AIM: In this study, it was aimed to investigate the perceptions of openness to change among the operating room nurses in three dimensions and to investigate the differences in levels of perdeption according to demographic characteristics. METHODS: This descriptive study, was performed with 173 operating room nurses between April 2016 and May 2016 who aggreed to participate in the research in public hospitals situated on the European side of Istanbul that gave their consents for the conduction of the study. In the collection of the data, a “Likelihood Scale” consisting of 14 items and 3 subdimensions developed by Smith and Hoy and adapted to Turkish by Demirtaş, and the “Introductory Information Form” containing individual characteristics were used. Before the difference analysis of the data, the normality distribution was checked by the Kolmogorov Smirnov test. Mann -Whitney U test for differences between the two groups and Kruskal Wallis test for the difference between two groups were used. SPSS 21 for Windows computer program was used for the analysis because the data distributions did not fit the normal distribution. A significance level of p<0.05 was accepted for the statistical tests. RESULTS: For the operating room nurses, the total score of Openness To Change Scale was 65.800±9.769 which was found to be at a moderate level. Female participants had received higher mean scores as for openness to change in the management and environment subdimensions, and the differences between these scores were significant (p<0.05). Perceptions of management and environment concerning openness to change were higher in the 41-50 age group participants, and openness to change of nurses were higher in the 31-40 age group (p<0.05). According to professional experiment, the score of the subdimension of management’s openness to change was higher among the murses having ≥16 years of professional experience (p<0.05). Subdimension score of the nurses’openness to change was higher among the married participants, while subdimension score of environment’s openness to change was higher among the single unmarried participants (p<0.05). CONCLUSION: Nurses have a higher role in raising the level of health of society. Successful presentation of nursing services is possible with qualified professionals who have a wide perspective on the applications in the health care system, who conduct researches, and follow scientific developments, According to research results, occupational in-service trainings may be recommended to increase the level of perception of the operating room nurses.