Is there any Association between the Functional Variants of the NOS3 Gene and Psoriasis?

İNALÖZ, Hüseyin Serhat; PEHLİVAN, MUSTAFA; GÜLEL, Aslıhan; Nursal, Ayse Feyda; pehlivan, sacide

Is there any Association between the Functional Variants of the NOS3 Gene and Psoriasis?

Sacide PEHLİVAN, (İstanbul Üniversitesi, İstanbul Tıp Fakültesi, Tıbbi Biyoloji Bölümü, İstanbul, Türkiye)

Hüseyin Serhat İNALÖZ, (Gaziantep Üniversitesi, Tıp Fakültesi, Dermatoloji Bölümü, Gaziantep, Türkiye)

Ayşe Feyda NURSAL, (Hitit Üniversitesi, Tıp Fakültesi, Tıbbi Genetik Ana Bilim Dalı, Çorum, Türkiye)

Aslıhan GÜLEL, (Gaziantep Üniversitesi, Tıp Fakültesi, Dermatoloji Bölümü, Gaziantep, Türkiye)

Mustafa PEHLİVAN (Gaziantep Üniversitesi, Tıp Fakültesi, Hematoloji Bölümü, Gaziantep, Türkiye)

İstanbul Medical Journal

2 0

Yıl: 2018 Cilt: 19 Sayı: 2 Sayfa Aralığı: 152 - 157 Metin Dili: İngilizce İndeks Tarihi: 16-03-2020

Is there any Association between the Functional Variants of the NOS3 Gene and Psoriasis?

Öz:

Introduction: Psoriasis (Ps) is a chronic, immune-mediated inflammatoryskin disorder with an incompletely understood etiology. The aimof this study was to investigate the relationship between the suspectibilityto Ps and G894T (rs1799983) and variable number tandem repeat(VNTR) variants of the endothelial nitric oxide synthase (NOS3) gene.Methods: This is a case-controlled study that included 74 Ps patientsin addition to 74 matched healthy unrelated controls from the samelocality. The NOS3 gene variants were analyzed by polymerase chainreaction (PCR) and/or PCR- restriction fragment lenght polymorphism(PCR-RFLP).Results: The NOS3 G894T TT genotype and T allele were more commonin the Ps group compared to the healthy controls (p=0.000,p=0.001, respectively). The NOS3 VNTR variant BB genotype and Ballele were higher in the patient group than in the control group(p=0.005, p=0.000 respectively). The NOS3 VNTR AA genotype waslower in the patient group (p=0.027). However, a stratified analysisincluding arthritis, the Ps area and severity index (PASI), the age ofonset, and family history revealed no significant correlation betweenthe NOS3 G894T and NOS3 VNTR genotypes (p>0.05).Conclusion: These results suggest that the NOS3 G894T and VNTR variantsare associated with Ps in a Turkish cohort. However, future studiesare needed to understand the genetic role of the NOS3 variantsin the development of Ps.

Anahtar Kelime:

Konular: Tıbbi Araştırmalar Deneysel Genel ve Dahili Tıp

Psoriazis ve NOS3 Gen Fonksiyonel Varyantları Arasında Bir İlişki Var mıdır?

Öz:

Amaç: Psoriazis (Ps) etyolojsi tam olarak anlaşılamayan kronik, immünite ile ilişkili enflamatuar bir deri hastalığıdır. Bu çalışmanın amacı Ps hastalığı yatkınlığı ile endotelyal nitrik asit sentaz (NOS3) geni G894T (rs1799983) ve değişken sayılı ardışık tekrar (VNTR) varyantları arasındaki ilişkiyi saptamaktır. Yöntemler: Bu calışma aynı bölgeden seçilen 74 sağlıklı kontrole ilaveten 74 Ps hastası olmak üzere kontrollü vaka çalışmasıdır. NOS3 gen variantları Polimeraz zincir reaksiyonu (PZR) ve/veya PZR-Sınırlayıcı enzim parça uzunluk polimorfizmi (RFLP) ile analiz edilmiştir. Bulgular: NOS3 G894T TT genotipi ve T alleli sağlıklı kontrollere göre Ps hastalarında daha fazla bulunuyordu (p=0.000, p=0.001, sırasıyla). NOS3 VNTR varyant BB genotipi ve B alleli hasta grubunda konrol grubuna göre daha fazlaydı (p=0.005, p=0.000 sırasıyla). NOS3 VNTR AA genotipi hasta grubunda azdı (p=0.027). Ancak artrit, Ps alan ve şiddet indeksi (PASI), başlangıç yaşı ve aile hikayesine göre yapılan analiz NOS3 G894T ve NOS3 VNTR genotipleri arasında önemli bir ilişki ortaya koymadı (p>0.05). Sonuç: Bu sonuçlar NOS3 G894T ve VNTR varyantların Türk topluluğunda Ps ile ilişkili olduğunu öne sürmektedir. Ancak, Ps oluşmasında NOS3 varyantlarının genetik rolünü anlamak için ileri çalışmalar gerekmektedir.

Anahtar Kelime:

Konular: Tıbbi Araştırmalar Deneysel Genel ve Dahili Tıp

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	pehlivan s, İNALÖZ H, Nursal A, GÜLEL A, PEHLİVAN M (2018). Is there any Association between the Functional Variants of the NOS3 Gene and Psoriasis?. , 152 - 157.
Chicago	pehlivan sacide,İNALÖZ Hüseyin Serhat,Nursal Ayse Feyda,GÜLEL Aslıhan,PEHLİVAN MUSTAFA Is there any Association between the Functional Variants of the NOS3 Gene and Psoriasis?. (2018): 152 - 157.
MLA	pehlivan sacide,İNALÖZ Hüseyin Serhat,Nursal Ayse Feyda,GÜLEL Aslıhan,PEHLİVAN MUSTAFA Is there any Association between the Functional Variants of the NOS3 Gene and Psoriasis?. , 2018, ss.152 - 157.
AMA	pehlivan s,İNALÖZ H,Nursal A,GÜLEL A,PEHLİVAN M Is there any Association between the Functional Variants of the NOS3 Gene and Psoriasis?. . 2018; 152 - 157.
Vancouver	pehlivan s,İNALÖZ H,Nursal A,GÜLEL A,PEHLİVAN M Is there any Association between the Functional Variants of the NOS3 Gene and Psoriasis?. . 2018; 152 - 157.
IEEE	pehlivan s,İNALÖZ H,Nursal A,GÜLEL A,PEHLİVAN M "Is there any Association between the Functional Variants of the NOS3 Gene and Psoriasis?." , ss.152 - 157, 2018.
ISNAD	pehlivan, sacide vd. "Is there any Association between the Functional Variants of the NOS3 Gene and Psoriasis?". (2018), 152-157.

APA	pehlivan s, İNALÖZ H, Nursal A, GÜLEL A, PEHLİVAN M (2018). Is there any Association between the Functional Variants of the NOS3 Gene and Psoriasis?. İstanbul Medical Journal, 19(2), 152 - 157.
Chicago	pehlivan sacide,İNALÖZ Hüseyin Serhat,Nursal Ayse Feyda,GÜLEL Aslıhan,PEHLİVAN MUSTAFA Is there any Association between the Functional Variants of the NOS3 Gene and Psoriasis?. İstanbul Medical Journal 19, no.2 (2018): 152 - 157.
MLA	pehlivan sacide,İNALÖZ Hüseyin Serhat,Nursal Ayse Feyda,GÜLEL Aslıhan,PEHLİVAN MUSTAFA Is there any Association between the Functional Variants of the NOS3 Gene and Psoriasis?. İstanbul Medical Journal, vol.19, no.2, 2018, ss.152 - 157.
AMA	pehlivan s,İNALÖZ H,Nursal A,GÜLEL A,PEHLİVAN M Is there any Association between the Functional Variants of the NOS3 Gene and Psoriasis?. İstanbul Medical Journal. 2018; 19(2): 152 - 157.
Vancouver	pehlivan s,İNALÖZ H,Nursal A,GÜLEL A,PEHLİVAN M Is there any Association between the Functional Variants of the NOS3 Gene and Psoriasis?. İstanbul Medical Journal. 2018; 19(2): 152 - 157.
IEEE	pehlivan s,İNALÖZ H,Nursal A,GÜLEL A,PEHLİVAN M "Is there any Association between the Functional Variants of the NOS3 Gene and Psoriasis?." İstanbul Medical Journal, 19, ss.152 - 157, 2018.
ISNAD	pehlivan, sacide vd. "Is there any Association between the Functional Variants of the NOS3 Gene and Psoriasis?". İstanbul Medical Journal 19/2 (2018), 152-157.