Biochemical markers decrease and increase disproportionally in A1 pulley tissue of type 2 diabetic trigger finger patients
Yıl: 2019 Cilt: 30 Sayı: 2 Sayfa Aralığı: 117 - 123 Metin Dili: İngilizce DOI: 10.5606/ehc.2019.66112 İndeks Tarihi: 25-11-2019
Biochemical markers decrease and increase disproportionally in A1 pulley tissue of type 2 diabetic trigger finger patients
Öz: Objectives: This study aims to detect the levels of some biochemical markers in A1 pulley tissue of type 2 diabetic trigger finger patients to enlighten the mechanisms leading to cellular complications. Patients and methods: The study included 35 trigger finger patients (5 males, 30 females; mean age 53.9±9.15 years; range, 37 to 71 years). We measured total thiol (total-SH) levels to determine the status of the non-enzymatic antioxidant defense system and advanced oxidation protein product (AOPP) levels to determine levels of oxidative protein modification in pulley tissues of trigger finger patients with or without diabetes. Extracellular matrix degradation was assessed by measuring levels of sialic acid (SA) in the pulley tissue. Results: Total-SH values for the groups with and without diabetes were 22.7±1.6 vs. 38.9±5.2 nmol/mg protein, respectively, while AOPP values were 472.5±131.6 vs.175.6±9.9 mmol/g protein, respectively. The SA levels of diabetic and nondiabetic patients were 0.4±0.0 vs. 0.63±0.1 nmol/mg protein, respectively. Conclusion: Our results revealed that tissue SA levels and tissue SH levels decreased and AOPP levels increased disproportionally in the A1 pulley tissue of diabetic patients, which may indicate the role of oxidative protein damage and extracellular matrix changes in diabetic trigger finger etiology.
Anahtar Kelime: Konular:
Tip 2 diyabetik tetik parmak hastalarında A1 pulley dokusunda biyokimyasal belirteçler orantısız olarak azalır ve artar
Öz: Amaç: Bu çalışmada hücresel komplikasyonlara yol açan mekanizmaları aydınlatmak için tip 2 diyabetik tetik parmak hastalarında A1 pulley dokusunda bazı biyokimyasal belirteçlerin düzeyleri saptandı. Hastalar ve yöntemler: Çalışmaya 35 tetik parmak hastası (5 erkek, 30 kadın; ort. yaş 53.9±9.15 yıl; dağılım, 37-71 yıl) dahil edildi. Enzimatik olmayan antioksidan savunma sisteminin durumunu belirlemek için total tiyol (total-SH) düzeyleri, oksidatif protein modifikasyon düzeylerini belirlemek için gelişmiş oksidasyon protein ürünü (AOPP) düzeyleri diyabetli ve diyabetli olmayan tetik parmak hastalarının pulley dokularında ölçüldü. Hücre dışı matriks bozulması pulley dokusundaki sialik asit (SA) düzeylerinin ölçülmesiyle değerlendirildi. Bulgular: Diyabetli ve diyabetli olmayan gruplar için total-SH değerleri sırasıyla 22.7±1.6’ya karşı 38.9±5.2 nmol/mg protein iken AOPP değerleri sırasıyla 472.5±131.6’ya karşı 175.6±9.9 mmol/g protein idi. Diyabetik ve diyabetik olmayan hastaların SA düzeyleri sırasıyla 0.4±0.0’e karşı 0.6±0.1 nmol/mg protein idi. Sonuç: Bulgularımız diyabetik hastaların A1 pulley dokularında doku SA düzeylerinin ve doku SH düzeylerinin azaldığını ve AOPP düzeylerinin orantısız olarak arttığını ortaya koyarak diyabetik tetik parmak etyolojisinde oksidatif protein hasarı ve hücre dışı matriks değişikliklerinin rolüne işaret etmektedir
Anahtar Kelime: Konular:
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | ALP N, Akdag G, KARDUZ G, vardar k, Aksu U (2019). Biochemical markers decrease and increase disproportionally in A1 pulley tissue of type 2 diabetic trigger finger patients. , 117 - 123. 10.5606/ehc.2019.66112 |
| Chicago | ALP Nazmi Bulent,Akdag Gokhan,KARDUZ Gülsüm,vardar kubra,Aksu Ugur Biochemical markers decrease and increase disproportionally in A1 pulley tissue of type 2 diabetic trigger finger patients. (2019): 117 - 123. 10.5606/ehc.2019.66112 |
| MLA | ALP Nazmi Bulent,Akdag Gokhan,KARDUZ Gülsüm,vardar kubra,Aksu Ugur Biochemical markers decrease and increase disproportionally in A1 pulley tissue of type 2 diabetic trigger finger patients. , 2019, ss.117 - 123. 10.5606/ehc.2019.66112 |
| AMA | ALP N,Akdag G,KARDUZ G,vardar k,Aksu U Biochemical markers decrease and increase disproportionally in A1 pulley tissue of type 2 diabetic trigger finger patients. . 2019; 117 - 123. 10.5606/ehc.2019.66112 |
| Vancouver | ALP N,Akdag G,KARDUZ G,vardar k,Aksu U Biochemical markers decrease and increase disproportionally in A1 pulley tissue of type 2 diabetic trigger finger patients. . 2019; 117 - 123. 10.5606/ehc.2019.66112 |
| IEEE | ALP N,Akdag G,KARDUZ G,vardar k,Aksu U "Biochemical markers decrease and increase disproportionally in A1 pulley tissue of type 2 diabetic trigger finger patients." , ss.117 - 123, 2019. 10.5606/ehc.2019.66112 |
| ISNAD | ALP, Nazmi Bulent vd. "Biochemical markers decrease and increase disproportionally in A1 pulley tissue of type 2 diabetic trigger finger patients". (2019), 117-123. https://doi.org/10.5606/ehc.2019.66112 |
| APA | ALP N, Akdag G, KARDUZ G, vardar k, Aksu U (2019). Biochemical markers decrease and increase disproportionally in A1 pulley tissue of type 2 diabetic trigger finger patients. Eklem Hastalıkları ve Cerrahisi Dergisi (Eski Adı: Artroplasti Artroskopik Cerrahi Derg.), 30(2), 117 - 123. 10.5606/ehc.2019.66112 |
| Chicago | ALP Nazmi Bulent,Akdag Gokhan,KARDUZ Gülsüm,vardar kubra,Aksu Ugur Biochemical markers decrease and increase disproportionally in A1 pulley tissue of type 2 diabetic trigger finger patients. Eklem Hastalıkları ve Cerrahisi Dergisi (Eski Adı: Artroplasti Artroskopik Cerrahi Derg.) 30, no.2 (2019): 117 - 123. 10.5606/ehc.2019.66112 |
| MLA | ALP Nazmi Bulent,Akdag Gokhan,KARDUZ Gülsüm,vardar kubra,Aksu Ugur Biochemical markers decrease and increase disproportionally in A1 pulley tissue of type 2 diabetic trigger finger patients. Eklem Hastalıkları ve Cerrahisi Dergisi (Eski Adı: Artroplasti Artroskopik Cerrahi Derg.), vol.30, no.2, 2019, ss.117 - 123. 10.5606/ehc.2019.66112 |
| AMA | ALP N,Akdag G,KARDUZ G,vardar k,Aksu U Biochemical markers decrease and increase disproportionally in A1 pulley tissue of type 2 diabetic trigger finger patients. Eklem Hastalıkları ve Cerrahisi Dergisi (Eski Adı: Artroplasti Artroskopik Cerrahi Derg.). 2019; 30(2): 117 - 123. 10.5606/ehc.2019.66112 |
| Vancouver | ALP N,Akdag G,KARDUZ G,vardar k,Aksu U Biochemical markers decrease and increase disproportionally in A1 pulley tissue of type 2 diabetic trigger finger patients. Eklem Hastalıkları ve Cerrahisi Dergisi (Eski Adı: Artroplasti Artroskopik Cerrahi Derg.). 2019; 30(2): 117 - 123. 10.5606/ehc.2019.66112 |
| IEEE | ALP N,Akdag G,KARDUZ G,vardar k,Aksu U "Biochemical markers decrease and increase disproportionally in A1 pulley tissue of type 2 diabetic trigger finger patients." Eklem Hastalıkları ve Cerrahisi Dergisi (Eski Adı: Artroplasti Artroskopik Cerrahi Derg.), 30, ss.117 - 123, 2019. 10.5606/ehc.2019.66112 |
| ISNAD | ALP, Nazmi Bulent vd. "Biochemical markers decrease and increase disproportionally in A1 pulley tissue of type 2 diabetic trigger finger patients". Eklem Hastalıkları ve Cerrahisi Dergisi (Eski Adı: Artroplasti Artroskopik Cerrahi Derg.) 30/2 (2019), 117-123. https://doi.org/10.5606/ehc.2019.66112 |
