The primary scope of this study is to examine the variations of key mechanical designperformance features and mechanical characterization of Bi2.1Sr2.0-xTixCa1.1Cu2.0Oysuperconductors via Vickers hardness tests performed at different test loads between 0.245 Nand 2.940 N. The materials are prepared within the molar ratios of 0≤x≤0.10 by using theceramic method in the atmospheric air. The measurement findings obtained indicate that theincrement of Sr/Ti partial substitution level regresses remarkably the key design mechanicalperformances namely mechanical strength, stability, stiffness, critical stress, toughness, flexuralstrengths and mechanical durability. This means that the existence of Ti impurity matrix leadsto the enhancement in the problematic defects, crack initiation sites and stress raisers based onthe crack-producing omnipresent flaws. Accordingly, the propagation of the problematicdefects accelerates considerably at lower indentation test loads applied, and the problematicdefects locate easily in their critical propagation speed. All in all, the crystal defects are out ofcontrol, and the Sr/Ti partial substituted Bi2.1Sr2.0-xTixCa1.1Cu2.0Oy superconductiors are mucheasier broken. Additionally, it is noted that every material produced show the typicalindentation size effect but in diminish trend with enhancing Sr/Ti partial replacement level. Theload-dependent mechanical parameters such as Young’s modulus, yield strength, fracturetoughness, brittleness index and elastic stiffness coefficients are also discussed in the text.