Morin and Hesperidin Ameliorate Cisplatin-Induced Hepatotoxicity and Nephrotoxicity in Rats: A Histopathological Study

BALABANLI, Barbaros; APAYDIN, FATMA GÖKÇE; Kaltalioglu, Kaan; COŞKUN CEVHER, ŞULE

Morin and Hesperidin Ameliorate Cisplatin-Induced Hepatotoxicity and Nephrotoxicity in Rats: A Histopathological Study

Fatma Gökçe APAYDIN, (Gazi Üniversitesi)

Kaan KALTALIOĞLU, (Giresun Üniversitesi)

Barbaros BALABANLI, (Gazi Üniversitesi)

Şule COŞKUN CEVHER (Gazi Üniversitesi)

Gazi University Journal of Science

8 0

Yıl: 2018 Cilt: 31 Sayı: 2 Sayfa Aralığı: 399 - 406 Metin Dili: İngilizce İndeks Tarihi: 17-02-2020

Morin and Hesperidin Ameliorate Cisplatin-Induced Hepatotoxicity and Nephrotoxicity in Rats: A Histopathological Study

Öz:

In this study, we investigated that the histopathological changes of rat kidney and liver tissuesafter cisplatin administration and potential beneficial effects of morin and hesperidinadministration. Wistar rats were randomly divided in 7 groups: control, morin (M), hesperidin(H), cisplatin (CP), cisplatin+morin (CP+M), cisplatin+hesperidin (CP+H),cisplatin+morin+hesperidin (CP+M+H). Kidney and liver tissues were collected at the end ofthe experiment and were evaluated histopathological changes. Various histopathologicalchanges in kidney and liver tissues of cisplatin-induced group were revealed. However, pre- andco-treatment of morin and/or hesperidin partially prevented these hepatotoxic and nephrotoxicchanges in cisplatin-induced groups.

Anahtar Kelime:

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

Radwan, R.R., and Abdel Fattah, S.M., “Mechanisms involved in the possible nephroprotective effect of rutin and low dose γ irradiation against cisplatin-induced nephropathy in rats”, Journal of Photochemistry and Photobiology B Biology, 169: 56–62, (2017).
Shaik, A.N., Altomare, D.A., Lesko, L.J., and Trame, M.N., “Development and validation of a LC– MS/MS assay for quantification of cisplatin in rat plasma and urine”, Journal of Chromatography B,1046: 243–249, (2017).
Nasr, A.Y., “Protective effect of aged garlic extract against the oxidative stress induced by cisplatin on blood cells parameters and hepatic antioxidant enzymes in rats”, Toxicology Reports, 1: 682–691, (2014).
Yang, Z., Schumake, L.M., Egorin, M.J., E.G., Zuhowski, Z., and Guo, K.J., “Cisplatin preferentially binds mitochondrial DNA and voltage-dependent anion channel protein in the mitochondrial membrane of head and neck squamous cell carcinoma: possible role in apoptosis”, Clinical Cancer Research, 12: 5817–5825, (2006).
Omar, H.A., Mohameda, W.R., Arafa, E.A., Shehata, B.A., El Sherbincy, G.A., Arab, H.H., and Elgendy, A.N., “Hesperidin alleviates cisplatin-induced hepatotoxicity in rats without inhibiting its antitumor activity”, Pharmacological Reports, 68: 349–356, (2016).
Callejo, A., Durochat, A., Bressieux, S., Saleur, A., Chabbert, C., Juan, I.D., Llorens, J., and Gaboyard-Niay, S., “Dose-dependent cochlear and vestibular toxicity of trans-tympanic cisplatin in the rat”, NeuroToxicology, 60: 1–9, (2017).
Heeba, G.H., Hamza, A.A., and Hassanin, S.O., “Induction of heme oxygenase-1 with hemin alleviates cisplatin-induced reproductive toxicity in male rats and enhances its cytotoxicity in prostate cancer cell line”, Toxicological Letters, 264: 38–50, (2016).
Reddy, K.P., Madhu, P., and Reddy, P.S., “Protective effects of resveratrol against cisplatin-induced testicular and epididymal toxicity in rats”, Food and Chemical Toxicology, 91: 65-72, (2016).
El-Awady, E.E., Moustafa, Y.M., Abo-Elmatty, D.M., and Radwan, A., “Cisplatin-induced cardiotoxicity: Mechanisms and cardioprotective strategies”, European Journal of Pharmacology, 650: 335–341, (2011).
Hassan, M.S., Morgan, A.M., Mekawy, M.M., Zaki, A.R., and Ghazi, Z.M., “Teratogenic effect of cisplatin in rats and the protective role of sodium selenite”, Experimental Toxicology and Pathology, 68: 277–287, (2016).
Szentmihályi, K., Maya, Z., Szénási, G., Máthé, C., Sebestény, A., Albert, M., Hegyi, G., and Blázovics, A., “Changes of essential element content and prevention of cisplatin induced oxidative stress in rat liver by CV247 administration”, European Journal of Integrative Medicine, 8: 36–41, (2016).
Kılıc, C., Gülec-Peker, E.G., Acartürk, F., Sarı Kılıcaslan, S.M., and Coskun-Cevher, S., “Investigation of the effects of local glutathione and chitosan administration on incisional oral mucosal wound healing in rabbits”, Colloid Surface, B 112: 499–507, (2013).
Kaltalioglu, K.,and Coskun-Cevher, S., “Potential of morin and hesperidin in the prevention of cisplatin-induced nephrotoxicity”, Renal Failure, 38: 1291–1299, (2016).
Apaydın, F.G., Bas, H., Kalender, S., and Kalender, Y., “Bendiocarb induced histopathological and biochemical alterations in rat liver and preventive role of vitamins C and E”. Environmental Toxicology and Pharmacology, 49: 148–155, (2017).
Uzun, F.G., and Kalender, Y., “Chlorpyrifos induced hepatotoxic and hematologic changes in rats: The role of quercetin and catechin”, Food and Chemical Toxicology, 55: 549-556, (2013).
Shehata, A.S., Amera, M.G., Abd El-Haleem, M.R., and Karam RA., “The ability of hesperidin compared to that of insulin for preventing osteoporosis induced by type I diabetes in young male albino rats: A histological and biochemical study”, Experimental Toxicology and Pathology, 69: 203–212, (2017).
Zareei, S., Boojar, M.M.A., and Amanlou, M., “Inhibition of liver alanine aminotransferase and aspartate aminotransferase by hesperidin and its aglycone hesperetin: An in vitro and in silico study”, Life Sciences, 178: 49–55, (2017).
Sultana, F., Neog, M.K., and Rasool, M.K., “Targeted delivery of morin, a dietary bioflavanol encapsulated mannosylated liposomes to the macrophages of adjuvant-induced arthritis rats inhibits inflammatory immune response and osteoclastogenesis”, European Journal of Pharmaceutics and Biopharmaceutics, 115: 229–242, (2017).
Khan, M.H.A., and Parvez, S., “Hesperidin ameliorates heavy metal induced toxicity mediated by oxidative stress in brain of Wistar rats”, Journal of Trace Elements in Medicine and Biology, 31: 53–60, (2015).
Mahmoud, A..M, Ashour, M.B., Abdel-Moneim, A., and Ahmed, O.M., “Hesperidin and naringin attenuate hyperglycemia-mediated oxidative stress and proinflammatory cytokine production in high fat fed/streptozotocin-induced type 2 diabetic rats”, Journal of Diabetes and its Complications, 26: 483–90, (2012).
Jung, K., An, J.M., Eom, D., Kang, K.S., and Kim, S., “Preventive effect of fermented black ginseng against cisplatin-induced nephrotoxicity in rats”, Journal of Ginseng Research, 41: 188-194, (2017).
Tilyek, A., Chai, C., Hou, X., Zhou, B., Zhang, C., Cao, Z., and Yu, B., “The protective effects of Ribes diacanthum Pallon cisplatin-induced nephrotoxicity in mice”, Journal of Ethnopharmacology, 178: 297–306, (2016).
Ongjanović, B.I., Marković, S.D., ĐorŠđević, N.Z., Trbojević, I.S., Štajn, A.Š., and Saičić, Z.S., “Cadmium-induced lipid peroxidation and changes in antioxidant defense system in the rat testes: Protective role of coenzyme Q10 and Vitamin E”, Reproductive Toxicology, 29: 191-197, (2010).
Elhalwagy, M.E.A., Darwish, N.S., and Zaher, E.M., “Prophylactic effect of green tea polyphenols against liver and kidney injury induced by fenitrothion insecticide”, Pesticide Biochemistry and Physiology, 91: 81-89, (2008).
Manucha, W., and Vallés, P.G., “Apoptosis modulated by oxidative stress and inflammation during obstructive nephropathy”, Inflammation and Allergy - Drug Targets, 11: 303-12, (2012).
Ozbek, E., “Induction of oxidative stress in kidney”, International Journal of Nephrology, 2012: 465- 897, (2012).
Apaydın, F.G, Bas, H., Kalender, S., Kalender, Y., “Subacute effects of low dose lead nitrate and mercury chloride exposure on kidney of rats”, Environmental Toxicology and Pharmacology, 2016: 41:219-224.
Harborne, J.B., and Williams, C.A., “Advantages in flavonoid research since 1992”, Phytochemistry, 55: 481-504, (2000).
Ke, Y., Liu, C., Hao, J., Lu, L., Lu, N., Wu, Z., Zhu, S., and Chen, X., “Morin inhibits cell proliferation and fibronectin accumulation in rat glomerular mesangial cells cultured under high glucose condition”, Biomedicine and Pharmacotherapy, 84: 622–627, (2016).

APA	APAYDIN F, Kaltalioglu K, BALABANLI B, COŞKUN CEVHER Ş (2018). Morin and Hesperidin Ameliorate Cisplatin-Induced Hepatotoxicity and Nephrotoxicity in Rats: A Histopathological Study. , 399 - 406.
Chicago	APAYDIN FATMA GÖKÇE,Kaltalioglu Kaan,BALABANLI Barbaros,COŞKUN CEVHER ŞULE Morin and Hesperidin Ameliorate Cisplatin-Induced Hepatotoxicity and Nephrotoxicity in Rats: A Histopathological Study. (2018): 399 - 406.
MLA	APAYDIN FATMA GÖKÇE,Kaltalioglu Kaan,BALABANLI Barbaros,COŞKUN CEVHER ŞULE Morin and Hesperidin Ameliorate Cisplatin-Induced Hepatotoxicity and Nephrotoxicity in Rats: A Histopathological Study. , 2018, ss.399 - 406.
AMA	APAYDIN F,Kaltalioglu K,BALABANLI B,COŞKUN CEVHER Ş Morin and Hesperidin Ameliorate Cisplatin-Induced Hepatotoxicity and Nephrotoxicity in Rats: A Histopathological Study. . 2018; 399 - 406.
Vancouver	APAYDIN F,Kaltalioglu K,BALABANLI B,COŞKUN CEVHER Ş Morin and Hesperidin Ameliorate Cisplatin-Induced Hepatotoxicity and Nephrotoxicity in Rats: A Histopathological Study. . 2018; 399 - 406.
IEEE	APAYDIN F,Kaltalioglu K,BALABANLI B,COŞKUN CEVHER Ş "Morin and Hesperidin Ameliorate Cisplatin-Induced Hepatotoxicity and Nephrotoxicity in Rats: A Histopathological Study." , ss.399 - 406, 2018.
ISNAD	APAYDIN, FATMA GÖKÇE vd. "Morin and Hesperidin Ameliorate Cisplatin-Induced Hepatotoxicity and Nephrotoxicity in Rats: A Histopathological Study". (2018), 399-406.

APA	APAYDIN F, Kaltalioglu K, BALABANLI B, COŞKUN CEVHER Ş (2018). Morin and Hesperidin Ameliorate Cisplatin-Induced Hepatotoxicity and Nephrotoxicity in Rats: A Histopathological Study. Gazi University Journal of Science, 31(2), 399 - 406.
Chicago	APAYDIN FATMA GÖKÇE,Kaltalioglu Kaan,BALABANLI Barbaros,COŞKUN CEVHER ŞULE Morin and Hesperidin Ameliorate Cisplatin-Induced Hepatotoxicity and Nephrotoxicity in Rats: A Histopathological Study. Gazi University Journal of Science 31, no.2 (2018): 399 - 406.
MLA	APAYDIN FATMA GÖKÇE,Kaltalioglu Kaan,BALABANLI Barbaros,COŞKUN CEVHER ŞULE Morin and Hesperidin Ameliorate Cisplatin-Induced Hepatotoxicity and Nephrotoxicity in Rats: A Histopathological Study. Gazi University Journal of Science, vol.31, no.2, 2018, ss.399 - 406.
AMA	APAYDIN F,Kaltalioglu K,BALABANLI B,COŞKUN CEVHER Ş Morin and Hesperidin Ameliorate Cisplatin-Induced Hepatotoxicity and Nephrotoxicity in Rats: A Histopathological Study. Gazi University Journal of Science. 2018; 31(2): 399 - 406.
Vancouver	APAYDIN F,Kaltalioglu K,BALABANLI B,COŞKUN CEVHER Ş Morin and Hesperidin Ameliorate Cisplatin-Induced Hepatotoxicity and Nephrotoxicity in Rats: A Histopathological Study. Gazi University Journal of Science. 2018; 31(2): 399 - 406.
IEEE	APAYDIN F,Kaltalioglu K,BALABANLI B,COŞKUN CEVHER Ş "Morin and Hesperidin Ameliorate Cisplatin-Induced Hepatotoxicity and Nephrotoxicity in Rats: A Histopathological Study." Gazi University Journal of Science, 31, ss.399 - 406, 2018.
ISNAD	APAYDIN, FATMA GÖKÇE vd. "Morin and Hesperidin Ameliorate Cisplatin-Induced Hepatotoxicity and Nephrotoxicity in Rats: A Histopathological Study". Gazi University Journal of Science 31/2 (2018), 399-406.