Objective: The study was planned for the purpose of examining the relationship between the factors affecting nursing care negatively and coping strategies for stress among nurses. Material and Methods: The sample of the study, which was conducted as a cross-sectional descriptive study, consisted of 184 nurses working in a university hospital. In the study, “nurse identification form” and “coping methods for stress scale” were used to collect data. Continuous variables were expressed as mean±standard deviation, median (25-75. percentile) and categorical variables were expressed as numbers (percentage). In the comparison of the variables that were not normally distributed between the groups, the Mann Whitney-U test was used and the correlation between the numeric variables was assessed with Spearman correlation analysis. Results: The most frequently used coping methods used by nurses in stressful situations were found as submissive approach (11.51±3.77) and desperate approach (13.22±4.65). It was found out that optimistic approach (p=0.020) and social support seeking scores (p=0.047) of nurses who indicated the condition of ‘being unable to work in the preferred clinic’ as a factor affecting nursing care negatively and desperate approach scores (p=0.019) of nurses who indicated the condition of ‘having insufficient time for care’ were significantly lower; nurses with bachelor’s and higher degree had significantly lower social support seeking scores in some factors affecting nursing care negatively (respectively, p=0.010; p=0.004; p=0.008) and there was a statistically and negatively significant relationship between social support seeking scores and nursing care scores according to the factors affecting nursing care of nurses. Conclusion: It was determined that nurses who were unable to work in the preferred clinic, had insufficient time for care and had bachelor’s and higher degree were unable to use effective methods for coping with stress and as the scores given to nursing care increased, social support seeking method decreased. It was thought that it would be useful to encourage nurses to use effective methods for coping with stress in order to reduce stressors affecting nursing care negatively and increase the quality of nursing care.