Yıl: 2019 Cilt: 10 Sayı: 3 Sayfa Aralığı: 473 - 477 Metin Dili: Türkçe İndeks Tarihi: 25-11-2019

Nüks Rektum Kanserinde İntraoperatif Radyoterapi

Öz:
Giriş: Lokal ileri ve nüks rektum kanserinde multimodal tedavi seçeneklerden biri olan intraoperatif radyoterapi (İORT), lokalkontrolü sağlamak için tercih edilebilir. Bu çalışmada nüks rektum kanseri nedeniyle radikal cerrahi ve intraoperatif radyoterapiuyguladığımız hastalar üzerindeki deneyimimizi sunmayı amaçladık.Metod: Acıbadem Mehmet Ali Aydınlar Üniversitesi Tıp Fakültesi, Maslak Hastanesi’nde Kasım 2012 ve Aralık 2016 tarihleri arasında nüks rektum kanseri nedeniyle radikal cerrahi ve İORT uygulanan hastaların klinik özellikleri ve ameliyat sonrası takiplerideğerlendirildi.Bulgular: Çalışmamıza nüks rektum kanseri olan 8 hasta (4 kadın) dahil edildi. Tüm hastalarda nüks adenokarsinom mevcuttu.Hastaların ortanca yaş değeri 54.5 (33-67) ve vücut kitle indeksi 24.3 (19.6-32.5) kg/m2 idi. Rektum kanseri için yapılan ilkameliyatların tümü sfinkter koruyucu rezeksiyondu. Nüks tümör nedeniyle 4 hastaya aşağı anterior rezeksiyon, 2 hastaya abdominoperineal rezeksiyon, 2 hastaya da pelvisten kitle çıkarılması işlemi uygulandı. 5 hastaya R0, 2 hastaya R1 ve 1 hastaya R2rezeksiyon yapıldı. Ameliyat sonrası erken dönem takiplerinde 2 hastada cerrahi yara enfeksiyonu gelişti. Ortanca hastanedekalış süresi 8 (4-10) gündü. Ortanca 35.5 (7-52) aylık takip süresince 4 hasta hastalıksız takip edilmektedir. İki hastada pelviknüks gelişti. İki hasta eksitus oldu.Sonuç: Nüks rektum kanserinde intraoperatif radyoterapi, toksisite riskini azaltarak yüksek doz radyoterapi uygulayabilmemizeolanak sağlayan ve bu yolla cerrahinin lokal kontrol üzerindeki etkinliğini artıran bir yöntemdir.
Anahtar Kelime:

Konular: Tıbbi Araştırmalar Deneysel Onkoloji Radyoloji, Nükleer Tıp, Tıbbi Görüntüleme Cerrahi

INTRAOPERATIVE RADIATION THERAPY FOR RECURRENT RECTAL CANCER

Öz:
Introduction: As one of the multimodal treatment options available in locally advanced or recurrent rectal cancer, intraoperative radiotherapy (IORT) may be a preferred option to achieve local control. In this study, we aim to report on our experience with those recurrent rectal cancer cases which were treated with radical surgery and intraoperative radiotherapy. Methods: Cases treated with radical surgery and IORT for recurrent rectal cancer between November 2012 and December 2016 at Acibadem Mehmet Ali Aydinlar University Medical Faculty Hospital, Maslak, Istanbul, were included in this study. Results: 8 patients (4 male, 4 female ) with recurrent rectal cancer were included in this study. All the patients had recurrent adenocarcinoma. The median age was 54.5 (range 33-67) and median BMI was 34.3 (range 19.6-32.5) kg/m2 . In all cases, the previous surgery undertaken was sphincter-preserving resection. For recurrent tumors, low anterior resection was performed on 4 patients, abdominoperineal resection was performed on 2 patients and pelvic exenteration was performed on 2 patients. R0 resection was observed in 5, R1 in 2, and R2 in 1 patient. At short-term follow-up, infection had developed at the operative site in 2 patients. The median hospital stay was 8 (4-10) days. During the median follow-up period of 36 (7-52) months, 4 patients were observed to be disease-free, 2 patients had pelvic recurrence and 2 patients died. Conclusion: IORT increases the effectiveness of surgery for local control in recurrent rectal cancer and additionally decreases the risk of toxicity, thus enabling the application of high dose radiotherapy.
Anahtar Kelime:

Konular: Tıbbi Araştırmalar Deneysel Onkoloji Radyoloji, Nükleer Tıp, Tıbbi Görüntüleme Cerrahi
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA bilgin i, Aytac E, ERENLER BAYRAKTAR İ, Şahin A, Atalar B, BEŞE N, ÖZYAR E, Baca B, HAMZAOĞLU İ, KARAHASANOĞLU T (2019). Nüks Rektum Kanserinde İntraoperatif Radyoterapi. , 473 - 477.
Chicago bilgin ismail ahmet,Aytac Erman,ERENLER BAYRAKTAR İlknur,Şahin Ahmet Bilgehan,Atalar Banu,BEŞE Nuran,ÖZYAR Enis,Baca Bilgi,HAMZAOĞLU İSMAİL HAKKI,KARAHASANOĞLU Tayfun Nüks Rektum Kanserinde İntraoperatif Radyoterapi. (2019): 473 - 477.
MLA bilgin ismail ahmet,Aytac Erman,ERENLER BAYRAKTAR İlknur,Şahin Ahmet Bilgehan,Atalar Banu,BEŞE Nuran,ÖZYAR Enis,Baca Bilgi,HAMZAOĞLU İSMAİL HAKKI,KARAHASANOĞLU Tayfun Nüks Rektum Kanserinde İntraoperatif Radyoterapi. , 2019, ss.473 - 477.
AMA bilgin i,Aytac E,ERENLER BAYRAKTAR İ,Şahin A,Atalar B,BEŞE N,ÖZYAR E,Baca B,HAMZAOĞLU İ,KARAHASANOĞLU T Nüks Rektum Kanserinde İntraoperatif Radyoterapi. . 2019; 473 - 477.
Vancouver bilgin i,Aytac E,ERENLER BAYRAKTAR İ,Şahin A,Atalar B,BEŞE N,ÖZYAR E,Baca B,HAMZAOĞLU İ,KARAHASANOĞLU T Nüks Rektum Kanserinde İntraoperatif Radyoterapi. . 2019; 473 - 477.
IEEE bilgin i,Aytac E,ERENLER BAYRAKTAR İ,Şahin A,Atalar B,BEŞE N,ÖZYAR E,Baca B,HAMZAOĞLU İ,KARAHASANOĞLU T "Nüks Rektum Kanserinde İntraoperatif Radyoterapi." , ss.473 - 477, 2019.
ISNAD bilgin, ismail ahmet vd. "Nüks Rektum Kanserinde İntraoperatif Radyoterapi". (2019), 473-477.
APA bilgin i, Aytac E, ERENLER BAYRAKTAR İ, Şahin A, Atalar B, BEŞE N, ÖZYAR E, Baca B, HAMZAOĞLU İ, KARAHASANOĞLU T (2019). Nüks Rektum Kanserinde İntraoperatif Radyoterapi. Acıbadem Üniversitesi Sağlık Bilimleri Dergisi, 10(3), 473 - 477.
Chicago bilgin ismail ahmet,Aytac Erman,ERENLER BAYRAKTAR İlknur,Şahin Ahmet Bilgehan,Atalar Banu,BEŞE Nuran,ÖZYAR Enis,Baca Bilgi,HAMZAOĞLU İSMAİL HAKKI,KARAHASANOĞLU Tayfun Nüks Rektum Kanserinde İntraoperatif Radyoterapi. Acıbadem Üniversitesi Sağlık Bilimleri Dergisi 10, no.3 (2019): 473 - 477.
MLA bilgin ismail ahmet,Aytac Erman,ERENLER BAYRAKTAR İlknur,Şahin Ahmet Bilgehan,Atalar Banu,BEŞE Nuran,ÖZYAR Enis,Baca Bilgi,HAMZAOĞLU İSMAİL HAKKI,KARAHASANOĞLU Tayfun Nüks Rektum Kanserinde İntraoperatif Radyoterapi. Acıbadem Üniversitesi Sağlık Bilimleri Dergisi, vol.10, no.3, 2019, ss.473 - 477.
AMA bilgin i,Aytac E,ERENLER BAYRAKTAR İ,Şahin A,Atalar B,BEŞE N,ÖZYAR E,Baca B,HAMZAOĞLU İ,KARAHASANOĞLU T Nüks Rektum Kanserinde İntraoperatif Radyoterapi. Acıbadem Üniversitesi Sağlık Bilimleri Dergisi. 2019; 10(3): 473 - 477.
Vancouver bilgin i,Aytac E,ERENLER BAYRAKTAR İ,Şahin A,Atalar B,BEŞE N,ÖZYAR E,Baca B,HAMZAOĞLU İ,KARAHASANOĞLU T Nüks Rektum Kanserinde İntraoperatif Radyoterapi. Acıbadem Üniversitesi Sağlık Bilimleri Dergisi. 2019; 10(3): 473 - 477.
IEEE bilgin i,Aytac E,ERENLER BAYRAKTAR İ,Şahin A,Atalar B,BEŞE N,ÖZYAR E,Baca B,HAMZAOĞLU İ,KARAHASANOĞLU T "Nüks Rektum Kanserinde İntraoperatif Radyoterapi." Acıbadem Üniversitesi Sağlık Bilimleri Dergisi, 10, ss.473 - 477, 2019.
ISNAD bilgin, ismail ahmet vd. "Nüks Rektum Kanserinde İntraoperatif Radyoterapi". Acıbadem Üniversitesi Sağlık Bilimleri Dergisi 10/3 (2019), 473-477.