversitesi)

İbrahim ERAYMAN, (Necmettin Erbakan Üniversitesi)

Bahar KANDEMİR, (Necmettin Erbakan Üniversitesi)

Hasan ACAR, (Necmettin Erbakan Üniversitesi)

Mehmet BİTİRGEN (Necmettin Erbakan Üniversitesi)

Acta Medica

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Yıl: 2019 Cilt: 50 Sayı: 1 Sayfa Aralığı: 1 - 6 Metin Dili: İngilizce İndeks Tarihi: 29-11-2019

Association of Tumor Necrosis Factor Alpha -238G/A and -308G/A Promotor Polymorphisms with Clearance of Hepatitis B Virus Infection in Turkish Population

Öz:

Objectives: Acute viral hepatitis B may lead to chronic hepatitis in 6% of adultpopulation. We compared the frequency of Tumor necrosis factor alpha promotor polymorphisms in chronic hepatitis B patients and people with natural immunity against hepatitis B.Materials and Methods: Chronic hepatitis B patients and age matched control cases with natural immunity to hepatitis B virus were recruited 1:1 in this study. Tumornecrosis factor alpha -238G/A and -308G/A polymorphisms were studied withPCR-RFLP. χ2 test was performed in statistical analysis.Results: A total of 101 volunteers enrolled in two study groups. Thirty-eight menand 12 women constituted the chronic hepatitis B patient group and 40 men and11 women recruited in natural immunity group. Frequency of -238G allele was87.5% and 97% in chronic hepatitis B and natural immunity groups, respectively.Frequency of -308G allel was 93% and 92.1% in chronic hepatitis B and natural im-munity groups, respectively. Frequencies of polymorphisms at positions -238 and-308 in the promotor of tumor necrosis factor alpha gene were not different be-tween chronic hepatitis B and natural immunity groups.Discussion: Tumor necrosis factor alpha promoter polymorphisms at -238 and-308 positions do not effect the outcome hepatitis B infection in Turkish population. Clearance of hepatitis B virus infection is multifactorial. Thus, further studiesneeded to identify genetic predisposition to chronic hepatitis B infection.

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Lavanchy D. Hepatitis B virus epidemiology, disease burden, treatment, and current and emerging prevention and control measures. J Viral Hepat 2004; 11: 97-107.
World Health Organization Hepatitis B Fact Sheet No. 204 (Revised October 2000) https://www.who.int/en/news-room/ fact-sheets/detail/hepatitis-a (accessed in July 2018).
Visvanathan K, Lewin SR Immunopathogenesis: Role of Innate and Adaptive Immune Reponses, Semin Liver Dis 2006; 26: 104-15.
Thursz MR, Thomas HC. Pathogenesis of chronic hepatitis B. In: Thomas HC, Lemon S, Zuckermann A (Eds). Viral Hepatitis. Massachusetts; Blackwell Publishing Ltd, 2005; 308-22.
De Franchis R, Hadengue A, Lau G, et al. EASL International Consensus Conference on Hepatitis B. 13-14 September, 2002 Geneva, Switzerland. Consensus statement (long version). J Hepatol 2003; 39(suppl 1): S3-25.
Murray JM, Wieland SF, Purcell RH et al. Dynamics of hepatitis B virus clearance in chimpanzees. Proc Natl Acad Sci USA 2005; 102: 17780–85.
Guidotti LG, Rochford R, Chung J et al. Viral clearance without destruction of infected cells during acute HBV infection. Science 1999; 284: 825–29.
Herbein G, O’Brien WA. Tumor Necrosis Factor (TNF)-α and TNF Receptors in Viral Pathogenesis, PSEBM 2000; 223: 241-57.
Fang JW, Shen WW, Meager A, et al. Activation of the tumor necrosis factor-α system in the liver in chronic hepatitis B virus infection. Am J Gastroenterol 1996; 91:748-53.
Su F, Schneider RJ. Hepatitis B virus x protein sensitizes cells to apoptotic killing by tumor necrosis factor-α. Proc Natl Acad Sci USA 1997; 94: 8744-49.
Romero R, Lavine JE. Cytokine inhibiton of hepatitis B core pro- motor. Hepatology 1996; 23: 17-23.
Tsui L V, Guidotti L G, Ishikawa T, et al. Posttranscriptional clear- ance of hepatitis B virus RNA by cytotoxic T lymphocyte-activat- ed hepatocytes. Proc Natl Acad Sci USA 1995; 92: 12398–402.
Esteve M, Saro C, Gonzalez-Huix F, et al. Chronic hepatitis B reactivation following infliximab therapy in Crohn’s disease patients:need for primary prophylaxis. Gut 2004; 53: 1363–65.
D’Alfonso S, Richiardi PM. A polymorphic variation in a putative regulation box of the TNFA promoter region. Immunogenetics 1994; 39: 150–54.
Louis E, Franchimont D, Piron A, et al. Tumour necrosis factor (TNF) gene polymorphism influences TNF-alpha production in lipopolysaccharide (LPS)-stimulated whole blood cell culture in healthy humans. Clin Exp Immunol 1998; 113: 401–06.
Fernandes H, Koneru B, Fernandes N et al. Investigation of pro- moter polymorphisms in the tumor necrosis factor-alpha and in- terleukin-10 genes in liver transplant patients. Transplantation 2002; 73: 1886–91.
Bayley JP, Ottenhoff THM and Verweij CJ. Is there a future for TNF promoter polymorphisms? Genes and Immunity 2004; 5:315–29.
Louis E, Franchimont D, Piron A, et al. Tumour necrosis factor (TNF) gene polymorphism influences TNF-alpha production in 6 lipopolysaccharide (LPS)-stimulated whole blood cell culture in healthy humans. Clin Exp Immunol 1998; 113: 401–406.
Höhler T, Kruger A, Gerken G, Shneider PP, et al. A tumour necrosis factor alpha (TNFα) promoter polymorphism is associated with chronic hepatitis B infection. Clin Exp Immunol 1998; 111: 579-82.
Miyazoe S, Hamasaki K, Nakata K, et al. Influence of Interleukin 10 gene promotor polimorphisms on disease progression in patients chronically infected with Hepatitis B virus. The American Journal of Gastroenterology 2002; 97: 2086-92.
Lu LP, Li XW, Liu Y, et al. Association of -238G/A polimorphism of tumour necrosis factor alpha gene promoter region with out- comes of hepatitis B virus infection in Chinese Han population. World J Gastroenterol 2004; 10: 1810-14.
Li HQ, Li Z, Liu Y, et al. Association of polymorphism of tumour necrosis factor alpha gene promoter region with outcome of hepatitis B virus infection. World J Gastroenterology 2005; 11: 5213-17.
Du T, Guo XH, Zhu XL et al. Association of TNF-alpha promot- er polymorphisms with the outcomes of hepatitis B virus infection in Chinese Han population. Journal of Viral Hepatitis 2006; 13: 618-24.
Li Chen, Zhi Xin C, Li-Juan Zm, et al. The association between cytokine polimorphisms ant the outcomes of chronic HBV infection. Hepatology Research 2006; 36: 158-66.
Niro GA, Fontana R, Gioffreda D, et al. Tumour necrosis factor gene polymorphisms and clearance or progression of hepatitis B virus infection. Liver International 2005; 25: 1175-81.
Kim YJ, Lee HS, Yoon JH, et al. Association of the TNF-α promoter polymorphisms with the clearance of hepatitis B virus infection Human Molecular Genetics 2003; 12(19): 2541-46.
Mıstık R. Türkiye’de viral hepatit epidemiyolojisi yayınların ird- elenmesi. In: Tabak F, Balık İ, Tekeli E (eds). Viral Hepatit 2007. Viral Hepatitle Savaşım Derneği, İstanbul, Turkey: Ohan Publications, 2006, 10-50.
Höhler T, Geeken G, Notghi A, et al. HLA-DRB1*1301 and 1302 protect against chronic hepatitis B. J Hepatol 1997; 26: 503-07.
[29] Wang C, Tang J, Song W, et al. HLA and cytokine gene poly- morphisms are independently associated with responses to hepatitis B vaccination. Hepatology 2004; 39: 978 –88.
[30] Ozen S, Alikasifoglu M, Bakkaloglu A, et al. Tumor necrosis factor α G→A -238 and G→A -308 polymorphisms in juvenile idio- pathic arthritis. Rheumatology 2002; 41: 223-27.
Karahan ZC, Deda G, Sipahi T, et al. TNF-A —308G/A and IL-6 -174 G/C polymorphisms in the Turkish pediatric stroke patients. Thrombosis Research 2005; 115; 393-98.
Sghaier I, Zidi S, Mouelhi L, et al. The relationship between TNF alpha gene polymorphisms (− 238/− 308), TNF RII VNTR (p75) and outcomes of hepatitis B virus infection in Tunisian popula- tion. Gene 2015; 568: 140-45.
Valaydon Z, Pellegrini M, Thompson A, et al. The role of tumour necrosis factor in hepatitis B infection: Jekyll and Hyde. Clinical & Translational Immunology 2016; 5(12): e115.

APA	İNKAYA A, TÜRK ARIBAŞ E, ERAYMAN İ, Kandemir B, Acar H, Bitirgen M (2019). Association of Tumor Necrosis Factor Alpha -238G/A and -308G/A Promotor Polymorphisms with Clearance of Hepatitis B Virus Infection in Turkish Population. , 1 - 6.
Chicago	İNKAYA AHMET ÇAĞKAN,TÜRK ARIBAŞ Emel,ERAYMAN İbrahim,Kandemir Bahar,Acar Hasan,Bitirgen Mehmet Association of Tumor Necrosis Factor Alpha -238G/A and -308G/A Promotor Polymorphisms with Clearance of Hepatitis B Virus Infection in Turkish Population. (2019): 1 - 6.
MLA	İNKAYA AHMET ÇAĞKAN,TÜRK ARIBAŞ Emel,ERAYMAN İbrahim,Kandemir Bahar,Acar Hasan,Bitirgen Mehmet Association of Tumor Necrosis Factor Alpha -238G/A and -308G/A Promotor Polymorphisms with Clearance of Hepatitis B Virus Infection in Turkish Population. , 2019, ss.1 - 6.
AMA	İNKAYA A,TÜRK ARIBAŞ E,ERAYMAN İ,Kandemir B,Acar H,Bitirgen M Association of Tumor Necrosis Factor Alpha -238G/A and -308G/A Promotor Polymorphisms with Clearance of Hepatitis B Virus Infection in Turkish Population. . 2019; 1 - 6.
Vancouver	İNKAYA A,TÜRK ARIBAŞ E,ERAYMAN İ,Kandemir B,Acar H,Bitirgen M Association of Tumor Necrosis Factor Alpha -238G/A and -308G/A Promotor Polymorphisms with Clearance of Hepatitis B Virus Infection in Turkish Population. . 2019; 1 - 6.
IEEE	İNKAYA A,TÜRK ARIBAŞ E,ERAYMAN İ,Kandemir B,Acar H,Bitirgen M "Association of Tumor Necrosis Factor Alpha -238G/A and -308G/A Promotor Polymorphisms with Clearance of Hepatitis B Virus Infection in Turkish Population." , ss.1 - 6, 2019.
ISNAD	İNKAYA, AHMET ÇAĞKAN vd. "Association of Tumor Necrosis Factor Alpha -238G/A and -308G/A Promotor Polymorphisms with Clearance of Hepatitis B Virus Infection in Turkish Population". (2019), 1-6.

APA	İNKAYA A, TÜRK ARIBAŞ E, ERAYMAN İ, Kandemir B, Acar H, Bitirgen M (2019). Association of Tumor Necrosis Factor Alpha -238G/A and -308G/A Promotor Polymorphisms with Clearance of Hepatitis B Virus Infection in Turkish Population. Acta Medica, 50(1), 1 - 6.
Chicago	İNKAYA AHMET ÇAĞKAN,TÜRK ARIBAŞ Emel,ERAYMAN İbrahim,Kandemir Bahar,Acar Hasan,Bitirgen Mehmet Association of Tumor Necrosis Factor Alpha -238G/A and -308G/A Promotor Polymorphisms with Clearance of Hepatitis B Virus Infection in Turkish Population. Acta Medica 50, no.1 (2019): 1 - 6.
MLA	İNKAYA AHMET ÇAĞKAN,TÜRK ARIBAŞ Emel,ERAYMAN İbrahim,Kandemir Bahar,Acar Hasan,Bitirgen Mehmet Association of Tumor Necrosis Factor Alpha -238G/A and -308G/A Promotor Polymorphisms with Clearance of Hepatitis B Virus Infection in Turkish Population. Acta Medica, vol.50, no.1, 2019, ss.1 - 6.
AMA	İNKAYA A,TÜRK ARIBAŞ E,ERAYMAN İ,Kandemir B,Acar H,Bitirgen M Association of Tumor Necrosis Factor Alpha -238G/A and -308G/A Promotor Polymorphisms with Clearance of Hepatitis B Virus Infection in Turkish Population. Acta Medica. 2019; 50(1): 1 - 6.
Vancouver	İNKAYA A,TÜRK ARIBAŞ E,ERAYMAN İ,Kandemir B,Acar H,Bitirgen M Association of Tumor Necrosis Factor Alpha -238G/A and -308G/A Promotor Polymorphisms with Clearance of Hepatitis B Virus Infection in Turkish Population. Acta Medica. 2019; 50(1): 1 - 6.
IEEE	İNKAYA A,TÜRK ARIBAŞ E,ERAYMAN İ,Kandemir B,Acar H,Bitirgen M "Association of Tumor Necrosis Factor Alpha -238G/A and -308G/A Promotor Polymorphisms with Clearance of Hepatitis B Virus Infection in Turkish Population." Acta Medica, 50, ss.1 - 6, 2019.
ISNAD	İNKAYA, AHMET ÇAĞKAN vd. "Association of Tumor Necrosis Factor Alpha -238G/A and -308G/A Promotor Polymorphisms with Clearance of Hepatitis B Virus Infection in Turkish Population". Acta Medica 50/1 (2019), 1-6.