Serum S100B, NSE, and GRIA1 levels as neurological biomarkers in lead exposure
Yıl: 2018 Cilt: 48 Sayı: 3 Sayfa Aralığı: 449 - 454 Metin Dili: İngilizce DOI: 10.3906/sag-1511-174 İndeks Tarihi: 16-02-2020
Serum S100B, NSE, and GRIA1 levels as neurological biomarkers in lead exposure
Öz: Background/aim: The central nervous system is one of the major targets in lead exposure. Biomarkers for the diagnosis and follow-upof lead exposure have not been identified. In this study, serum S100B, neuron-specific enolase (NSE), and glutamate receptor 1 (GRIA1)levels were determined as possible biomarkers for lead neurotoxicity.Material and methods: Twenty-five subjects with chronic lead exposure and 25 controls were included in the study. NSE and S100Bwere measured by electrochemiluminescence immunoassay with a Cobas E601 analyzer. GRIA1 levels were measured with an ELISAkit using a quantitative sandwich enzyme immunoassay technique.Results: GRIA1 levels were significantly higher in the lead exposure group than in the control group. No significant differences for NSE,S100B, ALT, AST, or creatinine in sera were found between lead exposure and control groups.Conclusion: Subjects with chronic lead exposure are found to have increased glutamate receptor levels and do not seem to have glial orneuronal damage, which can be demonstrated with the elevation of NSE and S100B levels. GRIA1 levels might be used as a biomarkerfor the neurotoxicity of lead.
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Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | FIRAT OĞUZ E, Yılmaz F, Yılmaz Ö, TUTKUN E, ERCAN KARADAĞ M, Sezer S (2018). Serum S100B, NSE, and GRIA1 levels as neurological biomarkers in lead exposure. , 449 - 454. 10.3906/sag-1511-174 |
| Chicago | FIRAT OĞUZ Esra,Yılmaz Fatma Meriç,Yılmaz Ömer Hinç,TUTKUN Engin,ERCAN KARADAĞ MÜJGAN,Sezer Sevilay Serum S100B, NSE, and GRIA1 levels as neurological biomarkers in lead exposure. (2018): 449 - 454. 10.3906/sag-1511-174 |
| MLA | FIRAT OĞUZ Esra,Yılmaz Fatma Meriç,Yılmaz Ömer Hinç,TUTKUN Engin,ERCAN KARADAĞ MÜJGAN,Sezer Sevilay Serum S100B, NSE, and GRIA1 levels as neurological biomarkers in lead exposure. , 2018, ss.449 - 454. 10.3906/sag-1511-174 |
| AMA | FIRAT OĞUZ E,Yılmaz F,Yılmaz Ö,TUTKUN E,ERCAN KARADAĞ M,Sezer S Serum S100B, NSE, and GRIA1 levels as neurological biomarkers in lead exposure. . 2018; 449 - 454. 10.3906/sag-1511-174 |
| Vancouver | FIRAT OĞUZ E,Yılmaz F,Yılmaz Ö,TUTKUN E,ERCAN KARADAĞ M,Sezer S Serum S100B, NSE, and GRIA1 levels as neurological biomarkers in lead exposure. . 2018; 449 - 454. 10.3906/sag-1511-174 |
| IEEE | FIRAT OĞUZ E,Yılmaz F,Yılmaz Ö,TUTKUN E,ERCAN KARADAĞ M,Sezer S "Serum S100B, NSE, and GRIA1 levels as neurological biomarkers in lead exposure." , ss.449 - 454, 2018. 10.3906/sag-1511-174 |
| ISNAD | FIRAT OĞUZ, Esra vd. "Serum S100B, NSE, and GRIA1 levels as neurological biomarkers in lead exposure". (2018), 449-454. https://doi.org/10.3906/sag-1511-174 |
| APA | FIRAT OĞUZ E, Yılmaz F, Yılmaz Ö, TUTKUN E, ERCAN KARADAĞ M, Sezer S (2018). Serum S100B, NSE, and GRIA1 levels as neurological biomarkers in lead exposure. Turkish Journal of Medical Sciences, 48(3), 449 - 454. 10.3906/sag-1511-174 |
| Chicago | FIRAT OĞUZ Esra,Yılmaz Fatma Meriç,Yılmaz Ömer Hinç,TUTKUN Engin,ERCAN KARADAĞ MÜJGAN,Sezer Sevilay Serum S100B, NSE, and GRIA1 levels as neurological biomarkers in lead exposure. Turkish Journal of Medical Sciences 48, no.3 (2018): 449 - 454. 10.3906/sag-1511-174 |
| MLA | FIRAT OĞUZ Esra,Yılmaz Fatma Meriç,Yılmaz Ömer Hinç,TUTKUN Engin,ERCAN KARADAĞ MÜJGAN,Sezer Sevilay Serum S100B, NSE, and GRIA1 levels as neurological biomarkers in lead exposure. Turkish Journal of Medical Sciences, vol.48, no.3, 2018, ss.449 - 454. 10.3906/sag-1511-174 |
| AMA | FIRAT OĞUZ E,Yılmaz F,Yılmaz Ö,TUTKUN E,ERCAN KARADAĞ M,Sezer S Serum S100B, NSE, and GRIA1 levels as neurological biomarkers in lead exposure. Turkish Journal of Medical Sciences. 2018; 48(3): 449 - 454. 10.3906/sag-1511-174 |
| Vancouver | FIRAT OĞUZ E,Yılmaz F,Yılmaz Ö,TUTKUN E,ERCAN KARADAĞ M,Sezer S Serum S100B, NSE, and GRIA1 levels as neurological biomarkers in lead exposure. Turkish Journal of Medical Sciences. 2018; 48(3): 449 - 454. 10.3906/sag-1511-174 |
| IEEE | FIRAT OĞUZ E,Yılmaz F,Yılmaz Ö,TUTKUN E,ERCAN KARADAĞ M,Sezer S "Serum S100B, NSE, and GRIA1 levels as neurological biomarkers in lead exposure." Turkish Journal of Medical Sciences, 48, ss.449 - 454, 2018. 10.3906/sag-1511-174 |
| ISNAD | FIRAT OĞUZ, Esra vd. "Serum S100B, NSE, and GRIA1 levels as neurological biomarkers in lead exposure". Turkish Journal of Medical Sciences 48/3 (2018), 449-454. https://doi.org/10.3906/sag-1511-174 |
