Yıl: 2018 Cilt: 27 Sayı: 3 Sayfa Aralığı: 249 - 253 Metin Dili: İngilizce İndeks Tarihi: 25-02-2020

Rapidly Progressive Glomerulonephritis: A Single-Center Experience

Öz:
OBJECTIVE: Rapidly progressive glomerulonephritis is associated with rapid deterioration ofkidney function. We aimed to evaluate patients followed-up with the diagnosis of rapidly progressiveglomerulonephritis.MATERIAL and METHODS: This retrospective study included 28 patients who were compared forremission status and baseline serum creatinine levels.RESULTS: We evaluated 20 male and 8 female patients with a mean age of 46.68 ±15.94 years.Patients with higher baseline serum creatinine had significantly lower hemoglobin (p=0.01), plateletcounts (p=0.01) and calculated e- GFR at last hospital visit (p=0.03) compared to patients with lowerbaseline serum creatinine. At discharge, the number of dialysis-dependent patients was significantlyhigher in the patients with higher baseline serum creatinine than the patients with lower baseline serumcreatinine (p=0.01). Patients who had achieved remission had significantly lower percentage of cellularcrescents (p= 0.009) and sclerotic glomeruli (p= 0.04) than patients who did not achieve remission.Dead patients were more likely to have a lymphocyte count of < 1000 cells/mm3 (p=0.009).CONCLUSION: Patients with high baseline serum creatinine levels were more likely to have lowerhemoglobin levels and platelet counts. High baseline serum creatinine level and high percentage ofcellular crescents and sclerotic glomeruli were related to worse renal prognosis. Patients with lowerlymphocyte counts had higher mortality rates.
Anahtar Kelime:

Konular: Cerrahi

Hızlı İlerleyen Glomerülonefritler: Tek Merkez Deneyimi

Öz:
AMAÇ: Hızlı ilerleyen glomerülonefritler böbrek fonksiyonlarının hızlı kaybı ile ilişkilidir. Hızlı ilerleyen glomerülonefrit tanısıyla takip edilen hastaları değerlendirmeyi amaçladık. GEREÇ ve YÖNTEMLER: Bu retrospektif çalışma 28 hastayı kapsadı. Hastalar remisyon durumları ve başvuru bazal serum kreatinin seviyeleri açısından karşılaştırıldı. BULGULAR: Ortalama yaşları 46,68±15,94 yıl olan yirmi erkek, sekiz kadın hasta değerlendirildi. Bazal serum kreatinin seviyesi yüksek olan hastaların hemoglobin seviyeleri (p=0,01) ve platelet sayıları (p=0,01) bazal serum kreatinin seviyesi düşük olan hastalara göre anlamlı olarak daha düşüktü. Bazal serum kreatinin seviyesi yüksek olan hastaların son hastane başvurusunda hesaplanan e- GFR değerleri, bazal serum kreatinin seviyesi düşük olan hastalara göre anlamlı olarak daha düşüktü (p=0,03). Taburculuk esnasında diyaliz bağımlı hasta sayısı, bazal serum kreatinin seviyesi yüksek olan hastalarda, bazal serum kreatinin düşük olan hastalara göre anlamlı olarak daha yüksekti (p=0,01). Remisyon sağlanan hastalarda remisyon sağlanamayanlara göre ortalama sellüler kresent yüzdesi (p=0,009) ve sklerotik glomerül yüzdesi (p=0,04) anlamlı olarak daha düşüktü. Ölen hastaların lenfosit sayılarının 1000 hücre/mm3 altında olma ihtimali daha yüksekti (p=0,009). SONUÇ: Serimizde bazal serum kreatinin seviyesi yüksek olan hastalarda hemoglobin seviyesi, platelet sayısı düşük saptandı. Yüksek bazal serum kreatinin seviyesi, yüksek sellüler kresent ve sklerotik glomerül yüzdelerinin kötü renal prognoz ile ilişkili olduğu saptandı. Ölen hastaların daha düşük lenfosit sayısına sahip oldukları gösterildi.
Anahtar Kelime:

Konular: Cerrahi
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA Can Ö, Gümrükçü G, AKER F, BAŞ S, GÜREN A, Bilek G, APAYDIN S, MANGA ŞAHİN G (2018). Rapidly Progressive Glomerulonephritis: A Single-Center Experience. , 249 - 253.
Chicago Can Özgür,Gümrükçü Gülistan,AKER Fügen Vardar,BAŞ SÜLEYMAN,GÜREN Ali Kaan,Bilek Gunal,APAYDIN SUHEYLA,MANGA ŞAHİN Gülizar Rapidly Progressive Glomerulonephritis: A Single-Center Experience. (2018): 249 - 253.
MLA Can Özgür,Gümrükçü Gülistan,AKER Fügen Vardar,BAŞ SÜLEYMAN,GÜREN Ali Kaan,Bilek Gunal,APAYDIN SUHEYLA,MANGA ŞAHİN Gülizar Rapidly Progressive Glomerulonephritis: A Single-Center Experience. , 2018, ss.249 - 253.
AMA Can Ö,Gümrükçü G,AKER F,BAŞ S,GÜREN A,Bilek G,APAYDIN S,MANGA ŞAHİN G Rapidly Progressive Glomerulonephritis: A Single-Center Experience. . 2018; 249 - 253.
Vancouver Can Ö,Gümrükçü G,AKER F,BAŞ S,GÜREN A,Bilek G,APAYDIN S,MANGA ŞAHİN G Rapidly Progressive Glomerulonephritis: A Single-Center Experience. . 2018; 249 - 253.
IEEE Can Ö,Gümrükçü G,AKER F,BAŞ S,GÜREN A,Bilek G,APAYDIN S,MANGA ŞAHİN G "Rapidly Progressive Glomerulonephritis: A Single-Center Experience." , ss.249 - 253, 2018.
ISNAD Can, Özgür vd. "Rapidly Progressive Glomerulonephritis: A Single-Center Experience". (2018), 249-253.
APA Can Ö, Gümrükçü G, AKER F, BAŞ S, GÜREN A, Bilek G, APAYDIN S, MANGA ŞAHİN G (2018). Rapidly Progressive Glomerulonephritis: A Single-Center Experience. Türk Nefroloji Diyaliz ve Transplantasyon Dergisi, 27(3), 249 - 253.
Chicago Can Özgür,Gümrükçü Gülistan,AKER Fügen Vardar,BAŞ SÜLEYMAN,GÜREN Ali Kaan,Bilek Gunal,APAYDIN SUHEYLA,MANGA ŞAHİN Gülizar Rapidly Progressive Glomerulonephritis: A Single-Center Experience. Türk Nefroloji Diyaliz ve Transplantasyon Dergisi 27, no.3 (2018): 249 - 253.
MLA Can Özgür,Gümrükçü Gülistan,AKER Fügen Vardar,BAŞ SÜLEYMAN,GÜREN Ali Kaan,Bilek Gunal,APAYDIN SUHEYLA,MANGA ŞAHİN Gülizar Rapidly Progressive Glomerulonephritis: A Single-Center Experience. Türk Nefroloji Diyaliz ve Transplantasyon Dergisi, vol.27, no.3, 2018, ss.249 - 253.
AMA Can Ö,Gümrükçü G,AKER F,BAŞ S,GÜREN A,Bilek G,APAYDIN S,MANGA ŞAHİN G Rapidly Progressive Glomerulonephritis: A Single-Center Experience. Türk Nefroloji Diyaliz ve Transplantasyon Dergisi. 2018; 27(3): 249 - 253.
Vancouver Can Ö,Gümrükçü G,AKER F,BAŞ S,GÜREN A,Bilek G,APAYDIN S,MANGA ŞAHİN G Rapidly Progressive Glomerulonephritis: A Single-Center Experience. Türk Nefroloji Diyaliz ve Transplantasyon Dergisi. 2018; 27(3): 249 - 253.
IEEE Can Ö,Gümrükçü G,AKER F,BAŞ S,GÜREN A,Bilek G,APAYDIN S,MANGA ŞAHİN G "Rapidly Progressive Glomerulonephritis: A Single-Center Experience." Türk Nefroloji Diyaliz ve Transplantasyon Dergisi, 27, ss.249 - 253, 2018.
ISNAD Can, Özgür vd. "Rapidly Progressive Glomerulonephritis: A Single-Center Experience". Türk Nefroloji Diyaliz ve Transplantasyon Dergisi 27/3 (2018), 249-253.