A well-known Ottoman scholar, mufassir, sufi, preacher and poet, Abdulhayy Uskudari who witnessed both 17th and 18th century interpreted some Qur'anic chapters. This study deals with his interpretation of eleven chapters including Maryam, Yasin, al-Fath, al-Rahman, al-Naba, alNaziat, Abasa, al-Takwir, al-Infitar, al-Mutaffifin and al-Kawthar. It firstly introduces the life and works of Uskudari, and then examines these works in terms of his authorship, methodology and style, references and audience. The views of al-Uskudari on some topics of the Qur'anic sciences and his understandings of tafsir based on dirayah (reason) and riwayah (narration) are in detail discussed. Ascertainment of an accurate history of tafsir may only be achieved through multifaceted researches about the literature formed by efforts to comprehend the Qur'an that continue since the Prophet's era. From this point of view, by means of the study it is aimed to reach findings which provide data about the methodology and references used in tafsir works as well as understandings of tafsir in the time and the environment in which the mufassir lived. Although Abdulhayy Uskudari is a being Sufi, it appears that his explanations are linguistic rather than related with Sufism. It can be said that the work with a strong rational aspect is a good example of the height of the scientific level of the Ottoman Sufis.