Spinal Cerrahide Gelecek Vaat Eden Moleküler Gelişmeler
Yıl: 2018 Cilt: 25 Sayı: 4 Sayfa Aralığı: 496 - 501 Metin Dili: Türkçe DOI: 10.5505/vtd.2018.41275 İndeks Tarihi: 25-02-2020
Spinal Cerrahide Gelecek Vaat Eden Moleküler Gelişmeler
Öz: Amaç: Bu çalışmada, dünya genelinde yapılan çalışmalariçerisinde, omurga patolojisinin giderilmesinde araştırılan,moleküler düzeyde gerçekleştirilen hücresel bazlı hedeftedavilerin, sistematik olarak incelenip, konu hakkındadaha büyük bir fotoğrafı görebilmek amaçlandı.Gereçler ve Yöntem: Bu çalışmada, dil kısıtlamasıolmaksızın; the cochrane collaboration the cochrane, thecochrane library, ovid medline, proquest, us nationallibrary of medicine National Institutes of Health (NLM)ve PubMed, elektronik veritabanlarında, Ağusto s 1888 ila8 Ocak 2018 tarihleri arasında, “target therapy” ve“spinal surgery” ile ilgili yapılan ve basılmış olan klinikçalışmalar “AND”, “OR” şeklinde literatür taramasıyapılarak incelendi. Elde edilen çalışmalar arasından,inceleme kriterlerini karşılayan makaleler araştırmayadahil edildi. Elde edilen verilerin değerlendirilmesiesnasında sonuçlar, Microsoft Office Excel (2013)Programı yardımı ile adet cinsinden gösterildi.Bulgular: İlk tarama sonrasında ortaya konan 1.812.000adet makaleden, araştırma kriterlerini sağlayan konu ileilişkili, altı adet makalenin olduğu görüldü.Sonuç: Spinal cerrahi alanında kullanılabilecek olan hedeftedavilere yönelik araştırmalar hakkında yeterli bir kanıtbulunamamıştır. Klinik kullanımına ilişkin yorumyapabilmek amacıyla başta in-vivo olmak üzere, dahauzun dönem fonksiyonel sonuçlar veren, randomizekontrollü ve klinik tasarımlara sahip çalışmalara acilihtiyaç duyulmaktadır.
Anahtar Kelime: Promising Molecular Developments in Spinal Surgery
Öz: Introduction: In this study, it was aimed to investigate systematically the cellular based target treatments performed at the molecular level concerning spinal pathology and to show a broader profile about the subject. Materials and Methods: Clinical trials concerning target therapy and spinal surgery conducted between August 1, 1888 and January 8, 2018, in the Cochrane Collaborat ion, the Cochrane Library, Ovid Medline, ProQuest, the National Library of Medicine, and the PubMed electronic databases, were scanned using terms "OR", "AND without language and country restrictions. The articles that met the examination criteria were included in the study. After descriptive statistical evaluation, the results were reported in number with the help of the Microsoft Office Excel (2013) Program. Results: After scanning 1.812.000 articles, it was seen that there were 6 articles that met the research criteria. Conclusion: It was not found sufficient evidence for research into target treatments that can be used in the field of spinal surgery. In order to be able to make a remark on the clinical use, there is an urgent need for invivo studies and for trials with randomized, controlled and clinical designs that provide long-term functional outcomes.
Anahtar Kelime: Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
- Park SY, An HS, Moon SH, Lee HM, Suh SW, Chen D, et al. Neuropathic Pain Components in Patients with Lumbar Spinal Stenosis. Yonsei Med J 2015; 56(4): 1044-1050.
- Kutsal YG, İnanıcı F, Oğuz KK, Alanay A, Palaoğlu S. Bel ağrıları. Hacettepe Tıp Dergisi 2008; 39(1): 180-193.
- Akyuva Y, Karaarslan N, Yilmaz I, Ozbek H, Sirin DY, Gurbuz MS, et al. How scaffolds, which are polymeric drug delivery systems allowing controlled release, can be tested in human primary nucleus pulposus and annulus fibrosus cell culture? Merit Res J Med Med Sci 2017; 5(10): 477-487.
- Van Middelkoop M, Rubinstein SM, Verhagen AP, Ostelo RW, Koes BW, van Tulder MW. Exercise therapy for chronic nonspecific lowback pain. Best Pract Res Clin Rheumatol 2010; 24(2): 193-204.
- Ferreira ML, Smeets RJ, Kamper SJ, Ferreira PH, Machado LA. Can we explain heterogeneity among randomized clinical trials of exercise for chronic back pain? A metaregression analysis of randomized controlled trials. Phys Ther 2010; 90(10): 1383-1403.
- Pillastrini P, Gardenghi I, Bonetti F, Capra F, Guccione A, Mugnai R, et al. An updated overview of clinical guidelines for chronic low back pain management in primary care. Joint Bone Spine 2012; 79(2): 176-185.
- Weiss HR, Goodall D. Rate of complications in scoliosis surgery-a systematic review of the PubMed literature. Scoliosis 2008; 3: 9.
- Çakır CÖ, Çaylı S. Komplikasyonlara genel bakış. Türk Nöroşirürji Dergisi 2013; 23:114- 120.
- Karaarslan N, Kaya YE, Yilmaz I, Ozbek H, Bilir BE, Kaplan N, et al. Will it be possible to prevent lumbar degenerative disc diseases in the future by means of vitamin D receptor gene manipulation? Merit Res J Med Med Sci 2017; 5(10): 500-510.
- Gumustas SA, Yilmaz I, Isyar M, Sirin DY, Batmaz AG, et al. Is it Possible to Expedite Studies on the Effects of Pharmacological Agents on Primary Cell Cultures Obtained from High-grade Fibular Osteosarcoma? J Clin Exp Oncol 2016; 5:6.
- Karaarslan N, Yilmaz I, Ozbek H, Oznam K, Ates O, Erdem I. Is implant washing and wound irrigation with rifampicin effective for preventing surgical site infections in lumbar instrumentation? Turk Neurosurg 2018; 28(1): 1-6. Sirin DY, Kaplan N, Yilmaz I, Karaarslan N, Ozbek H, Akyuva, Y, et al. Investigation of the relationship between different molecular weight hyaluronic acid applications and CHAD, HIF1α, COL2A1 expression in chondrocyte cultures. Experimental and Therapeutic Medicine, 2018; 1: 1-8.
- Sirin, Yasar, Duygu; Karaarslan, Numan; "Evaluation of the effects of pregabalin on chondrocyte proliferation and CHAD, HIF- 1α, and COL2A1 gene expression", Archieves of Medical Science 2018; 3(1): 1-8.
- Lijmer JG, Mol BW, Heisterkamp S, Bonsel GJ, Prins MH, van der Meulen JH, et al. Empirical evidence of design-related bias in studies of diagnostic tests. JAMA 1999; 282(11): 1061-1066.
- Transparent reporting of systematic reviews and meta-analyses. http://www.prismastatement. org/v24. 09.01.2018 tarihinde erişilmiştir.
- Topuk S, Akyuva Y, Karaaslan N, Mutlu CA, Yilmaz I, Isyar M, et al. Is it Possible to Treat Osteosarcoma Using Oligonucleotides Confined into Controlled Release Drug Delivery Systems? Curr Pharm Biotechnol 2017; 18(6): 516-522.
- Ali Gumustas S, Isyar M, Topuk S, Yilmaz I, Oznam K, Onay T, et al. Systematic Evaluation of Drug-Loaded Hydrogels for Application in Osteosarcoma Treatment. Curr Pharm Biotechnol 2016; 17(10): 866-872.
- Liem L, van Dongen E, Huygen FJ, Staats P, Kramer J. The Dorsal Root Ganglion as a Therapeutic Target for Chronic Pain. Reg Anesth Pain Med 2016; 41(4): 511-519.
- Enomoto M, Hirai T, Kaburagi H, Yokota T. Efficient Gene Suppression in Dorsal Root Ganglia and Spinal Cord Using Adeno- Associated Virus Vectors Encoding Short- Hairpin RNA. Methods Mol Biol 2016; 1364: 277-290.
- Niu NK, Yin JJ, Yang YX, Wang ZL, Zhou ZW, He ZX, et al. Novel targeting of PEGylated liposomes for codelivery of TGF- β1 siRNA and four antitubercular drugs to human macrophages for the treatment of mycobacterial infection: a quantitative proteomic study. Drug Des Devel Ther 2015; 9: 4441-4470.
- Hirai T, Enomoto M, Kaburagi H, Sotome S, Yoshida-Tanaka K, Ukegawa M, et al. Intrathecal AAV serotype 9-mediated delivery of shRNA against TRPV1 attenuates thermal hyperalgesia in a mouse model of peripheral nerve injury. Mol Ther 2014; 22(2): 409-419.
- Hirai T, Enomoto M, Machida A, Yamamoto M, Kuwahara H, Tajiri M, et al. Intrathecal shRNA-AAV9 inhibits target protein expression in the spinal cord and dorsal root ganglia of adult mice. Hum Gene Ther Methods 2012; 23(2): 119-127.
- Zou W, Song Z, Guo Q, Liu C, Zhang Z, Zhang Y. Intrathecal lentiviral-mediated RNA interference targeting PKCγ attenuates chronic constriction injury-induced neuropathic pain in rats. Hum Gene Ther 2011; 22(4): 465-475.
- Gökçe A, Yılmaz İ, Tonbul M, Gökay NS, Bircan R, Gökçe Ç. Controlled release from a crosslinker and growth factor embedded hydrogel systems: a systematic review. Okmeydani Tip Derg 2012; 28(1): 25- 34.
- Çakır B. Bias in medical research: types, classification, sources and control measures: review (1). Turkiye Klinikleri J Med Sci 2005; 25(1): 100-110.
| APA | Karaarslan N, YAŞAR ŞİRİN D, Yılmaz İ, özbek h (2018). Spinal Cerrahide Gelecek Vaat Eden Moleküler Gelişmeler. , 496 - 501. 10.5505/vtd.2018.41275 |
| Chicago | Karaarslan Numan,YAŞAR ŞİRİN DUYGU,Yılmaz İbrahim,özbek hanefi Spinal Cerrahide Gelecek Vaat Eden Moleküler Gelişmeler. (2018): 496 - 501. 10.5505/vtd.2018.41275 |
| MLA | Karaarslan Numan,YAŞAR ŞİRİN DUYGU,Yılmaz İbrahim,özbek hanefi Spinal Cerrahide Gelecek Vaat Eden Moleküler Gelişmeler. , 2018, ss.496 - 501. 10.5505/vtd.2018.41275 |
| AMA | Karaarslan N,YAŞAR ŞİRİN D,Yılmaz İ,özbek h Spinal Cerrahide Gelecek Vaat Eden Moleküler Gelişmeler. . 2018; 496 - 501. 10.5505/vtd.2018.41275 |
| Vancouver | Karaarslan N,YAŞAR ŞİRİN D,Yılmaz İ,özbek h Spinal Cerrahide Gelecek Vaat Eden Moleküler Gelişmeler. . 2018; 496 - 501. 10.5505/vtd.2018.41275 |
| IEEE | Karaarslan N,YAŞAR ŞİRİN D,Yılmaz İ,özbek h "Spinal Cerrahide Gelecek Vaat Eden Moleküler Gelişmeler." , ss.496 - 501, 2018. 10.5505/vtd.2018.41275 |
| ISNAD | Karaarslan, Numan vd. "Spinal Cerrahide Gelecek Vaat Eden Moleküler Gelişmeler". (2018), 496-501. https://doi.org/10.5505/vtd.2018.41275 |
| APA | Karaarslan N, YAŞAR ŞİRİN D, Yılmaz İ, özbek h (2018). Spinal Cerrahide Gelecek Vaat Eden Moleküler Gelişmeler. Van Tıp Dergisi, 25(4), 496 - 501. 10.5505/vtd.2018.41275 |
| Chicago | Karaarslan Numan,YAŞAR ŞİRİN DUYGU,Yılmaz İbrahim,özbek hanefi Spinal Cerrahide Gelecek Vaat Eden Moleküler Gelişmeler. Van Tıp Dergisi 25, no.4 (2018): 496 - 501. 10.5505/vtd.2018.41275 |
| MLA | Karaarslan Numan,YAŞAR ŞİRİN DUYGU,Yılmaz İbrahim,özbek hanefi Spinal Cerrahide Gelecek Vaat Eden Moleküler Gelişmeler. Van Tıp Dergisi, vol.25, no.4, 2018, ss.496 - 501. 10.5505/vtd.2018.41275 |
| AMA | Karaarslan N,YAŞAR ŞİRİN D,Yılmaz İ,özbek h Spinal Cerrahide Gelecek Vaat Eden Moleküler Gelişmeler. Van Tıp Dergisi. 2018; 25(4): 496 - 501. 10.5505/vtd.2018.41275 |
| Vancouver | Karaarslan N,YAŞAR ŞİRİN D,Yılmaz İ,özbek h Spinal Cerrahide Gelecek Vaat Eden Moleküler Gelişmeler. Van Tıp Dergisi. 2018; 25(4): 496 - 501. 10.5505/vtd.2018.41275 |
| IEEE | Karaarslan N,YAŞAR ŞİRİN D,Yılmaz İ,özbek h "Spinal Cerrahide Gelecek Vaat Eden Moleküler Gelişmeler." Van Tıp Dergisi, 25, ss.496 - 501, 2018. 10.5505/vtd.2018.41275 |
| ISNAD | Karaarslan, Numan vd. "Spinal Cerrahide Gelecek Vaat Eden Moleküler Gelişmeler". Van Tıp Dergisi 25/4 (2018), 496-501. https://doi.org/10.5505/vtd.2018.41275 |
