Assessment of Effects of Thyrotoxicosis on Gallstone Formation in Rabbits
Yıl: 2019 Cilt: 57 Sayı: 1 Sayfa Aralığı: 91 - 97 Metin Dili: İngilizce DOI: 10.4274/haseki.galenos.2019.4752 İndeks Tarihi: 04-11-2019
Assessment of Effects of Thyrotoxicosis on Gallstone Formation in Rabbits
Öz: Aim: The etiopathogenesis of gallstone formation is well known, butonly a few studies have investigated the effects of thyrotoxicosis ongallstone formation. In this study, we investigated the contribution ofthyrotoxicosis to gallstone formation in rabbits.Methods: Forty-four New Zealand rabbits were used. The rabbits weredivided into six groups, with each group receiving a different diet. Atthe end of seven weeks, all rabbits were sacrificed, blood was collectedfor analysis, and cholecystectomy was performed.Results: Serum levels of both free triiodothyronine (FT3) and thyroxine(FT4) were significantly higher in rabbits receiving thyroid hormone(p<0.001). The bile cholesterol saturation index (CSI) in the groupreceiving only thyroxine hormone was statistically higher than in thecontrol group (p=0.014). The rabbit group receiving a lithogenic dietand thyroxine hormone had significantly higher myeloperoxidaseactivities and fibrinogen levels, but lower bile acid levels comparedto controls (p<0.001). Focal leukocyte infiltration was noted in rabbitsreceiving thyroxine hormone, but no significant differences werefound in bile calcium levels between the groups (p>0.05).Conclusions: Thyrotoxicosis promotes an increase in gallstoneformation risk as a result of an increased bile CSI and gallbladdermucosal inflammation.
Anahtar Kelime: Konular:
Tavşanlarda Tirotoksikozun Safra Taşı Oluşumu Üzerine Etkilerinin Değerlendirilmesi
Öz: Amaç: Safra taşı oluşumun etiyopatogenezi bilinmesine rağmen, tirotoksikozun safra taşı oluşumu üzerinde etkisini araştıran çok az sayıda çalışma bulunmaktadır. Bu çalışmada tavşanlarda tirotoksikozun safra taşı üzerine etkileri araştırılmıştır. Yöntemler: Kırk dört adet Yeni Zelanda tipi tavşan kullanıldı. Tavşanlar, altı gruba bölündü ve her grup farklı diyetle beslendi. Çalışmanın 7. haftasında tavşanlar sakrifiye edilerek kan örnekleri alındı ve kolesistektomi yapıldı. Bulgular: Tiroksin hormonu verilen tavşanlarda serbest T3 ve T4 düzeyleri anlamlı şekilde yüksek bulundu (p<0,001). Kontrol grubu ile karşılaştırıldığında tiroksin hormonu verilen tavşanlarda safra kolesterol satürasyon indeksi (CSI) anlamlı şekilde yüksek bulundu (p=0,014). Litojenik diyet ile tiroksin hormonu alan tavşanlardaki miyeloperoksidaz ve fibrinojen serum düzeyleri kontrol grubundaki tavşanların düzeylere göre anlamlı şekilde yüsek bulunurken, safra asit düzeyleri istatistiksel olarak düşük bulundu (p<0,001). Tiroksin hormonu alan tavşanlarda safra kesesi mukozasında fokal infiltrason tespit edilirken, gruplar arasında safra serum kalsiyum düzeyleri arasında anlamlı bir fark bulunmadı (p>0,05). Sonuç: Tirotoksikoz, safra CSI’yı ve mukozal enflamasyonu arttırarak safra taşı oluşumu riskini arttırmaktadır.
Anahtar Kelime: Konular:
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
- Acalovschi M. Gallstones in patients with liver cirrhosis: incidence, etiology, clinical and therapeutical aspects. World J Gastroenterol 2014;20:7277-85.
- Wilkins T, Agabin E, Varghese J, Talukder A. Gallbladder Dysfunction: Cholecystitis, Choledocholithiasis, Cholangitis, and Biliary Dyskinesia. Prim Care 2017;44:575-97.
- Krawczyk M, Stokes CS, Lammert F. Genetics and treatment of bile duct stones: new approaches. Curr Opin Gastroenterol 2013;29:329-35.
- Koivusalo AI, Pakarinen MP, Sittiwet C, et al. Cholesterol, noncholesterol sterols and bile acids in paediatric gallstones. Dig Liver Dis 2010;42:61-6.
- Raghavendra CK, Srinivasan K. Influence of dietary tender cluster beans (Cyamopsis tetragonoloba) on biliary proteins, bile acid synthesis and cholesterol crystal growth in rat bile. Steroids 2015 ;94:21-30.
- Lambou-Gianoukos S, Heller SJ. Lithogenesis and bile metabolism. Surg Clin North Am 2008;88:1175-94.
- Stinton LM, Shaffer EA. Epidemiology of gallbladder disease: cholelithiasis and cancer. Gut Liver 2012;6:172-87.
- Xu G, Li Y, Jiang X, Chen H. CAV1 Prevents Gallbladder Cholesterol Crystallization by Regulating Biosynthesis and Transport of Bile Salts. J Cell Biochem 2016;117:2118-27.
- Pasternak A, Bugajska J, Szura M, et al. Biliary Polyunsaturated Fatty Acids and Telocytes in Gallstone Disease. Cell Transplant 2017;26:125-33.
- Lee EJ, Kim MH, Kim YR, Park JW, Park WJ. Proteasome inhibition protects against diet-induced gallstone formationthrough modulation of cholesterol and bile acid homeostasis. Int J Mol Med 2018;41:1715-23.
- Smelt AH. Triglycerides and gallstone formation. Clin Chim Acta 2010;411:1625-31.
- Wang Y, Yu X, Zhao QZ, et al. Thyroid dysfunction, either hyper or hypothyroidism, promotes gallstoneformation by different mechanisms. J Zhejiang Univ Sci B 2016;17:515-25.
- Bonde Y, Plosch T, Kuipers F, Angelin B, Rudling M. Stimulation of murine biliary cholesterol secretion by thyroid hormone is dependent on a functional ABCG5/G8 complex. Hepatology 2012;56:1828-37.
- Pedrelli M, Pramfalk C, Parini P. Thyroid hormones and thyroid hormone receptors: effects of thyromimetics on reverse cholesterol transport. World J Gastroenterol 2010;16:5958- 64.
- Ridker PM. From C-reactive protein to interleukin-6 to interleukin-1: moving upstream to identify novel targets for atheroprotection. Circ Res 2016;118:145-56.
- Di Ciaula A, Wang DQ, Portincasa P. An update on the pathogenesis of cholesterol gallstone disease. Curr Opin Gastroenterol 2017;34:71-80.
- Katsika D, Grjibovski A, Einarsson C, Lammert F, Lichtenstein P, Marschall HU. Genetic and environmental influences on symptomatic gallstone disease: a Swedish study of 43,141 twin pairs. Hepatology 2005;41:1138-43.
- Wang HH, Portincasa P, Wang DQ. Update on the Molecular Mechanisms Underlying the Effect of Cholecystokinin and Cholecystokinin-1 Receptor on the Formation of Cholesterol Gallstones. Curr Med Chem 2017;4:456-61.
- Portincasa P, Wang DQ. Intestinal absorption, hepatic synthesis, and biliary secretion of cholesterol: where are we for cholesterol gallstone formation? Hepatology 2012;55:1313-6.
- Di Ciaula A, Garruti G, Frühbeck G, et al. The Role Of Diet In The Pathogenesis Of Cholesterol Gallstones. Curr Med Chem 2017;11:124-8.
- Song Y, Xu C, Shao S, et al. Thyroid-stimulating hormone regulates hepatic bile acid homeostasis via SREBP-2/HNF-4α/ CYP7A1 axis. J Hepatol 2015;62:1171-9.
- Ockenga J, Valentini L, Schuetz T, et al. Plasma bile acids are associated with energy expenditure and thyroid function in humans. J Clin Endocrinol Metab 2012;97:535-42.
- Patti M-E, Houten SM, Bianco AC, et al. Serum bile acids are higher in humans with prior gastric bypass: potential contribution to improved glucose and lipid metabolism. Obesity 2009;17:1671-7.
- Hashimoto K, Mori M. Crosstalk of thyroid hormone receptor and liver X receptor in lipid metabolism and beyond. Endocr J 2011;58:921-30.
- Liu M, Liu C, Chen H, et al. Prevention of cholesterol gallstone disease by schaftoside in lithogenic diet-induced C57BL/6 mouse model. Eur J Pharmacol 2017;815:1-9.
- Venneman NG, van Erpecum KJ. Pathogenesis of gallstones. Gastroenterol. Clin. North Am 2009;39:171-83.
- Rege RV. Inflammatory cytokines alter human gallbladder epithelial cell absorption/secretion. J Gastrointest Surg 2000;4:185-92.
- Lavoie B, Nausch B, Zane EA, Leonard MR. Disruption of gallbladder smooth muscle function is an early feature in the development of cholesterol gallstone disease. Neurogastroenterol Motil 2012;24:313-24.
- Cariati A. Gallstone Classification in Western Countries. Indian J Surg 2015;77:376-80.
- Yu JK, Pan H, Huang SM, et al. Calcium content of different compositions of gallstones and pathogenesis of calcium carbonate gallstones. Asian J Surg 2013;36:26-35.
- Chen K, Xie Y, Zhao L, Mo Z. Hyperthyroidism-associated hypercalcemic crisis: A case report and review of the literature. Medicine (Baltimore) 2017;96:6017.
- Bigi A, Boanini E. Calcium Phosphates as Delivery Systems for Bisphosphonates. J Funct Biomater 2018;9:1-18.
- Boanini E, Torricelli P, Gazzano M, Fini M, Bigi A. The effect of alendronate doped calcium phosphates on bone cells activity. Bone 2012;51:944-52.
| APA | GÜNAY Y, Tutuncu T, ÖCALAN T, Bilgihan A, KORKMAZ G, KAMA N (2019). Assessment of Effects of Thyrotoxicosis on Gallstone Formation in Rabbits. , 91 - 97. 10.4274/haseki.galenos.2019.4752 |
| Chicago | GÜNAY Yusuf,Tutuncu Tanju,ÖCALAN Tuba,Bilgihan Ayse,KORKMAZ Gülcan,KAMA Nuri Aydın Assessment of Effects of Thyrotoxicosis on Gallstone Formation in Rabbits. (2019): 91 - 97. 10.4274/haseki.galenos.2019.4752 |
| MLA | GÜNAY Yusuf,Tutuncu Tanju,ÖCALAN Tuba,Bilgihan Ayse,KORKMAZ Gülcan,KAMA Nuri Aydın Assessment of Effects of Thyrotoxicosis on Gallstone Formation in Rabbits. , 2019, ss.91 - 97. 10.4274/haseki.galenos.2019.4752 |
| AMA | GÜNAY Y,Tutuncu T,ÖCALAN T,Bilgihan A,KORKMAZ G,KAMA N Assessment of Effects of Thyrotoxicosis on Gallstone Formation in Rabbits. . 2019; 91 - 97. 10.4274/haseki.galenos.2019.4752 |
| Vancouver | GÜNAY Y,Tutuncu T,ÖCALAN T,Bilgihan A,KORKMAZ G,KAMA N Assessment of Effects of Thyrotoxicosis on Gallstone Formation in Rabbits. . 2019; 91 - 97. 10.4274/haseki.galenos.2019.4752 |
| IEEE | GÜNAY Y,Tutuncu T,ÖCALAN T,Bilgihan A,KORKMAZ G,KAMA N "Assessment of Effects of Thyrotoxicosis on Gallstone Formation in Rabbits." , ss.91 - 97, 2019. 10.4274/haseki.galenos.2019.4752 |
| ISNAD | GÜNAY, Yusuf vd. "Assessment of Effects of Thyrotoxicosis on Gallstone Formation in Rabbits". (2019), 91-97. https://doi.org/10.4274/haseki.galenos.2019.4752 |
| APA | GÜNAY Y, Tutuncu T, ÖCALAN T, Bilgihan A, KORKMAZ G, KAMA N (2019). Assessment of Effects of Thyrotoxicosis on Gallstone Formation in Rabbits. Haseki Tıp Bülteni, 57(1), 91 - 97. 10.4274/haseki.galenos.2019.4752 |
| Chicago | GÜNAY Yusuf,Tutuncu Tanju,ÖCALAN Tuba,Bilgihan Ayse,KORKMAZ Gülcan,KAMA Nuri Aydın Assessment of Effects of Thyrotoxicosis on Gallstone Formation in Rabbits. Haseki Tıp Bülteni 57, no.1 (2019): 91 - 97. 10.4274/haseki.galenos.2019.4752 |
| MLA | GÜNAY Yusuf,Tutuncu Tanju,ÖCALAN Tuba,Bilgihan Ayse,KORKMAZ Gülcan,KAMA Nuri Aydın Assessment of Effects of Thyrotoxicosis on Gallstone Formation in Rabbits. Haseki Tıp Bülteni, vol.57, no.1, 2019, ss.91 - 97. 10.4274/haseki.galenos.2019.4752 |
| AMA | GÜNAY Y,Tutuncu T,ÖCALAN T,Bilgihan A,KORKMAZ G,KAMA N Assessment of Effects of Thyrotoxicosis on Gallstone Formation in Rabbits. Haseki Tıp Bülteni. 2019; 57(1): 91 - 97. 10.4274/haseki.galenos.2019.4752 |
| Vancouver | GÜNAY Y,Tutuncu T,ÖCALAN T,Bilgihan A,KORKMAZ G,KAMA N Assessment of Effects of Thyrotoxicosis on Gallstone Formation in Rabbits. Haseki Tıp Bülteni. 2019; 57(1): 91 - 97. 10.4274/haseki.galenos.2019.4752 |
| IEEE | GÜNAY Y,Tutuncu T,ÖCALAN T,Bilgihan A,KORKMAZ G,KAMA N "Assessment of Effects of Thyrotoxicosis on Gallstone Formation in Rabbits." Haseki Tıp Bülteni, 57, ss.91 - 97, 2019. 10.4274/haseki.galenos.2019.4752 |
| ISNAD | GÜNAY, Yusuf vd. "Assessment of Effects of Thyrotoxicosis on Gallstone Formation in Rabbits". Haseki Tıp Bülteni 57/1 (2019), 91-97. https://doi.org/10.4274/haseki.galenos.2019.4752 |
