Yıl: 2018 Cilt: 8 Sayı: 1 Sayfa Aralığı: 43 - 50 Metin Dili: Türkçe DOI: 10.5222/buchd.2018.043 İndeks Tarihi: 17-01-2020

Kronik böbrek yetmezliği olan çocuklarda serum leptin konsantrasyonu

Öz:
Amaç: Üremik iştahsızlıkta çeşitli faktörler sorumlu tutulmaktadır. Serum leptindüzeylerinde artış ve üremik toksinler melanokortin hormon reseptörlerini uyararakenerji tüketimini artırıp, yiyecek alımını azaltırlar. Bu çalışmada, kronik böbrekyetmezliği olan çocuklar ile sağlıklı kontrollerin serum leptin konsantrasyonlarınıkarşılaştırarak leptinin böbrek yolu ile atılımını araştırdık.Yöntem: Kronik böbrek yetmezliği nedeniyle takip edilen toplam 33 çocuk hasta vekontrol grubunu oluşturan 29 sağlıklı çocuğun serum leptin, leptin/VKİ, albümin,glikoz, kreatinin, üre, trigliserid ve kolesterol düzeylerini değerlendirdik.Bulgular: Kız hastalarda ortalama serum leptin düzeyi (18,49±28,55), leptin/VKİ(0,94±1,36) kontrol grubu leptin (7,73±5,65) ve leptin/VKİI (0,94±1,36) değerlerine göreyüksekti (p>0,05). Erkek hastalarda ise serum leptin düzeyi (1,48±1,36; 4,88±3,70) veleptin/VKİ kontrole göre (0,08±0,081; 0,25±0,16) düşük bulundu (p<0,01). Kızlardahasta ve sağlıklı grupta serum leptin düzeyi VKİ ile anlamlı pozitif korelasyon gösterirken, erkek hasta grubunda leptin ile VKİ arasında korelasyon bulunmadı. Diyalizerkek hasta grubu dışındaki tüm hastalarda leptin ile glomeruler filtrasyon hızı veserum kreatin düzeyleri arasında korelasyon yoktu. Serum leptin düzeyleri ile yaş,hastalık tanı süresi, diyaliz süresi arasında da korelasyon bulamadık.Sonuç: Serum leptin düzeyleri ile böbrek fonksiyonları arasında bir ilişkinin saptanmaması ve renal yetmezliği olan erkek hastalarda serum leptin konsantrasyonlarınınsağlıklı erkek çocuklardan anlamlı olarak düşük bulunması, leptinin veya reseptörproteinlerinin sentezi veya etkinliğinde ya da böbrek dışı atılımında rol oynayanbaşka etkenlerin de bulunduğunu düşündürmektedir.
Anahtar Kelime:

Konular: Endokrinoloji ve Metabolizma Üroloji ve Nefroloji Pediatri

Serum leptin concentration in children with chronic renal failure

Öz:
Objective: Various factors are responsible for uremic anorexia. Increase in serum leptin levels and uremic toxins stimulate melanocortin hormone receptors to increase energy consumption and reduce food intake. In this study, we investigated renal excretion of leptin by comparing serum leptin concentrations of healthy controls, and children with chronic renal failure. Methods: Serum leptin, leptin / BMI, albumin, glucose, creatinine, urea, triglyceride and cholesterol levels were eveluated in a total of 33 pediatric patients followed up for chronic renal failure and 29 healthy children in the control group. Results: Serum leptin levels (18.49±28.55) and leptin / BMI (0.94±1.36) in female patients were higher than leptin (7.73±5.65) and leptin / BMI (0.39±0.25) in the control group (p>0.05). In male patients, serum leptin levels (1.48±1.36; 4.88±3.70) and leptin/ BMI (0.08±0.081; 0.25±0.16) were found to be lower than those of the control group (p<0,01). Serum leptin levels showed a significant positive correlation with BMI in female patients with chronic renal failure and, healthy women; whilethere was no correlation between leptin and BMI in the male patient group. There was no correlation between leptin and glomerular filtration rate and serum creatinine levels in all patients excepting male dialysis patients. There was no correlation between serum leptin levels and age, time to disease diagnosis, and duration of dialysis. Conclusion: Lack of any correlation between serum leptin levels, and renal functions, and detection of significantly lower serum leptin concentrations in male children with renal failure relative to healthy male children suggest that there might be other factors involved in the synthesis, activity or extrarenal clearance of leptin or its receptor proteins.
Anahtar Kelime:

Konular: Endokrinoloji ve Metabolizma Üroloji ve Nefroloji Pediatri
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA ATAŞ BERKSOY E, ALPAY H, YILDIZ N, USER Y (2018). Kronik böbrek yetmezliği olan çocuklarda serum leptin konsantrasyonu. , 43 - 50. 10.5222/buchd.2018.043
Chicago ATAŞ BERKSOY Emel,ALPAY HARİKA,YILDIZ Nurdan,USER Yasemen Kronik böbrek yetmezliği olan çocuklarda serum leptin konsantrasyonu. (2018): 43 - 50. 10.5222/buchd.2018.043
MLA ATAŞ BERKSOY Emel,ALPAY HARİKA,YILDIZ Nurdan,USER Yasemen Kronik böbrek yetmezliği olan çocuklarda serum leptin konsantrasyonu. , 2018, ss.43 - 50. 10.5222/buchd.2018.043
AMA ATAŞ BERKSOY E,ALPAY H,YILDIZ N,USER Y Kronik böbrek yetmezliği olan çocuklarda serum leptin konsantrasyonu. . 2018; 43 - 50. 10.5222/buchd.2018.043
Vancouver ATAŞ BERKSOY E,ALPAY H,YILDIZ N,USER Y Kronik böbrek yetmezliği olan çocuklarda serum leptin konsantrasyonu. . 2018; 43 - 50. 10.5222/buchd.2018.043
IEEE ATAŞ BERKSOY E,ALPAY H,YILDIZ N,USER Y "Kronik böbrek yetmezliği olan çocuklarda serum leptin konsantrasyonu." , ss.43 - 50, 2018. 10.5222/buchd.2018.043
ISNAD ATAŞ BERKSOY, Emel vd. "Kronik böbrek yetmezliği olan çocuklarda serum leptin konsantrasyonu". (2018), 43-50. https://doi.org/10.5222/buchd.2018.043
APA ATAŞ BERKSOY E, ALPAY H, YILDIZ N, USER Y (2018). Kronik böbrek yetmezliği olan çocuklarda serum leptin konsantrasyonu. İzmir Dr. Behçet Uz Çocuk Hastanesi Dergisi, 8(1), 43 - 50. 10.5222/buchd.2018.043
Chicago ATAŞ BERKSOY Emel,ALPAY HARİKA,YILDIZ Nurdan,USER Yasemen Kronik böbrek yetmezliği olan çocuklarda serum leptin konsantrasyonu. İzmir Dr. Behçet Uz Çocuk Hastanesi Dergisi 8, no.1 (2018): 43 - 50. 10.5222/buchd.2018.043
MLA ATAŞ BERKSOY Emel,ALPAY HARİKA,YILDIZ Nurdan,USER Yasemen Kronik böbrek yetmezliği olan çocuklarda serum leptin konsantrasyonu. İzmir Dr. Behçet Uz Çocuk Hastanesi Dergisi, vol.8, no.1, 2018, ss.43 - 50. 10.5222/buchd.2018.043
AMA ATAŞ BERKSOY E,ALPAY H,YILDIZ N,USER Y Kronik böbrek yetmezliği olan çocuklarda serum leptin konsantrasyonu. İzmir Dr. Behçet Uz Çocuk Hastanesi Dergisi. 2018; 8(1): 43 - 50. 10.5222/buchd.2018.043
Vancouver ATAŞ BERKSOY E,ALPAY H,YILDIZ N,USER Y Kronik böbrek yetmezliği olan çocuklarda serum leptin konsantrasyonu. İzmir Dr. Behçet Uz Çocuk Hastanesi Dergisi. 2018; 8(1): 43 - 50. 10.5222/buchd.2018.043
IEEE ATAŞ BERKSOY E,ALPAY H,YILDIZ N,USER Y "Kronik böbrek yetmezliği olan çocuklarda serum leptin konsantrasyonu." İzmir Dr. Behçet Uz Çocuk Hastanesi Dergisi, 8, ss.43 - 50, 2018. 10.5222/buchd.2018.043
ISNAD ATAŞ BERKSOY, Emel vd. "Kronik böbrek yetmezliği olan çocuklarda serum leptin konsantrasyonu". İzmir Dr. Behçet Uz Çocuk Hastanesi Dergisi 8/1 (2018), 43-50. https://doi.org/10.5222/buchd.2018.043