Microwave-Assisted Synthesis and Biological Evaluation of Some Coumarin Hydrazides

Fatih YILMAZ, (Recep Tayyip Erdoğan Üniversitesi)
Özlem FAİZ (Recep Tayyip Erdoğan Üniversitesi)
Journal of the Turkish Chemical Society, Section A: Chemistry
3 0
Yıl: 2018 Cilt: 5 Sayı: 2 Sayfa Aralığı: 551 - 568 Metin Dili: İngilizce DOI: 10.18596/jotcsa.390928 İndeks Tarihi: 22-02-2020

Microwave-Assisted Synthesis and Biological Evaluation of Some Coumarin Hydrazides

Öz:
In this work, 15 different coumarin hydrazides were successfully synthesized andscreened for their antioxidant and antilipase activities. To do this, firstly, salicylaldehydederivatives and Meldrum's Acid were reacted in absolute ethanol with catalytic amount ofpyridine to obtain coumarin-3-carboxylic acid derivatives (1a-e). Then, these compounds weretreated with 1H-benzotriazole in dichloromethane by using thionyl chloride to synthesizebenzotriazole derivatives (2a-e). Then, compounds 2a-e were reacted with three commercialhydrazides (nicotinic hydrazide, benzhydrazide,and phenyl acetichydrazide) in ethanol by usingmicrowave irradiation and conventional heating procedures to obtain final products (3-5a-e).Finally, these compounds were tested for their anti-oxidant and anti-lipase activities. Thestructure of newly synthesized compounds was identified by IR, 1H NMR, 13C NMR, and elementalanalysis data.
Anahtar Kelime:

Konular: Kimya, Analitik Termodinamik Spektroskopi Kimya, Uygulamalı Kimya, Organik Kimya, Tıbbi Fizikokimya Kimya, İnorganik ve Nükleer
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA Yılmaz F, Faiz Ö (2018). Microwave-Assisted Synthesis and Biological Evaluation of Some Coumarin Hydrazides. , 551 - 568. 10.18596/jotcsa.390928
Chicago Yılmaz Fatih,Faiz Özlem Microwave-Assisted Synthesis and Biological Evaluation of Some Coumarin Hydrazides. (2018): 551 - 568. 10.18596/jotcsa.390928
MLA Yılmaz Fatih,Faiz Özlem Microwave-Assisted Synthesis and Biological Evaluation of Some Coumarin Hydrazides. , 2018, ss.551 - 568. 10.18596/jotcsa.390928
AMA Yılmaz F,Faiz Ö Microwave-Assisted Synthesis and Biological Evaluation of Some Coumarin Hydrazides. . 2018; 551 - 568. 10.18596/jotcsa.390928
Vancouver Yılmaz F,Faiz Ö Microwave-Assisted Synthesis and Biological Evaluation of Some Coumarin Hydrazides. . 2018; 551 - 568. 10.18596/jotcsa.390928
IEEE Yılmaz F,Faiz Ö "Microwave-Assisted Synthesis and Biological Evaluation of Some Coumarin Hydrazides." , ss.551 - 568, 2018. 10.18596/jotcsa.390928
ISNAD Yılmaz, Fatih - Faiz, Özlem. "Microwave-Assisted Synthesis and Biological Evaluation of Some Coumarin Hydrazides". (2018), 551-568. https://doi.org/10.18596/jotcsa.390928
APA Yılmaz F, Faiz Ö (2018). Microwave-Assisted Synthesis and Biological Evaluation of Some Coumarin Hydrazides. Journal of the Turkish Chemical Society, Section A: Chemistry, 5(2), 551 - 568. 10.18596/jotcsa.390928
Chicago Yılmaz Fatih,Faiz Özlem Microwave-Assisted Synthesis and Biological Evaluation of Some Coumarin Hydrazides. Journal of the Turkish Chemical Society, Section A: Chemistry 5, no.2 (2018): 551 - 568. 10.18596/jotcsa.390928
MLA Yılmaz Fatih,Faiz Özlem Microwave-Assisted Synthesis and Biological Evaluation of Some Coumarin Hydrazides. Journal of the Turkish Chemical Society, Section A: Chemistry, vol.5, no.2, 2018, ss.551 - 568. 10.18596/jotcsa.390928
AMA Yılmaz F,Faiz Ö Microwave-Assisted Synthesis and Biological Evaluation of Some Coumarin Hydrazides. Journal of the Turkish Chemical Society, Section A: Chemistry. 2018; 5(2): 551 - 568. 10.18596/jotcsa.390928
Vancouver Yılmaz F,Faiz Ö Microwave-Assisted Synthesis and Biological Evaluation of Some Coumarin Hydrazides. Journal of the Turkish Chemical Society, Section A: Chemistry. 2018; 5(2): 551 - 568. 10.18596/jotcsa.390928
IEEE Yılmaz F,Faiz Ö "Microwave-Assisted Synthesis and Biological Evaluation of Some Coumarin Hydrazides." Journal of the Turkish Chemical Society, Section A: Chemistry, 5, ss.551 - 568, 2018. 10.18596/jotcsa.390928
ISNAD Yılmaz, Fatih - Faiz, Özlem. "Microwave-Assisted Synthesis and Biological Evaluation of Some Coumarin Hydrazides". Journal of the Turkish Chemical Society, Section A: Chemistry 5/2 (2018), 551-568. https://doi.org/10.18596/jotcsa.390928
Sayfa Oluşturulma Tarihi
23-04-2024 10:30

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