A Single Center Experience of Parathyroid Carcinoma Which Is Less Common Among Parathyroid Tumors

OZKAN, MURAT BULUT; ÜÇKAN, Enes Malik; ERDOĞAN, AHMET; TEZ, Mesut; Cetinkaya, Erdinc; ŞAHİN, Samet; Özel, Hikmet; Erdoğan, Kübra; Saylam, Barış

A Single Center Experience of Parathyroid Carcinoma Which Is Less Common Among Parathyroid Tumors

Ahmet ERDOĞAN, (Sağlık Bakanlığı)

Erdinç ÇETİNKAYA, (Sağlık Bakanlığı)

Kübra ERDOĞAN, (Kahramanmaraş Elbistan Devlet Hastanesi)

Samet ŞAHİN, (Sağlık Bakanlığı)

Enes Malik ÜÇKAN, (Sağlık Bakanlığı)

Murat Bulut ÖZKAN, (Hitit Üniversitesi)

Hikmet PEHLEVAN, (Sağlık Bakanlığı)

Barış SAYLAM, (Sağlık Bakanlığı)

Mesut TEZ (Sağlık Bakanlığı)

ACTA ONCOLOGICA TURCICA

7 1

Yıl: 2019 Cilt: 52 Sayı: 1 Sayfa Aralığı: 38 - 42 Metin Dili: İngilizce İndeks Tarihi: 04-12-2019

A Single Center Experience of Parathyroid Carcinoma Which Is Less Common Among Parathyroid Tumors

Öz:

INTRODUCTION: Parathyroid tumors can be divided into three groups: parathyroid adenoma, atypicalparathyroid adenoma and parathyroid carcinoma. Parathyroid carcinoma is the less common one among these.Parathyroid carcinomas account for approximately 0,005% of all cancers and 1% of primaryhyperparathyroidism cases. In this study, we wanted to share our experience of parathyroid carcinoma which isnot common.MATERIAL and METHODS: Of 375 patients who were operated with pre-diagnosis of parathyroid adenomain Ankara Numune Training and Research Hospital Department of General Surgery between 2008 and 2015; 12patients whose pathology result could not clearly identify a parathyroid carcinoma and could differentiate acarcinoma from an adenoma were examined retrospectively.RESULTS: Of the patients; 5 (41,6%) were observed to be male and 7 (58,4%) were observed to be female.Mean age was 54,5 (±8,40) and the age range was between 41 and 68. Mean preoperative calcium value was12,3(±1,33) mg/dL and the range was between 10,9 and 15,3. The pathology results were as “a parathyroidcarcinoma” in 4 patients, “a parathyroid neoplasm” in 4 patients, “a parathyroid neoplasm with undeterminedmalignant potential” in 3 patients and “malignancy could not be discarded” in 1 patient. Mean follow-upduration of the patients was 61,8 months (±17,05) and the range was between 35 and 96 months. 1 patientreceived chemotherapy and the same patient died on the month 55 during follow-ups.DISCUSSION AND CONCLUSION: In those with severe preoperative hypocalcemia symptoms, those with acalcium value higher than 14mg/dL, in cases when parathormone level is significantly higher and in cases whenparathyroid gland is palpated, parathyroid carcinomas are suspected. For treatment of a parathyroid carcinoma,neck exploration, en-bloc removal of the tumor and ipsilateral lobectomy of thyroid are required. If pathologyresults are suspicious in regard to malignancy, and then the patient is closely followed-up.

Anahtar Kelime:

Konular: Tıbbi İnformatik Genel ve Dahili Tıp Temel Sağlık Hizmetleri Onkoloji Sağlık Bilimleri ve Hizmetleri

Paratiroid Tümörleri İçerisinde Az Karşılaşılan Paratiroid Karsinomu Tek Merkez Deneyimi

Öz:

GİRİŞ ve AMAÇ: Paratiroid tümörleri; Paratiroid adenomu, atipik paratiroid adenomu ve paratiroid karsinomu şeklinde üç gruba ayrılarak sınıflandırılabilir. Paratiroid karsinomu bunlar içerisinde en az görülenidir. Paratiroid karsinomu, tüm kanserlerin yaklaşık %0,005’ini, primer hiperparatirodi vakalarının ise yaklaşık %1‘ini oluşturur. Biz de bu çalışmada, çok sık rastlanmayan paratiroid karsinomu ile ilgili deneyimimizi paylaşmak istedik. YÖNTEM ve GEREÇLER: Ankara Numune Eğitim Araştırma Hastanesi Genel Cerrahi Servisinde 2008-2015 yılları arasında paratioid adenomu ön tanısı ile opere edilen 375 hasta içerisinden patoloji sonucu paratiroid karsinomu ve karsinom–adenom ayrımı net yapılamayan 12 hasta retrospektif olarak incelendi. BULGULAR: Hastaların 5’i(%41,6) erkek, 7’si(%58,4) kadın olarak izlendi. Yaş ortalaması 54,5 (±8,40) yaş aralığı 41 ile 68 arasındaydı. Preoperatif kalsiyum değeri ortalama 12,3(±1,33) mg/dL ve 10,9 ile 15,3 arasındaydı. Patoloji sonucu; 4 hastanın paratiroid karsinomu, 4 hastanın paratiroid neoplazmı, 3 hastanın malign potansiyeli belirlenemeyen paratiroid neoplazmı, 1 hastanın malignite ekarte edilemedi, şeklinde idi. Hastaların ortalama takip süresi 61,8 ay (±17,05) ve 35 ile 96 ay arasında idi. 1 hasta kemoterapi aldı ve aynı hasta takiplerinde 55. ayda exitus oldu. TARTIŞMA ve SONUÇ: Preoperatif olarak şiddetli hiperkalsemi semptomu olanlarda, kalsiyum değerleri 14mg/dL’den yüksek olanlarda, parathormon seviyesinin anlamlı biçimde yüksek olduğunda ve paratiroid bezinin palpe edildiği durumlarda paratiroid karsinomlarından şüphelenilir. Paratiroid karsinomu tedavisinde boyun eksplorasyonu, tümörün un-blok çıkarılması ve aynı taraf tiroide lobektomi yapılması gerekir. Patoloji sonuçları malignite açısından şüpheli ise yakın takip edilebilir.

Anahtar Kelime:

Konular: Tıbbi İnformatik Genel ve Dahili Tıp Temel Sağlık Hizmetleri Onkoloji Sağlık Bilimleri ve Hizmetleri

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	ERDOĞAN A, Cetinkaya E, Erdoğan K, ŞAHİN S, ÜÇKAN E, OZKAN M, Özel H, Saylam B, TEZ M (2019). A Single Center Experience of Parathyroid Carcinoma Which Is Less Common Among Parathyroid Tumors. , 38 - 42.
Chicago	ERDOĞAN AHMET,Cetinkaya Erdinc,Erdoğan Kübra,ŞAHİN Samet,ÜÇKAN Enes Malik,OZKAN MURAT BULUT,Özel Hikmet,Saylam Barış,TEZ Mesut A Single Center Experience of Parathyroid Carcinoma Which Is Less Common Among Parathyroid Tumors. (2019): 38 - 42.
MLA	ERDOĞAN AHMET,Cetinkaya Erdinc,Erdoğan Kübra,ŞAHİN Samet,ÜÇKAN Enes Malik,OZKAN MURAT BULUT,Özel Hikmet,Saylam Barış,TEZ Mesut A Single Center Experience of Parathyroid Carcinoma Which Is Less Common Among Parathyroid Tumors. , 2019, ss.38 - 42.
AMA	ERDOĞAN A,Cetinkaya E,Erdoğan K,ŞAHİN S,ÜÇKAN E,OZKAN M,Özel H,Saylam B,TEZ M A Single Center Experience of Parathyroid Carcinoma Which Is Less Common Among Parathyroid Tumors. . 2019; 38 - 42.
Vancouver	ERDOĞAN A,Cetinkaya E,Erdoğan K,ŞAHİN S,ÜÇKAN E,OZKAN M,Özel H,Saylam B,TEZ M A Single Center Experience of Parathyroid Carcinoma Which Is Less Common Among Parathyroid Tumors. . 2019; 38 - 42.
IEEE	ERDOĞAN A,Cetinkaya E,Erdoğan K,ŞAHİN S,ÜÇKAN E,OZKAN M,Özel H,Saylam B,TEZ M "A Single Center Experience of Parathyroid Carcinoma Which Is Less Common Among Parathyroid Tumors." , ss.38 - 42, 2019.
ISNAD	ERDOĞAN, AHMET vd. "A Single Center Experience of Parathyroid Carcinoma Which Is Less Common Among Parathyroid Tumors". (2019), 38-42.

APA	ERDOĞAN A, Cetinkaya E, Erdoğan K, ŞAHİN S, ÜÇKAN E, OZKAN M, Özel H, Saylam B, TEZ M (2019). A Single Center Experience of Parathyroid Carcinoma Which Is Less Common Among Parathyroid Tumors. ACTA ONCOLOGICA TURCICA, 52(1), 38 - 42.
Chicago	ERDOĞAN AHMET,Cetinkaya Erdinc,Erdoğan Kübra,ŞAHİN Samet,ÜÇKAN Enes Malik,OZKAN MURAT BULUT,Özel Hikmet,Saylam Barış,TEZ Mesut A Single Center Experience of Parathyroid Carcinoma Which Is Less Common Among Parathyroid Tumors. ACTA ONCOLOGICA TURCICA 52, no.1 (2019): 38 - 42.
MLA	ERDOĞAN AHMET,Cetinkaya Erdinc,Erdoğan Kübra,ŞAHİN Samet,ÜÇKAN Enes Malik,OZKAN MURAT BULUT,Özel Hikmet,Saylam Barış,TEZ Mesut A Single Center Experience of Parathyroid Carcinoma Which Is Less Common Among Parathyroid Tumors. ACTA ONCOLOGICA TURCICA, vol.52, no.1, 2019, ss.38 - 42.
AMA	ERDOĞAN A,Cetinkaya E,Erdoğan K,ŞAHİN S,ÜÇKAN E,OZKAN M,Özel H,Saylam B,TEZ M A Single Center Experience of Parathyroid Carcinoma Which Is Less Common Among Parathyroid Tumors. ACTA ONCOLOGICA TURCICA. 2019; 52(1): 38 - 42.
Vancouver	ERDOĞAN A,Cetinkaya E,Erdoğan K,ŞAHİN S,ÜÇKAN E,OZKAN M,Özel H,Saylam B,TEZ M A Single Center Experience of Parathyroid Carcinoma Which Is Less Common Among Parathyroid Tumors. ACTA ONCOLOGICA TURCICA. 2019; 52(1): 38 - 42.
IEEE	ERDOĞAN A,Cetinkaya E,Erdoğan K,ŞAHİN S,ÜÇKAN E,OZKAN M,Özel H,Saylam B,TEZ M "A Single Center Experience of Parathyroid Carcinoma Which Is Less Common Among Parathyroid Tumors." ACTA ONCOLOGICA TURCICA, 52, ss.38 - 42, 2019.
ISNAD	ERDOĞAN, AHMET vd. "A Single Center Experience of Parathyroid Carcinoma Which Is Less Common Among Parathyroid Tumors". ACTA ONCOLOGICA TURCICA 52/1 (2019), 38-42.