Objective: Inhalation agents can have different effects on the middle ear pressure (MEP). We aimed to investigate the effect of sevoflurane anddesflurane, the agents used in patients who do not have any ear pathology and who undergo surgery under general anaesthesia, on MEP.Methods: Fifty adult patients who were scheduled to undergo inguinal hernia and lower extremity surgery were included in our study. All patients were aged between 20 and 60 years and belonged to the American Society of Anesthesiologists (ASA) I-III class. Patients were divided intotwo groups, according to the inhalation agent administered for the surgery: sevofluran, Group S (n=25); and desfluran, Group D (n=25). Anaesthetic agents, intraoperative end tidal carbon dioxide and airway pressures were recorded. The MEP was measured for both ears preoperatively,at the intraoperative 5th, 10th, 15th minutes, and at the postoperative 10th and 30th minutes.Results: The MEP at the intraoperative 10th minute was significantly higher in Group D compared to Group S. In Group D, the MEP increasedsignificantly at the intraoperative 10th and 15th minutes, and postoperative 30th minute, compared to preoperative values. In Group S, the MEPincreased significantly at the postoperative 10th minute, compared to preoperative values.Conclusion: We found that desflurane increases the MEP during the intraoperative and postoperative period, compared to sevoflurane.