Introduction: There are many different indications for creating a stoma in general surgery practice. Although stoma takedownis considered as a minor surgical procedure, it may be associated with severe complications and prolonged lengthof hospital stay. The aim of the present study was to compare the postoperative outcomes after Santulli enterostomy andconventionally created stoma closure.Methods: A total of 305 patients who underwent a stoma creation at the jejunal or ileal level between January 2008 andDecember 2016 were included in the study. Patients with Santulli enterostomy were classified in the study group, whereasothers in the control group. Patient demographics, stoma takedown technique, time to oral intake, and length of hospitalstay were recorded.Results: There were 199 male and 106 female patients with a median age of 67 (17–83) years. Of the patients, 76.7% hadloop stoma, 11.8% had double-barrel stoma, 6.2% had Santulli enterostomy, and 5.3% had end stoma. Time to stoma closurewas similar between the groups (24.9 vs. 24.1 weeks, p=0.73). Stapler use was more common in Santulli enterostomy closure(63.2% vs. 34.6%, p=0.01). Oral intake after stoma takedown was earlier (2 vs. 4 days, p<0.001), and length of hospital stay wasshorter (3 vs. 6 days, p=0.001) in the Santulli enterostomy group.Discussion and Conclusion: It is well known that Santulli enterostomy is a good option for patients in whom proximallylocated stoma is unavoidable. The present study showed that it is also advantageous in stoma takedown.