Aim: To manage and document the nursing care process related to Surgical Site Infection and control in colorectal cancer patient using the Turkish-Nightingale Notes (T-NN) program and test the usability of the program. Method: The sample of the study consisted of 30 patients who underwent colorectal surgery in a university hospital between 1 March and 31 October 2015. All nursing care data provided at hospital and during discharge are coded into the NN program based on the Omaha System. Analyzes were performed using descriptive statistical tests in the SPSS 22 program. Results: The 56.7% of patients were women and 43.3% were men. Four patients in thirty were diagnosed by surgical site infection (13.3%). The nine nursing problems were chosen from the T-NN program were 51.1% “Skin”, 13,2% “Communicable/infectious Condition”, 9.4% “Nutrition” and 0.2% “Sexuality”. In the solution of the problems, “Teaching Guidance, and Counseling; Treatments and Procedures; Case Management and Surveillance initiatives were used. Nursing care/ patient outcomes were assessed at the level of “Knowledge”, “Behavior” and “Status”. Significant improvement was observed at the level of “Knowledge” and “Behavior” in the patients who underwent surgery for potential problems at all levels in patients who developed Surgical Site Infection (CAE) (p<0.001). Conclusion: Turkish-Nightingale Notes (T-NN) program was sufficient to describe the nursing care process for CAE in colorectal surgery patients. T-NN program could be used by infection control nurses. It was suggested that the program be used in different units and with different problems and samples. These efforts can provide the opportunity to use common language in nursing, to base evidence of nursing practices and to reveal the value of nursing care.