Assessment of Cognitive Dysfunction in Hemodialysis Patients By the Mini Mental Test and the Clock Drawing Test
Yıl: 2018 Cilt: 27 Sayı: 3 Sayfa Aralığı: 262 - 266 Metin Dili: İngilizce DOI: 10.5262/tndt.2018.3201 İndeks Tarihi: 26-02-2020
Assessment of Cognitive Dysfunction in Hemodialysis Patients By the Mini Mental Test and the Clock Drawing Test
Öz: OBJECTIVE: Our aim was to assess cognitive dysfunction, which is common in hemodialysis patientsand difficult to diagnose, by an easily applicable test, the Mini Mental State Examination and ClockDrawing Test.MATERIAL and METHODS: Two hundred and sixty six (266, 88.37%) dialysis patients that werefollowed-up at the Nephrology Clinic of Bursa Specialty Training and Research Hospital and privatedialysis centers, and 35 (11.63%) healthy control individuals were involved in our study. Mini MentalState Examination and Clock Drawing Test were applied by a neurologist to the subjects. MMSE andCDT scores of the patients were compared with the control group.RESULTS: Patient and control groups were similar in terms of age, gender, diabetes, and smoking.The rate of hypertension was significantly higher in the dialysis group. Mini Mental State Examinationand Clock Drawing Test success rates were significantly higher in the control group. Orientation,attention and language modalities evaluated in the MMSE were observed to be significantly lower inthe hemodialysis group. A statistically significant inverse correlation was found between registrationmemory and recall scores in MMSE, and urea.CONCLUSION: Cognitive performances of hemodialysis patients must be monitored closely. Therelationship between record memory and recall scores and urea suggests that uremic toxins may affectmemory functions negatively. In addition, cognitive performance can be monitored by Clock DrawingTest in these patients.
Anahtar Kelime: Konular:
Hemodiyaliz Hastalarında Kognitif Disfonksiyonun Kısa Mental Muayene ve Saat Çizme Testi ile Değerlendirilmesi
Öz: AMAÇ: Hemodiyaliz hastalarında sık görülebilen ve tanı almakta zorlanılan kognitif disfonksiyonun kolay uygulanabilir bir test olan kısa mental muayene ve saat çizme testi ile değerlendirmeyi amaçladık. GEREÇ ve YÖNTEMLER: Çalışmaya Bursa Yüksek İhtisas Eğitim Araştırma Hastanesi Nefroloji kliniğinde ve özel diyaliz merkezlerinde takipli olan 266 (%88,37) diyaliz hastası ve 35 (%11,63) sağlıklı kontrol grubu alındı. Hastalar bir nöroloji uzmanı tarafınca değerlendirilip, kısa mental muayene ve saat çizme testi uygulandı. Hastaların kısa mental muayene ve saat çizme testi skorları kontrol grubu ile karşılaştırıldı. BULGULAR: Hasta ve kontrol grubu arasında yaş, cinsiyet, diyabet ve sigara kullanımı açısından fark yoktu. Hipertansiyon görülme oranı diyaliz grubunda anlamlı olarak daha yüksekti. Kısa mental muayene ve saat çizme başarı oranları kontrol grubunda anlamlı olarak daha yüksekti. Kısa mental muayene de değerlendirilen yönelim, dikkat ve lisan modalitelerinde hemodiyaliz grubunda anlamlı derecede düşük olduğu gözlendi. Kısa mental muayenede kayıt hafızası ve hatırlama puanları ile üre arasında negatif yönde anlamlı korelasyon mevcuttu. SONUÇ: Hemodiyaliz hastalarında kognitif fonksiyonlar yakın takip edilmelidir. Kognitif fonksiyonlar kısa mental muayene yanında saat çizme testi ile de güvenle takip edilebilir. Kayıt hafızası ve hatırlama puanları ile üre arasındaki ilişki, üremik toksinlerin bellek fonksiyonlarını negatif yönde etkileyebileceğini düşündürmektedir.
Anahtar Kelime: Konular:
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
- Lambert K, Mullan J, Mansfield K, Lonergan M: A comparison of the extent and pattern of cognitive impairment among predialysis, dialysis and transplant patients: A cross sectional study from Australia. Nephrology (Carlton) 2016.
- Madero M, Gul A, Sarnak MJ: Cognitive function in chronic kidney disease. Semin Dial 2008;21:29-37
- Tiffin-Richards FE, Costa AS, Holschbach B, Frank RD, Vassiliadou A, Kruger T, Kuckuck K, Gross T, Eitner F, Floege J, Schulz JB, Reetz K: The Montreal Cognitive Assessment (MoCA) - a sensitive screening instrument for detecting cognitive impairment in chronic hemodialysis patients. PLoS One 2014;9:e106700
- Janssen J, Koekkoek PS, Moll van Charante EP, Jaap Kappelle L, Biessels GJ, Rutten G: How to choose the most appropriate cognitive test to evaluate cognitive complaints in primary care. BMC Fam Pract 2017;18:101
- Nissenson AR: Epoetin and cognitive function. Am J Kidney Dis 1992;20:21-24
- Stivelman JC: Benefits of anaemia treatment on cognitive function. Nephrol Dial Transplant 2000;15 Suppl 3:29-35
- Abramson JL, Jurkovitz CT, Vaccarino V, Weintraub WS, McClellan W: Chronic kidney disease, anemia, and incident stroke in a middle-aged, community-based population: The ARIC Study. Kidney Int 2003;64:610-615
- Gungen C, Ertan T, Eker E, Yasar R, Engin F: Reliability and validity of the standardized Mini Mental State Examination in the diagnosis of mild dementia in Turkish population. Turk Psikiyatri Derg 2002;13:273-281
- Shulman KI: Clock-drawing: Is it the ideal cognitive screening test? Int J Geriatr Psychiatry 2000;15:548-561
- Cangoz B, Karakoc E, Selekler K: Trail Making Test: Normative data for Turkish elderly population by age, sex and education. J Neurol Sci 2009;283:73-78
- Sehgal AR, Grey SF, DeOreo PB, Whitehouse PJ: Prevalence, recognition, and implications of mental impairment among hemodialysis patients. Am J Kidney Dis 1997;30:41-49
- Murray AM, Tupper DE, Knopman DS, Gilbertson DT, Pederson SL, Li S, Smith GE, Hochhalter AK, Collins AJ, Kane RL: Cognitive impairment in hemodialysis patients is common. Neurology 2006;67:216-223
- Kurella M, Chertow GM, Luan J, Yaffe K: Cognitive impairment in chronic kidney disease. J Am Geriatr Soc 2004;52:1863-1869
- Kurella Tamura M, Wadley V, Yaffe K, McClure LA, Howard G, Go R, Allman RM, Warnock DG, McClellan W: Kidney function and cognitive impairment in US adults: The Reasons for Geographic and Racial Differences in Stroke (REGARDS) Study. Am J Kidney Dis 2008;52:227-234
- Espahbodi F, Khoddad T, Esmaeili L: Evaluation of malnutrition and its association with biochemical parameters in patients with end stage renal disease undergoing hemodialysis using subjective global assessment. Nephrourol Mon 2014;6:e16385
- Rogova IV, Fomin VV, Damulin IV, Shashkova EV: Specific features of cognitive impairments in patients with predialysis chronic kidney disease. Ter Arkh 2013;85:25-30
- Griva K, Thompson D, Jayasena D, Davenport A, Harrison M, Newman SP: Cognitive functioning pre- to post-kidney transplantation--a prospective study. Nephrol Dial Transplant 2006;21:3275-3282
- Fomin VV, Rogova IV, Damulin IV, Mukhin NA: Cognitive impairment in predialysis stages of chronic kidney disease. Zh Nevrol Psikhiatr Im S S Korsakova 2015;115:25-30
- Kalaitzidis RG, Karasavvidou D, Tatsioni A, Balafa O, Pappas K, Spanos G, Pelidou SH, Siamopoulos KC: Risk factors for cognitive dysfunction in CKD and hypertensive subjects. Int Urol Nephrol 2013;45:1637-1646
- Grimm G, Stockenhuber F, Schneeweiss B, Madl C, Zeitlhofer J, Schneider B: Improvement of brain function in hemodialysis patients treated with erythropoietin. Kidney Int 1990;38:480-486
- Singh NP, Sahni V, Wadhwa A, Garg S, Bajaj SK, Kohli R, Agarwal SK: Effect of improvement in anemia on electroneurophysiological markers (P300) of cognitive dysfunction in chronic kidney disease. Hemodial Int 2006;10:267-273
| APA | Yıldız D, Seferoğlu M, güneş A, BÜYÜKKOYUNCU N, YILDIZ A, KILIÇ K, GÜL B, Kahvecioglu S, Oruc A, Sigirli D (2018). Assessment of Cognitive Dysfunction in Hemodialysis Patients By the Mini Mental Test and the Clock Drawing Test. , 262 - 266. 10.5262/tndt.2018.3201 |
| Chicago | Yıldız Demet,Seferoğlu Meral,güneş Aygül,BÜYÜKKOYUNCU Nilüfer,YILDIZ ABDULMECİT,KILIÇ Kasım,GÜL Bülent,Kahvecioglu Serdar,Oruc Aysegul,Sigirli Deniz Assessment of Cognitive Dysfunction in Hemodialysis Patients By the Mini Mental Test and the Clock Drawing Test. (2018): 262 - 266. 10.5262/tndt.2018.3201 |
| MLA | Yıldız Demet,Seferoğlu Meral,güneş Aygül,BÜYÜKKOYUNCU Nilüfer,YILDIZ ABDULMECİT,KILIÇ Kasım,GÜL Bülent,Kahvecioglu Serdar,Oruc Aysegul,Sigirli Deniz Assessment of Cognitive Dysfunction in Hemodialysis Patients By the Mini Mental Test and the Clock Drawing Test. , 2018, ss.262 - 266. 10.5262/tndt.2018.3201 |
| AMA | Yıldız D,Seferoğlu M,güneş A,BÜYÜKKOYUNCU N,YILDIZ A,KILIÇ K,GÜL B,Kahvecioglu S,Oruc A,Sigirli D Assessment of Cognitive Dysfunction in Hemodialysis Patients By the Mini Mental Test and the Clock Drawing Test. . 2018; 262 - 266. 10.5262/tndt.2018.3201 |
| Vancouver | Yıldız D,Seferoğlu M,güneş A,BÜYÜKKOYUNCU N,YILDIZ A,KILIÇ K,GÜL B,Kahvecioglu S,Oruc A,Sigirli D Assessment of Cognitive Dysfunction in Hemodialysis Patients By the Mini Mental Test and the Clock Drawing Test. . 2018; 262 - 266. 10.5262/tndt.2018.3201 |
| IEEE | Yıldız D,Seferoğlu M,güneş A,BÜYÜKKOYUNCU N,YILDIZ A,KILIÇ K,GÜL B,Kahvecioglu S,Oruc A,Sigirli D "Assessment of Cognitive Dysfunction in Hemodialysis Patients By the Mini Mental Test and the Clock Drawing Test." , ss.262 - 266, 2018. 10.5262/tndt.2018.3201 |
| ISNAD | Yıldız, Demet vd. "Assessment of Cognitive Dysfunction in Hemodialysis Patients By the Mini Mental Test and the Clock Drawing Test". (2018), 262-266. https://doi.org/10.5262/tndt.2018.3201 |
| APA | Yıldız D, Seferoğlu M, güneş A, BÜYÜKKOYUNCU N, YILDIZ A, KILIÇ K, GÜL B, Kahvecioglu S, Oruc A, Sigirli D (2018). Assessment of Cognitive Dysfunction in Hemodialysis Patients By the Mini Mental Test and the Clock Drawing Test. Türk Nefroloji Diyaliz ve Transplantasyon Dergisi, 27(3), 262 - 266. 10.5262/tndt.2018.3201 |
| Chicago | Yıldız Demet,Seferoğlu Meral,güneş Aygül,BÜYÜKKOYUNCU Nilüfer,YILDIZ ABDULMECİT,KILIÇ Kasım,GÜL Bülent,Kahvecioglu Serdar,Oruc Aysegul,Sigirli Deniz Assessment of Cognitive Dysfunction in Hemodialysis Patients By the Mini Mental Test and the Clock Drawing Test. Türk Nefroloji Diyaliz ve Transplantasyon Dergisi 27, no.3 (2018): 262 - 266. 10.5262/tndt.2018.3201 |
| MLA | Yıldız Demet,Seferoğlu Meral,güneş Aygül,BÜYÜKKOYUNCU Nilüfer,YILDIZ ABDULMECİT,KILIÇ Kasım,GÜL Bülent,Kahvecioglu Serdar,Oruc Aysegul,Sigirli Deniz Assessment of Cognitive Dysfunction in Hemodialysis Patients By the Mini Mental Test and the Clock Drawing Test. Türk Nefroloji Diyaliz ve Transplantasyon Dergisi, vol.27, no.3, 2018, ss.262 - 266. 10.5262/tndt.2018.3201 |
| AMA | Yıldız D,Seferoğlu M,güneş A,BÜYÜKKOYUNCU N,YILDIZ A,KILIÇ K,GÜL B,Kahvecioglu S,Oruc A,Sigirli D Assessment of Cognitive Dysfunction in Hemodialysis Patients By the Mini Mental Test and the Clock Drawing Test. Türk Nefroloji Diyaliz ve Transplantasyon Dergisi. 2018; 27(3): 262 - 266. 10.5262/tndt.2018.3201 |
| Vancouver | Yıldız D,Seferoğlu M,güneş A,BÜYÜKKOYUNCU N,YILDIZ A,KILIÇ K,GÜL B,Kahvecioglu S,Oruc A,Sigirli D Assessment of Cognitive Dysfunction in Hemodialysis Patients By the Mini Mental Test and the Clock Drawing Test. Türk Nefroloji Diyaliz ve Transplantasyon Dergisi. 2018; 27(3): 262 - 266. 10.5262/tndt.2018.3201 |
| IEEE | Yıldız D,Seferoğlu M,güneş A,BÜYÜKKOYUNCU N,YILDIZ A,KILIÇ K,GÜL B,Kahvecioglu S,Oruc A,Sigirli D "Assessment of Cognitive Dysfunction in Hemodialysis Patients By the Mini Mental Test and the Clock Drawing Test." Türk Nefroloji Diyaliz ve Transplantasyon Dergisi, 27, ss.262 - 266, 2018. 10.5262/tndt.2018.3201 |
| ISNAD | Yıldız, Demet vd. "Assessment of Cognitive Dysfunction in Hemodialysis Patients By the Mini Mental Test and the Clock Drawing Test". Türk Nefroloji Diyaliz ve Transplantasyon Dergisi 27/3 (2018), 262-266. https://doi.org/10.5262/tndt.2018.3201 |
