Objective: To investigate a possible relationship between abdominal adiposity parametersand the presence of renal cell carcinoma (RCC), and between these adiposity parameters and varioushistopathological tumor findings. Material and Methods: A total of 48 patients (31 males and 17 females, mean age: 60.17±13.39 years) with RCC and 50 control subjects (32 males and 18 females, meanage: 60.26±7.71 years) were enrolled. The medical data and the abdominopelvic computed tomography (CT) examinations of the study groups were retrospectively reviewed. The abdominal adiposityparameters, including visceral adipose tissue (VAT) volume, subcutaneous adipose tissue (SAT) volume, total adipose tissue (TAT) volume, visceral adipose tissue index (VATI), subcutaneous adiposetissue index (SATI), and VAT-to-SAT ratio, were calculated using specialized software. We also notedhistopathological features of the tumors. Results: We found significantly higher SAT volume and SATIin the RCC group in comparison with the control group (p=0.024 and p = 0.001, respectively). The VATvolume and VATI were significantly lower in the patient group, compared to the control group (p =0.001 for both). There was no statistically significant relationship between VAT-to-SAT ratio and thepresence of RCC. No statistically significant relationship between abdominal adiposity parametersand histopathological tumor features was detected (p > 0.05). Conclusion: We designed a volumetricstudy of all slices of abdominopelvic CT examination by using specialized software. As far as we know,this study is the first volumetric study to investigate those relationships. Volumetric adipose tissuemeasurements may be more accurate than area measurements and can easily be performed during abdominopelvic CT examination, which is the routine imaging modality for RCC patients.