Mean Platelet Volume is Increased Only by Subcutaneous Allergen Immunotherapy But not in Allergic Diseases

HAKTANIR ABUL, Mehtap; ORHAN, Fazıl; TOYRAN, Müge; GİNİŞ, Tayfur; VEZİR, Emine; CİVELEK, ERSOY; DİBEK MISIRLIOĞLU, Emine; KOCABAŞ, CAN NACİ; Guvenir, Hakan

doi:10.21911/aai.387

Mean Platelet Volume is Increased Only by Subcutaneous Allergen Immunotherapy But not in Allergic Diseases

Emine VEZİR, (Children’s Hematology Oncology Training and Research Hospital)

Ersoy CİVELEK, (Children’s Hematology Oncology Training and Research Hospital)

Mehtap HAKTANIR ABUL, (Karadeniz Technical University)

Tayfur GİNİŞ, (Children’s Hematology Oncology Training and Research Hospital)

Fazıl ORHAN, (Karadeniz Technical University)

Emine DİBEK MISIRLIOĞLU, (Children’s Hematology Oncology Training and Research Hospital)

Hakan GÜVENİR, (Children’s Hematology Oncology Training and Research Hospital)

Müge TOYRAN, (Children’s Hematology Oncology Training and Research Hospital)

Can Naci KOCABAŞ (Muğla Sıtkı Kocman University)

Astım Allerji İmmünoloji

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Yıl: 2018 Cilt: 16 Sayı: 3 Sayfa Aralığı: 151 - 156 Metin Dili: İngilizce DOI: 10.21911/aai.387 İndeks Tarihi: 10-02-2020

Mean Platelet Volume is Increased Only by Subcutaneous Allergen Immunotherapy But not in Allergic Diseases

Öz:

Objective: Platelets play a role in the pathogenesis of inflammationbeside hemostasis. Mean platelet volume (MPV) is used as abiomarker of platelet activation. Although the platelet’s role in thepathogenesis of allergic diseases is well known, the MPV value isstill controversial in allergic diseases. The objective is to observethe changes of the MPV value in patients with allergic diseasesand patients receiving subcutaneous venom and aeroallergenimmunotherapy (SCIT).Materials and Methods: Patients who are followed by our pediatricallergy and immunology clinic were enrolled in the study. Thestudy group included patients with atopic dermatitis, food allergy,chronic urticaria, allergic rhinitis, asthma and obese asthmatics. Thecontrol group consisted of age- and gender-matched and otherwisehealthy children. The value of MPV was recorded and compared tothe control group’s value. The value of MPV was evaluated at thebeginning and at the second year of SCIT.Results: Study subgroups included patients with atopic dermatitis(n:132), food allergy (n:47), allergic rhinitis (n:48), chronic urticaria(n:102 ), asthma (n:22), and obese asthmatics (n:31). The valueof MPV was not statistically different between the patient andcontrol groups. The severity of atopic dermatitis, autoimmunityof chronic urticaria and presence of obesity in asthmatic patientsdid not influence the value of MPV. The beginning and the secondyear median (IQR) MPV levels of the patients receiving SCIT were 7.5 (7.1-8.1) fl and 8.6 (7.6-9.2) fl respectively in the aeroallergenimmunotherapy (IT) group, and 7.9 (7.2-8.4) fl and 8.8 (8.3-9.3) flrespectively in the venom immunotherapy (VIT) group (p<0.001).Conclusion: This study has shown that MPV changes significantlyover the years in SCIT.

Anahtar Kelime:

Konular: Alerji İmmünoloji

Ortalama Trombosit Hacmi Allerjik Hastalıklarda Artmamakla Birlikte Subkutan İmmünoterapide Artmaktadır

Öz:

Amaç: Trombositler hemostaz yanında inflamasyonun patogenezinde rol oynar. Ortalama trombosit hacmi (MPV) trombosit aktivasyonunun biyolojik belirteci olarak kullanılır. Allerjik hastalıkların patogenezinde trombositlerin rolünün iyi bilinmesine rağmen MPV değeri allerjik hastalıklarda halen tartışmalıdır. Çalışmanın amacı Allerjik hastalıkları olan hastalarda ve subkutan venom ve aeroallerjen immünoterapisi alan hastalarda MPV değerindeki değişiklikleri izlemektir. Gereç ve Yöntem: Pediatrik allerji ve immünoloji kliniğimiz tarafından izlenen hastalar çalışmaya alındı. Allerjik hastalıklar grubuna atopik dermatit, besin allerjisi, kronik ürtiker, allerjik rinit, astım ve obez astımlı hastalar dahil edildi. Kontrol grubuna yaş ve cinsiyet uygun sağlıklı kontroller alındı. Allerjik hastalıklar grubu MPV değerleri ve kontrol grubu MPV değerleri karşılaştırıldı. Subkutan immünoterapi grubuna venom ve aeroallerjen immünoterapisi yapılan hastalar alındı. İmmünoterapi öncesi ve immünoterapinin 2. yılındaki MPV değerleri karşılaştırıldı. Bulgular: Atopik dermatit grubunda 132, besin allerjisi grubunda 47, allerjik rinit grubunda 48, kronik ürtiker grubunda 102, astım grubunda 22, obez astım grubunda 31 hasta mevcuttu. MPV değeri hasta grupları ve kontrol grupları arasında istatistiksel olarak farklı değildi. Astımlı hastalarda obezite eşlik etmesi, atopik dermatitte şiddet skoru sınıflaması, kronik ürtikerde otoimmünite varlığı MPV değerinde istatistiksel anlamlı farklılık oluşturmadı.Subkutan immünoterapi alan hastaların immünoterapi öncesi ve ikinci yıl ortanca MPV değerleri aeroallerjen immünoterapi grubunda sırasıyla 7.5 (7.1-8.1), 8.6 (7.6-9.2); venom immünoterapi grubunda sırasıyla 7.9 (7.2-8.4) fl, 8.8 (8.3-9.3) fl idi (p<0.001). Sonuç: Bu çalışma ile subkutan immünoterapide MPV değerinin yıllar içinde anlamlı olarak değiştiği gösterilmiştir.

Anahtar Kelime:

Konular: Alerji İmmünoloji

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	VEZİR E, CİVELEK E, HAKTANIR ABUL M, GİNİŞ T, ORHAN F, DİBEK MISIRLIOĞLU E, Guvenir H, TOYRAN M, KOCABAŞ C (2018). Mean Platelet Volume is Increased Only by Subcutaneous Allergen Immunotherapy But not in Allergic Diseases. , 151 - 156. 10.21911/aai.387
Chicago	VEZİR Emine,CİVELEK ERSOY,HAKTANIR ABUL Mehtap,GİNİŞ Tayfur,ORHAN Fazıl,DİBEK MISIRLIOĞLU Emine,Guvenir Hakan,TOYRAN Müge,KOCABAŞ CAN NACİ Mean Platelet Volume is Increased Only by Subcutaneous Allergen Immunotherapy But not in Allergic Diseases. (2018): 151 - 156. 10.21911/aai.387
MLA	VEZİR Emine,CİVELEK ERSOY,HAKTANIR ABUL Mehtap,GİNİŞ Tayfur,ORHAN Fazıl,DİBEK MISIRLIOĞLU Emine,Guvenir Hakan,TOYRAN Müge,KOCABAŞ CAN NACİ Mean Platelet Volume is Increased Only by Subcutaneous Allergen Immunotherapy But not in Allergic Diseases. , 2018, ss.151 - 156. 10.21911/aai.387
AMA	VEZİR E,CİVELEK E,HAKTANIR ABUL M,GİNİŞ T,ORHAN F,DİBEK MISIRLIOĞLU E,Guvenir H,TOYRAN M,KOCABAŞ C Mean Platelet Volume is Increased Only by Subcutaneous Allergen Immunotherapy But not in Allergic Diseases. . 2018; 151 - 156. 10.21911/aai.387
Vancouver	VEZİR E,CİVELEK E,HAKTANIR ABUL M,GİNİŞ T,ORHAN F,DİBEK MISIRLIOĞLU E,Guvenir H,TOYRAN M,KOCABAŞ C Mean Platelet Volume is Increased Only by Subcutaneous Allergen Immunotherapy But not in Allergic Diseases. . 2018; 151 - 156. 10.21911/aai.387
IEEE	VEZİR E,CİVELEK E,HAKTANIR ABUL M,GİNİŞ T,ORHAN F,DİBEK MISIRLIOĞLU E,Guvenir H,TOYRAN M,KOCABAŞ C "Mean Platelet Volume is Increased Only by Subcutaneous Allergen Immunotherapy But not in Allergic Diseases." , ss.151 - 156, 2018. 10.21911/aai.387
ISNAD	VEZİR, Emine vd. "Mean Platelet Volume is Increased Only by Subcutaneous Allergen Immunotherapy But not in Allergic Diseases". (2018), 151-156. https://doi.org/10.21911/aai.387

APA	VEZİR E, CİVELEK E, HAKTANIR ABUL M, GİNİŞ T, ORHAN F, DİBEK MISIRLIOĞLU E, Guvenir H, TOYRAN M, KOCABAŞ C (2018). Mean Platelet Volume is Increased Only by Subcutaneous Allergen Immunotherapy But not in Allergic Diseases. Astım Allerji İmmünoloji, 16(3), 151 - 156. 10.21911/aai.387
Chicago	VEZİR Emine,CİVELEK ERSOY,HAKTANIR ABUL Mehtap,GİNİŞ Tayfur,ORHAN Fazıl,DİBEK MISIRLIOĞLU Emine,Guvenir Hakan,TOYRAN Müge,KOCABAŞ CAN NACİ Mean Platelet Volume is Increased Only by Subcutaneous Allergen Immunotherapy But not in Allergic Diseases. Astım Allerji İmmünoloji 16, no.3 (2018): 151 - 156. 10.21911/aai.387
MLA	VEZİR Emine,CİVELEK ERSOY,HAKTANIR ABUL Mehtap,GİNİŞ Tayfur,ORHAN Fazıl,DİBEK MISIRLIOĞLU Emine,Guvenir Hakan,TOYRAN Müge,KOCABAŞ CAN NACİ Mean Platelet Volume is Increased Only by Subcutaneous Allergen Immunotherapy But not in Allergic Diseases. Astım Allerji İmmünoloji, vol.16, no.3, 2018, ss.151 - 156. 10.21911/aai.387
AMA	VEZİR E,CİVELEK E,HAKTANIR ABUL M,GİNİŞ T,ORHAN F,DİBEK MISIRLIOĞLU E,Guvenir H,TOYRAN M,KOCABAŞ C Mean Platelet Volume is Increased Only by Subcutaneous Allergen Immunotherapy But not in Allergic Diseases. Astım Allerji İmmünoloji. 2018; 16(3): 151 - 156. 10.21911/aai.387
Vancouver	VEZİR E,CİVELEK E,HAKTANIR ABUL M,GİNİŞ T,ORHAN F,DİBEK MISIRLIOĞLU E,Guvenir H,TOYRAN M,KOCABAŞ C Mean Platelet Volume is Increased Only by Subcutaneous Allergen Immunotherapy But not in Allergic Diseases. Astım Allerji İmmünoloji. 2018; 16(3): 151 - 156. 10.21911/aai.387
IEEE	VEZİR E,CİVELEK E,HAKTANIR ABUL M,GİNİŞ T,ORHAN F,DİBEK MISIRLIOĞLU E,Guvenir H,TOYRAN M,KOCABAŞ C "Mean Platelet Volume is Increased Only by Subcutaneous Allergen Immunotherapy But not in Allergic Diseases." Astım Allerji İmmünoloji, 16, ss.151 - 156, 2018. 10.21911/aai.387
ISNAD	VEZİR, Emine vd. "Mean Platelet Volume is Increased Only by Subcutaneous Allergen Immunotherapy But not in Allergic Diseases". Astım Allerji İmmünoloji 16/3 (2018), 151-156. https://doi.org/10.21911/aai.387