Arterial Function Worsens Faster than Renal Function in Autosomal Dominant Polycystic Kidney Disease
Yıl: 2018 Cilt: 27 Sayı: 1 Sayfa Aralığı: 44 - 48 Metin Dili: İngilizce DOI: 10.5262/tndt.2017.1003.24 İndeks Tarihi: 28-02-2020
Arterial Function Worsens Faster than Renal Function in Autosomal Dominant Polycystic Kidney Disease
Öz: OBJECTIVE: Early arterial stiffness has been shown in autosomal dominant polycystic kidneydisease (ADPKD) patients with preserved renal function. However, to our knowledge, no prospectivestudy evaluated changes in arterial functions in patients with ADPKD. The study aimed to monitor thechanges in renal and arterial functions in patients with ADPKD with preserved renal functions.MATERIAL and METHODS: A total of 25 ADPKD patients and 12 controls were included in thestudy. Data on patient characteristics, biochemical parameters and arterial stiffness were recorded atbaseline and at the end of fourth year. Determination of independent correlates of the change in eGFRand arterial functions was performed by linear regression analyses.RESULTS: There was a similar decline in renal functions over the study period in both groups.However, arterial functions deteriorated more rapidly in the ADPKD group. Having ADPKD was theonly independent factor associated with the decline in arterial functions.CONCLUSION: There were significant decreases in arterial elasticity characteristics in the ADPKDgroup compared with the control group despite a similar decline in renal functions. Monitoring ofarterial stiffness may be as important as monitoring of renal functions in ADPKD patients.
Anahtar Kelime: Konular:
Otozomal Dominant Polikistik Böbrek Hastalığında Arteriyel Fonksiyonlar Böbrek Fonksiyonundan Daha Hızlı Kötüleşmektedir
Öz: AMAÇ: Arteriyel sertlik kötü kardiyovasküler sonuçlar ve mortalitenin artması ile ilişkilidir. Renal fonksiyonları korunmuş otozomal dominant polikistik böbrek hastalığı (ODPBH) hastalarında erken arteriyel sertlik görülmüştür. Bununla birlikte, bildiğimiz kadarıyla, ODPBH’li hastalarda prospektif bir çalışmada arteriyel fonksiyon değişiklikleri değerlendirilmemiştir. Bu çalışma, renal fonksiyonları korunmuş olan ODPBH hastalarında böbrek ve arteriyel fonksiyonlarındaki değişiklikleri izlemeyi amaçlamıştır. GEREÇ ve YÖNTEMLER: Çalışmaya toplam 25 ODPBH hastası ve 12 kontrol alındı. Hasta özellikleri, biyokimyasal parametreler ve arteriyel sertlik verileri başlangıçta ve dördüncü yılda kaydedildi. eGFR ve arteriyel fonksiyonlarda meydana gelen değişikliğin bağımsız faktörlerinin belirlenmesi doğrusal regresyon analizi ile gerçekleştirildi. BULGULAR: Her iki grupta da çalışma süresi boyunca böbrek fonksiyonlarında benzer bir düşüş vardı. Bununla birlikte, ODPBH grubunda arteriyel fonksiyonlar daha da kötüleşti. Arteriyel fonksiyonlarda azalma ile ilişkili tek bağımsız faktör, ODPBH olmaktı. SONUÇ: Bu çalışmada, kontrol grubu ile karşılaştırıldığında, ODPBH grubunda böbrek fonksiyonlarında benzer bir düşüşe rağmen, arteriyel elastisite özelliklerinde anlamlı azalmalar vardı. Noninvaziv olarak kolayca ölçülen arteriyel sertliğin izlenmesi, ODPBH hastalarında böbrek fonksiyonlarının izlenmesi kadar önemli olabilir.
Anahtar Kelime: Konular:
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | YILDIZ A, ERSOY A, sag s, Oruc A, ÇİĞİLLİ E, Ayar Y, GÜLLÜLÜ S, GÜL C (2018). Arterial Function Worsens Faster than Renal Function in Autosomal Dominant Polycystic Kidney Disease. , 44 - 48. 10.5262/tndt.2017.1003.24 |
| Chicago | YILDIZ ABDULMECİT,ERSOY ALPARSLAN,sag saim,Oruc Aysegul,ÇİĞİLLİ Ercan,Ayar Yavuz,GÜLLÜLÜ Sümeyye,GÜL Cuma Bülent Arterial Function Worsens Faster than Renal Function in Autosomal Dominant Polycystic Kidney Disease. (2018): 44 - 48. 10.5262/tndt.2017.1003.24 |
| MLA | YILDIZ ABDULMECİT,ERSOY ALPARSLAN,sag saim,Oruc Aysegul,ÇİĞİLLİ Ercan,Ayar Yavuz,GÜLLÜLÜ Sümeyye,GÜL Cuma Bülent Arterial Function Worsens Faster than Renal Function in Autosomal Dominant Polycystic Kidney Disease. , 2018, ss.44 - 48. 10.5262/tndt.2017.1003.24 |
| AMA | YILDIZ A,ERSOY A,sag s,Oruc A,ÇİĞİLLİ E,Ayar Y,GÜLLÜLÜ S,GÜL C Arterial Function Worsens Faster than Renal Function in Autosomal Dominant Polycystic Kidney Disease. . 2018; 44 - 48. 10.5262/tndt.2017.1003.24 |
| Vancouver | YILDIZ A,ERSOY A,sag s,Oruc A,ÇİĞİLLİ E,Ayar Y,GÜLLÜLÜ S,GÜL C Arterial Function Worsens Faster than Renal Function in Autosomal Dominant Polycystic Kidney Disease. . 2018; 44 - 48. 10.5262/tndt.2017.1003.24 |
| IEEE | YILDIZ A,ERSOY A,sag s,Oruc A,ÇİĞİLLİ E,Ayar Y,GÜLLÜLÜ S,GÜL C "Arterial Function Worsens Faster than Renal Function in Autosomal Dominant Polycystic Kidney Disease." , ss.44 - 48, 2018. 10.5262/tndt.2017.1003.24 |
| ISNAD | YILDIZ, ABDULMECİT vd. "Arterial Function Worsens Faster than Renal Function in Autosomal Dominant Polycystic Kidney Disease". (2018), 44-48. https://doi.org/10.5262/tndt.2017.1003.24 |
| APA | YILDIZ A, ERSOY A, sag s, Oruc A, ÇİĞİLLİ E, Ayar Y, GÜLLÜLÜ S, GÜL C (2018). Arterial Function Worsens Faster than Renal Function in Autosomal Dominant Polycystic Kidney Disease. Türk Nefroloji Diyaliz ve Transplantasyon Dergisi, 27(1), 44 - 48. 10.5262/tndt.2017.1003.24 |
| Chicago | YILDIZ ABDULMECİT,ERSOY ALPARSLAN,sag saim,Oruc Aysegul,ÇİĞİLLİ Ercan,Ayar Yavuz,GÜLLÜLÜ Sümeyye,GÜL Cuma Bülent Arterial Function Worsens Faster than Renal Function in Autosomal Dominant Polycystic Kidney Disease. Türk Nefroloji Diyaliz ve Transplantasyon Dergisi 27, no.1 (2018): 44 - 48. 10.5262/tndt.2017.1003.24 |
| MLA | YILDIZ ABDULMECİT,ERSOY ALPARSLAN,sag saim,Oruc Aysegul,ÇİĞİLLİ Ercan,Ayar Yavuz,GÜLLÜLÜ Sümeyye,GÜL Cuma Bülent Arterial Function Worsens Faster than Renal Function in Autosomal Dominant Polycystic Kidney Disease. Türk Nefroloji Diyaliz ve Transplantasyon Dergisi, vol.27, no.1, 2018, ss.44 - 48. 10.5262/tndt.2017.1003.24 |
| AMA | YILDIZ A,ERSOY A,sag s,Oruc A,ÇİĞİLLİ E,Ayar Y,GÜLLÜLÜ S,GÜL C Arterial Function Worsens Faster than Renal Function in Autosomal Dominant Polycystic Kidney Disease. Türk Nefroloji Diyaliz ve Transplantasyon Dergisi. 2018; 27(1): 44 - 48. 10.5262/tndt.2017.1003.24 |
| Vancouver | YILDIZ A,ERSOY A,sag s,Oruc A,ÇİĞİLLİ E,Ayar Y,GÜLLÜLÜ S,GÜL C Arterial Function Worsens Faster than Renal Function in Autosomal Dominant Polycystic Kidney Disease. Türk Nefroloji Diyaliz ve Transplantasyon Dergisi. 2018; 27(1): 44 - 48. 10.5262/tndt.2017.1003.24 |
| IEEE | YILDIZ A,ERSOY A,sag s,Oruc A,ÇİĞİLLİ E,Ayar Y,GÜLLÜLÜ S,GÜL C "Arterial Function Worsens Faster than Renal Function in Autosomal Dominant Polycystic Kidney Disease." Türk Nefroloji Diyaliz ve Transplantasyon Dergisi, 27, ss.44 - 48, 2018. 10.5262/tndt.2017.1003.24 |
| ISNAD | YILDIZ, ABDULMECİT vd. "Arterial Function Worsens Faster than Renal Function in Autosomal Dominant Polycystic Kidney Disease". Türk Nefroloji Diyaliz ve Transplantasyon Dergisi 27/1 (2018), 44-48. https://doi.org/10.5262/tndt.2017.1003.24 |
