Carvacrol alters soluble factors in HCT-116 and HT-29 cell lines

BAŞBINAR, Yasemin; KARACA, Caner; Pakdemirli, Ahu; Leblebici, Asım; Daskin, Ezgi; Sever, Tolga; YİĞİTBAŞI, Türkan

doi:10.3906/sag-1907-173

Carvacrol alters soluble factors in HCT-116 and HT-29 cell lines

Ahu PAKDEMİRLİ, (Dokuz Eylül Üniversitesi)

Caner KARACA, (Dokuz Eylül Üniversitesi)

Tolga SEVER, (Dokuz Eylül Üniversitesi)

Ezgi DAŞKIN, (Dokuz Eylül Üniversitesi)

Asım LEBLEBİCİ, (Dokuz Eylül Üniversitesi)

Türkan YİĞİTBAŞI, (İstanbul Medipol Üniversitesi)

Yasemin BAŞBINAR (Dokuz Eylül Üniversitesi)

Turkish Journal of Medical Sciences

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Yıl: 2020 Cilt: 50 Sayı: 1 Sayfa Aralığı: 271 - 276 Metin Dili: İngilizce DOI: 10.3906/sag-1907-173 İndeks Tarihi: 28-04-2020

Carvacrol alters soluble factors in HCT-116 and HT-29 cell lines

Öz:

Background/aim: Natural products are popular insights for researchers to investigate promising anti-cancer agents since some of thesesubstances have lesser adverse effects restricting the treatment than traditional chemotherapeutic agents. A well-known monoterpeneCarvacrol, widely consumed in Mediterranean cuisine and lower risks of cancer, has efficient anticancer effects. However, the mechanismof action is yet to be discovered.Materials and methods: The investigation aims to illuminate a new perceptive in the role of this substance on colorectal cancertreatment, by the means of differences in a well-defined range of soluble factors. Carvacrol effect on both HT-29 and HCT-116 celllines was evaluated on proliferation and the IC50 values were calculated by the RTCA xCELLigence device. Then MAGPIX assay wasperformed to obtain the changes in soluble factors of the cell lines.Results: The Multiplexing assay suggests some of these factors were altered in favor of surviving and proliferation in aggressive cell lineHCT-116 whereas they were altered against these characters in HT-29, were correlated with the increased IC50 concentration of HCT-116 in carvacrol treatment.Conclusion: The current study indicates that differences in the levels of these soluble factors could modulate the anticancer effect relatedto carvacrol.

Anahtar Kelime:

Konular: Cerrahi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	Pakdemirli A, KARACA C, Sever T, Daskin E, Leblebici A, YİĞİTBAŞI T, BAŞBINAR Y (2020). Carvacrol alters soluble factors in HCT-116 and HT-29 cell lines. , 271 - 276. 10.3906/sag-1907-173
Chicago	Pakdemirli Ahu,KARACA Caner,Sever Tolga,Daskin Ezgi,Leblebici Asım,YİĞİTBAŞI Türkan,BAŞBINAR Yasemin Carvacrol alters soluble factors in HCT-116 and HT-29 cell lines. (2020): 271 - 276. 10.3906/sag-1907-173
MLA	Pakdemirli Ahu,KARACA Caner,Sever Tolga,Daskin Ezgi,Leblebici Asım,YİĞİTBAŞI Türkan,BAŞBINAR Yasemin Carvacrol alters soluble factors in HCT-116 and HT-29 cell lines. , 2020, ss.271 - 276. 10.3906/sag-1907-173
AMA	Pakdemirli A,KARACA C,Sever T,Daskin E,Leblebici A,YİĞİTBAŞI T,BAŞBINAR Y Carvacrol alters soluble factors in HCT-116 and HT-29 cell lines. . 2020; 271 - 276. 10.3906/sag-1907-173
Vancouver	Pakdemirli A,KARACA C,Sever T,Daskin E,Leblebici A,YİĞİTBAŞI T,BAŞBINAR Y Carvacrol alters soluble factors in HCT-116 and HT-29 cell lines. . 2020; 271 - 276. 10.3906/sag-1907-173
IEEE	Pakdemirli A,KARACA C,Sever T,Daskin E,Leblebici A,YİĞİTBAŞI T,BAŞBINAR Y "Carvacrol alters soluble factors in HCT-116 and HT-29 cell lines." , ss.271 - 276, 2020. 10.3906/sag-1907-173
ISNAD	Pakdemirli, Ahu vd. "Carvacrol alters soluble factors in HCT-116 and HT-29 cell lines". (2020), 271-276. https://doi.org/10.3906/sag-1907-173

APA	Pakdemirli A, KARACA C, Sever T, Daskin E, Leblebici A, YİĞİTBAŞI T, BAŞBINAR Y (2020). Carvacrol alters soluble factors in HCT-116 and HT-29 cell lines. Turkish Journal of Medical Sciences, 50(1), 271 - 276. 10.3906/sag-1907-173
Chicago	Pakdemirli Ahu,KARACA Caner,Sever Tolga,Daskin Ezgi,Leblebici Asım,YİĞİTBAŞI Türkan,BAŞBINAR Yasemin Carvacrol alters soluble factors in HCT-116 and HT-29 cell lines. Turkish Journal of Medical Sciences 50, no.1 (2020): 271 - 276. 10.3906/sag-1907-173
MLA	Pakdemirli Ahu,KARACA Caner,Sever Tolga,Daskin Ezgi,Leblebici Asım,YİĞİTBAŞI Türkan,BAŞBINAR Yasemin Carvacrol alters soluble factors in HCT-116 and HT-29 cell lines. Turkish Journal of Medical Sciences, vol.50, no.1, 2020, ss.271 - 276. 10.3906/sag-1907-173
AMA	Pakdemirli A,KARACA C,Sever T,Daskin E,Leblebici A,YİĞİTBAŞI T,BAŞBINAR Y Carvacrol alters soluble factors in HCT-116 and HT-29 cell lines. Turkish Journal of Medical Sciences. 2020; 50(1): 271 - 276. 10.3906/sag-1907-173
Vancouver	Pakdemirli A,KARACA C,Sever T,Daskin E,Leblebici A,YİĞİTBAŞI T,BAŞBINAR Y Carvacrol alters soluble factors in HCT-116 and HT-29 cell lines. Turkish Journal of Medical Sciences. 2020; 50(1): 271 - 276. 10.3906/sag-1907-173
IEEE	Pakdemirli A,KARACA C,Sever T,Daskin E,Leblebici A,YİĞİTBAŞI T,BAŞBINAR Y "Carvacrol alters soluble factors in HCT-116 and HT-29 cell lines." Turkish Journal of Medical Sciences, 50, ss.271 - 276, 2020. 10.3906/sag-1907-173
ISNAD	Pakdemirli, Ahu vd. "Carvacrol alters soluble factors in HCT-116 and HT-29 cell lines". Turkish Journal of Medical Sciences 50/1 (2020), 271-276. https://doi.org/10.3906/sag-1907-173