Saliva levels of caspase-1, TNF-α, and IFN-γ in primary Sjögren’s syndrome: oral mucosal abnormalities revisited
Yıl: 2018 Cilt: 48 Sayı: 3 Sayfa Aralığı: 554 - 559 Metin Dili: İngilizce DOI: 10.3906/sag-1710-31 İndeks Tarihi: 16-02-2020
Saliva levels of caspase-1, TNF-α, and IFN-γ in primary Sjögren’s syndrome: oral mucosal abnormalities revisited
Öz: Background/aim: Abnormalities in oral mucosal immunity contribute to complex pathogenesis of primary Sjögren’s syndrome (pSjS).We aimed to measure saliva and serum levels of caspase-1, tumor necrosis factor-alpha (TNF-α) and interferon gamma (IFN-γ) inpatients with pSjS.Materials and methods: We studied 43 pSjS patients fulfilling the AECG criteria and 30 age/sex-matched healthy controls, as wellas 39 rheumatoid arthritis (RA) patients as a disease control group. ESSDAI scores were less than seven in all patients with pSjS,indicating low disease activity. Quantitative analyses were made in serum and whole saliva samples. The statistical analysis wasperformed using SPSS 19.0.Results: While no significant difference was found in serum measurements, saliva levels of TNF-α and caspase-1 were significantlyhigher in pSjS patients versus healthy controls when using the Mann–Whitney U test. On the other hand, in the pSjS group, salivalevels of TNF-α and caspase-1 were also significantly higher compared to the RA group using Student’s t-test. In the pSjS group, thoseparameters did not show any correlation with disease duration, seropositivity, and smoking.Conclusion: Despite low disease activity, saliva TNF-α and caspase-1 levels were found to be significantly higher in the pSjS group,which may suggest a possible advantage of local anticytokine treatments in selected cases.
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- Baer AN, Hall CJ. Sjögren syndrome. In: Hochberg MC, Silman AJ, Smolen JS, Weinblatt ME, Weisman MH, editors. Rheumatology, 6th ed. Vol. II. Philadelphia, PA, USA: Mosby Elsevier; 2015. pp. 1131-1143.
- Fox RI. Sjögren’s syndrome. Lancet 2005; 366: 321-331.
- Liao KP, Karlson EW. Classification and epidemiology of rheumatoid arthritis. In: Hochberg MC, Silman AJ, Smolen JS, Weinblatt ME, Weisman MH, editors. Rheumatology. 6th ed. Vol. I. Philadelphia, PA, USA: Mosby Elsevier, 2015. pp. 691- 697.
- Szodoray P, Alexy P, Brunz JG, Centolay M, Jonsson R. Circulating cytokines in primary Sjögren’s syndrome determined by a multiplex cytokine array system. Scand J Immunol 2004; 59: 592-599.
- Roescher N, Tak PP, Illei GG. Cytokines in Sjögren’s syndrome. Oral Dis 2009; 15: 519-526.
- Baldini C, Rossi C, Ferro F, Santini E, Seccia V, Donati V, Solini A. The P2X7 receptor–inflammasome complex has a role in modulating the inflammatory response in primary Sjögren’s syndrome. J Intern Med 2013; 274: 480-489.
- Baldini C, Gallo A, Perez P, Mosca M, Alevizos I, Bombardieri S. Saliva as an ideal milieu for emerging diagnostic approaches in primary Sjögren’s syndrome. Clin Exp Rheumatol 2012; 30: 785-790.
- Vitali C, Bombardieri S, Jonsson R, Moutsopoulos HM, Alexander EL, Carsons SE, Daniels TE, Fox PC, Fox RI, Kassan SS et al. European Study Group on Classification Criteria for Sjögren’s syndrome. Classification criteria for Sjögren’s syndrome: a revised version of the European criteria proposed by the American-European Consensus Group. Ann Rheum Dis 2002; 61: 554-558.
- Aletaha D, Neogi T, Silman AJ, Funovits J, Felson DT, Bingham CO 3rd, Birnbaum NS, Burmester GR, Bykerk VP, Cohen MD et al. 2010 Rheumatoid arthritis classification criteria: an American College of Rheumatology/European League Against Rheumatism collaborative initiative. Ann Rheum Dis 2010; 69: 1580-1588.
- Seror R, Ravaud P, Bowman SJ, Baron G, Tzioufas A, Theander E, Gottenberg JE, Bootsma H, Mariette X, Vitali C et al. EULAR Sjögren’s syndrome disease activity index: development of a consensus systemic disease activity index for primary Sjögren’s syndrome. Ann Rheum Dis 2010; 69: 1103-1109.
- Prevoo ML, van ‘t Hof MA, Kuper HH, van Leeuwen MA, van de Putte LB, van Riel PL. Modified disease activity scores that include twenty-eight-joint counts. Development and validation in a prospective longitudinal study of patients with rheumatoid arthritis. Arthritis Rheum 1995; 38: 44-48.
- Yamada A, Arakaki R, Kudo Y, Ishimaru N. Targeting IL-1 in Sjögren’s syndrome. Expert Opin Ther Targets 2013; 17: 393- 401.
- Kang EH, Lee YJ, Hyon JY, Yun PY, Song YW. Salivary cytokine profiles in primary Sjögren’s syndrome differ from those in non-Sjögren sicca in terms of TNF-alpha levels and Th-1/Th-2 ratios. Clin Exp Rheumatol 2011; 29: 970-976.
- Fox RI, Kang HI, Ando D, Abrams J, Pisa E. Cytokine mRNA expression in salivary gland biopsies of Sjögren’s syndrome. J Immunol 1994; 152: 5532-5539.
- Zhou J, Kawai T, Yu Q. Pathogenic role of endogenous TNF-α in the development of Sjögren’s like sialadenitis and secretory dysfunction in non-obese diabetic mice. Lab Invest 2017; 97: 458-467.
- Bulosan M, Pauley KM, Yo K, Chan EK, Katz J, Peck AB, Cha S. Inflammatory caspases are critical for enhanced cell death in the target tissue of Sjögren’s syndrome before disease onset. Immunol Cell Biol 2009; 87: 81-90.
- Willeke P, Schotte H, Schlüter B, Erren M, Becker H, Dyong A, Mickholz E, Domschke W, Gaubitz M. Interleukin 1β and tumour necrosis factor alpha secreting cells are increased in the peripheral blood of patients with primary Sjögren’s syndrome. Ann Rheum Dis 2003; 62: 359-362.
- Dubost JJ, Perrier S, Afane M, Viallard JL, Roux-Lombard P, Baudet-Pommel M, Begue C, Kemeny JL, Sauvezie B. IL-1 receptor antagonist in saliva; characterization in normal saliva and reduced concentration in Sjögren’s syndrome (SS). Clin Exp Immunol 1996; 106: 237-242.
- Muraki Y, Tsutsumi A, Takahashi R, Suzuki E, Hayashi T, Chino Y, Goto D, Matsumoto I, Murata H, Noguchi E et al. Polymorphisms of IL-1β gene in Japanese patients with Sjögren’s syndrome and systemic lupus erythematosus. J Rheumatol 2004; 31: 720-725.
- Boumba D, Skopouli FN, Moutsopoulos HM. Cytokine mRNA expression in the labial salivary gland tissues from patients with primary Sjögren’s syndrome. Br J Rheumatol 1995; 34: 326-333.
- Hall JC, Baer AN, Shah AA, Criswell LA, Shiboski CH, Rosen A, Casciola-Rosen L. Molecular subsetting of interferon pathways in Sjögren’s syndrome. Arthritis Rheumatol 2015; 67: 2437-2446.
- Amparo F, Dastjerdi MH, Okanobo A, Ferrari G, Smaga L, Hamrah P, Jurkunas U, Schaumberg DA, Dana R. Topical interleukin 1 receptor antagonist for treatment of dry eye disease: a randomized clinical trial. JAMA Ophthalmol 2013; 131: 715-723.
- Sankar V, Brennan MT, Kok MR, Leakan RA, Smith JA, Manny J, Baum BJ, Pillemer SR. Etanercept in Sjögren’s syndrome: a twelve-week randomized, double-blind, placebo-controlled pilot clinical trial. Arthritis Rheum 2004; 50: 2240-2245.
- Mariette X, Ravaud P, Steinfeld S, Baron G, Goetz J, Hachulla E, Combe B, Puéchal X, Pennec Y, Sauvezie B et al. Inefficacy of infliximab in primary Sjögren’s syndrome: results of the randomized, controlled Trial of Remicade in Primary Sjögren’s Syndrome (TRIPSS). Arthritis Rheum 2004; 50: 1270-1276.
| APA | Karabulut G, KİTAPÇIOĞLU G, ÖZÇAKA YÜKSEL Ö, Alpöz E, Nalbantsoy A, Koçanaoğulları H, GÜCENMEZ S, Keser G, Kabasakal Y (2018). Saliva levels of caspase-1, TNF-α, and IFN-γ in primary Sjögren’s syndrome: oral mucosal abnormalities revisited. , 554 - 559. 10.3906/sag-1710-31 |
| Chicago | Karabulut Gonca,KİTAPÇIOĞLU Gül,ÖZÇAKA YÜKSEL ÖZGÜN,Alpöz Esin,Nalbantsoy Ayse,Koçanaoğulları Hayriye,GÜCENMEZ Sercan,Keser Gökhan,Kabasakal Yasemin Saliva levels of caspase-1, TNF-α, and IFN-γ in primary Sjögren’s syndrome: oral mucosal abnormalities revisited. (2018): 554 - 559. 10.3906/sag-1710-31 |
| MLA | Karabulut Gonca,KİTAPÇIOĞLU Gül,ÖZÇAKA YÜKSEL ÖZGÜN,Alpöz Esin,Nalbantsoy Ayse,Koçanaoğulları Hayriye,GÜCENMEZ Sercan,Keser Gökhan,Kabasakal Yasemin Saliva levels of caspase-1, TNF-α, and IFN-γ in primary Sjögren’s syndrome: oral mucosal abnormalities revisited. , 2018, ss.554 - 559. 10.3906/sag-1710-31 |
| AMA | Karabulut G,KİTAPÇIOĞLU G,ÖZÇAKA YÜKSEL Ö,Alpöz E,Nalbantsoy A,Koçanaoğulları H,GÜCENMEZ S,Keser G,Kabasakal Y Saliva levels of caspase-1, TNF-α, and IFN-γ in primary Sjögren’s syndrome: oral mucosal abnormalities revisited. . 2018; 554 - 559. 10.3906/sag-1710-31 |
| Vancouver | Karabulut G,KİTAPÇIOĞLU G,ÖZÇAKA YÜKSEL Ö,Alpöz E,Nalbantsoy A,Koçanaoğulları H,GÜCENMEZ S,Keser G,Kabasakal Y Saliva levels of caspase-1, TNF-α, and IFN-γ in primary Sjögren’s syndrome: oral mucosal abnormalities revisited. . 2018; 554 - 559. 10.3906/sag-1710-31 |
| IEEE | Karabulut G,KİTAPÇIOĞLU G,ÖZÇAKA YÜKSEL Ö,Alpöz E,Nalbantsoy A,Koçanaoğulları H,GÜCENMEZ S,Keser G,Kabasakal Y "Saliva levels of caspase-1, TNF-α, and IFN-γ in primary Sjögren’s syndrome: oral mucosal abnormalities revisited." , ss.554 - 559, 2018. 10.3906/sag-1710-31 |
| ISNAD | Karabulut, Gonca vd. "Saliva levels of caspase-1, TNF-α, and IFN-γ in primary Sjögren’s syndrome: oral mucosal abnormalities revisited". (2018), 554-559. https://doi.org/10.3906/sag-1710-31 |
| APA | Karabulut G, KİTAPÇIOĞLU G, ÖZÇAKA YÜKSEL Ö, Alpöz E, Nalbantsoy A, Koçanaoğulları H, GÜCENMEZ S, Keser G, Kabasakal Y (2018). Saliva levels of caspase-1, TNF-α, and IFN-γ in primary Sjögren’s syndrome: oral mucosal abnormalities revisited. Turkish Journal of Medical Sciences, 48(3), 554 - 559. 10.3906/sag-1710-31 |
| Chicago | Karabulut Gonca,KİTAPÇIOĞLU Gül,ÖZÇAKA YÜKSEL ÖZGÜN,Alpöz Esin,Nalbantsoy Ayse,Koçanaoğulları Hayriye,GÜCENMEZ Sercan,Keser Gökhan,Kabasakal Yasemin Saliva levels of caspase-1, TNF-α, and IFN-γ in primary Sjögren’s syndrome: oral mucosal abnormalities revisited. Turkish Journal of Medical Sciences 48, no.3 (2018): 554 - 559. 10.3906/sag-1710-31 |
| MLA | Karabulut Gonca,KİTAPÇIOĞLU Gül,ÖZÇAKA YÜKSEL ÖZGÜN,Alpöz Esin,Nalbantsoy Ayse,Koçanaoğulları Hayriye,GÜCENMEZ Sercan,Keser Gökhan,Kabasakal Yasemin Saliva levels of caspase-1, TNF-α, and IFN-γ in primary Sjögren’s syndrome: oral mucosal abnormalities revisited. Turkish Journal of Medical Sciences, vol.48, no.3, 2018, ss.554 - 559. 10.3906/sag-1710-31 |
| AMA | Karabulut G,KİTAPÇIOĞLU G,ÖZÇAKA YÜKSEL Ö,Alpöz E,Nalbantsoy A,Koçanaoğulları H,GÜCENMEZ S,Keser G,Kabasakal Y Saliva levels of caspase-1, TNF-α, and IFN-γ in primary Sjögren’s syndrome: oral mucosal abnormalities revisited. Turkish Journal of Medical Sciences. 2018; 48(3): 554 - 559. 10.3906/sag-1710-31 |
| Vancouver | Karabulut G,KİTAPÇIOĞLU G,ÖZÇAKA YÜKSEL Ö,Alpöz E,Nalbantsoy A,Koçanaoğulları H,GÜCENMEZ S,Keser G,Kabasakal Y Saliva levels of caspase-1, TNF-α, and IFN-γ in primary Sjögren’s syndrome: oral mucosal abnormalities revisited. Turkish Journal of Medical Sciences. 2018; 48(3): 554 - 559. 10.3906/sag-1710-31 |
| IEEE | Karabulut G,KİTAPÇIOĞLU G,ÖZÇAKA YÜKSEL Ö,Alpöz E,Nalbantsoy A,Koçanaoğulları H,GÜCENMEZ S,Keser G,Kabasakal Y "Saliva levels of caspase-1, TNF-α, and IFN-γ in primary Sjögren’s syndrome: oral mucosal abnormalities revisited." Turkish Journal of Medical Sciences, 48, ss.554 - 559, 2018. 10.3906/sag-1710-31 |
| ISNAD | Karabulut, Gonca vd. "Saliva levels of caspase-1, TNF-α, and IFN-γ in primary Sjögren’s syndrome: oral mucosal abnormalities revisited". Turkish Journal of Medical Sciences 48/3 (2018), 554-559. https://doi.org/10.3906/sag-1710-31 |
