Yıl: 2019 Cilt: 31 Sayı: 1 Sayfa Aralığı: 21 - 28 Metin Dili: İngilizce DOI: 10.5336/cardiosci.2018-63794 İndeks Tarihi: 28-04-2020

Proportional Serum Lipid Parameters in Coronary Slow Flow Phenomenon

Öz:
Objective: The association between serum lipid parameters and coronary slow-flow(CSF) phenomenon has been searched previously. The aim of our study was to determine the association between proportional serum lipid parameters and CSF. Material and Methods: We enrolled93 stable patients randomly who had undergone coronary angiography and had near-normal coronary arteries with normal and slow coronary flow. Demographic, clinical and laboratory data wererecorded retrospectively. Coronary flow velocity was evaluated by TIMI frame count (TFC). CFSphenomenon was defined as a TFC greater than 27 frames. Corrected TFC was calculated for theleft anterior descending coronary artery. Results: Fifty four patients were in CSF group and 39 patients were in control group. The mean age of the patients in CSF group was significantly higherthan control group (55.4±9.5 vs. 50.5±9.8 years, p= 0.019). Triglyceride (TG) levels was found higherin CSF group than control group (187.3±103.4 mg/dl, 125.3±63.8 mg/dl, p<0.001). Total cholesterolto high density lipoprotein cholesterol ratio (TC/HDL-c), TG/HDL-c, low density lipoprotein cholesterol to HDL-c ratio (LDL-c/HDL-c) and non-HDL-c levels were significantly higher in CSFgroup (p=0.007, p=0.004, p=0.044, p=0.018, respectively). TG and TG/HDL-c were found correlatedwith TFC (r=0.280, r=0.262, respectively). In multivariate logistic regression analysis age, smokingand TG were found statistically significant to predict of CSF. TG was found most associated withthe presence of CSF (OR: 7.516, p=0.001). Conclusion: Higher TG, TC/HDL-c, TG/HDL-c, LDLc/HDL-c and non-HDL-c levels were related with CSF phenomenon.
Anahtar Kelime:

Konular: Periferik Damar Hastalıkları Kalp ve Kalp Damar Sistemi

Koroner Yavaş Akım Fenomeninde Oransal Serum Lipid Parametreleri

Öz:
Amaç: Serum lipid parametreleri ve koroner yavaş akım (KYA) fenomeni arasındaki ilişki daha önce araştırılmıştır. Bizim çalışmamızın amacı oransal lipid parametreleri ile KYA arasındaki ilişkiyi araştırmaktır. Gereç ve Yöntemler: Biz çalışmaya koroner anjiyografi yapılan ve normale yakın koroner arterleri olan, normal ve yavaş koroner akıma sahip 93 stabil hastayı randomize dahil ettik. Demografik, klinik ve laboratuvar verileri retrospektif olarak yerel veri tabanından bulunarak kaydedildi. Koroner akım velositesi miyokard infarktüsünde tromboliz kare sayısı (TFC) ile değerlendirildi. KYA fenomeni TFC’nin 27 kare üzerinde olması olarak tanımlandı. Sol ön inen koroner arter için düzeltilmiş TFC hesaplandı. Bulgular: KYA grubunda 54 hasta, kontrol grubunda 39 hasta vardı. KYA gubunda ortalama yaş, kontrol grubuna göre anlamlı olarak daha fazla saptandı (55,4±9,5 yıl, 50,5±9,8 yıl, p=0,019). Trigliserit (TG) seviyesi KYA grubunda kontrol grubuna göre yüksek bulundu (187,3±103,4 mg/dl, 125,3±63,8 mg/dl, p<0,001). Total kolestrolün yüksek yoğunluklu lipoprotein kolestrolüne oranı (TC/HDL-c), TG/HDL-c, düşük yoğunluklu lipoprotein kolestrolün HDL-c’e oranı (LDL-c/HDL-c) ve non-HDL-c seviyesi KYA grubunda anlamlı olarak yüksek saptandı (sırayla, p=0,007, p=0,004, p=0,044, p=0,018). TG ve TG/HDL-c TFC ile korele bulundu. Çok değişkenli lojistik regresyon analizinde yaş, sigara ve TG değeri KYA’ı öngörmede istatistiksel olarak anlamlı bulundu (r=0,280, r=0,262, sırasıyla). TG değeri KYA ile en fazla ilişkili parametre olarak bulundu (OR: 7,516, p=0,001). Sonuç: Yüksek TC/HDL-c, TG/HDL-c, LDL-c/HDLc, TG ve non-HDL-c seviyeleri KYA fenomeni ile ilişkilidir.
Anahtar Kelime:

Konular: Periferik Damar Hastalıkları Kalp ve Kalp Damar Sistemi
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
  • 1. Tambe AA, Demany MA, Zimmerman HA, Mascarenhas E. Angina pectoris and slow flow velocity of dye in coronary arteries--a new angiographic finding. Am Heart J. 1972;84(1): 66-71. [Crossref]
  • 2. Wang X, Nie SP. The coronary slow flow phenomenon: characteristics, mechanisms and implications. Cardiovasc Diagn Ther. 2011; 1(1):37-43. [PubMed] [PMC]
  • 3. Barutcu I, Sezgin AT, Sezgin N, Gullu H, Esen AM, Topal E, et al. Increased high sensitive CRP level and its significance in pathogenesis of slow coronary flow. Angiology. 2007;58(4): 401-7. [Crossref] [PubMed]
  • 4. Erdogan D, Caliskan M, Gullu H, Sezgin AT, Yildirir A, Muderrisoglu H. Coronary flow reserve is impaired in patients with slow coronary flow. Atherosclerosis. 2007;191(1): 168-74. [Crossref] [PubMed]
  • 5. Kalay N, Aytekin M, Kaya MG, Ozbek K, Karayakalı M, Söğüt E, et al. The relationship between inflammation and slow coronary flow: increased red cell distribution width and serum uric acid levels. Turk Kardiyol Dern Ars. 2011;39(6):463-8. [Crossref] [PubMed]
  • 6. Mosseri M, Yarom R, Gotsman MS, Hasin Y. Histologic evidence for small-vessel coronary artery disease in patients with angina pectoris and patent large coronary arteries. Circulation. 1986;74(5):964-72. [Crossref] [PubMed]
  • 7. Sezgin AT, Sigirci A, Barutcu I, Topal E, Sezgin N, Ozdemir R, et al. Vascular endothelial function in patients with slow coronary flow. Coron Artery Dis. 2003;14(2):155-61. [Crossref] [PubMed]
  • 8. Horjeti B, Goda A. Acute ischemia manifestation in a patient with coronary slow flow phenomenon. J Electrocardiol. 2012;45(3):277-9. [Crossref] [PubMed]
  • 9. Hawkins BM, Stavrakis S, Rousan TA, AbuFadel M, Schechter E. Coronary slow flow-- prevalence and clinical correlations. Circ J. 2012;76(4):936-42. [Crossref] [PubMed]
  • 10. Sanati H, Kiani R, Shakerian F, Firouzi A, Zahedmehr A, Peighambari M, et al. Coronary slow flow phenomenon clinical findings and predictors. Res Cardiovasc Med. 2016;5(1): e30296. [Crossref] [PubMed] [PMC]
  • 11. Sezgin AT, Barutcu I, Sezgin N, Gullu H, Esen AM, Acikgoz N, et al. Contribution of plasma lipid disturbances to vascular endothelial function in patients with slow coronary flow. Angiology. 2006;57(6):694-701. [Crossref] [PubMed]
  • 12. Yilmaz H, Demir I, Uyar Z. Clinical and coronary angiographic characteristics of patients with coronary slow flow. Acta Cardiol. 2008;63(5):579-84. [Crossref] [PubMed]
  • 13. Kimura T, Itoh T, Fusazaki T, Matsui H, Sugawara S, Ogino Y, et al. Low-density lipoprotein-cholesterol/high-density lipoprotein-cholesterol ratio predicts lipid-rich coronary plaque in patients with coronary artery disease--integrated-backscatter intravascular ultrasound study. Circ J. 2010;74(7):1392-8. [Crossref] [PubMed]
  • 14. Salazar MR, Carbajal HA, Espeche WG, Aizpurúa M, Leiva Sisnieguez CE, March CE, et al. Identifying cardiovascular disease risk and outcome: use of the plasma triglyceride/high-density lipoprotein cholesterol concentration ratio versus metabolic syndrome criteria. J Intern Med. 2013;273(6):595-601. [Crossref] [PubMed]
  • 15. Tani S, Matsumoto M, Nakamura Y, Nagao K, Hirayama A. Association of the low-density lipoprotein cholesterol/high-density lipoprotein cholesterol ratio and body mass index with coronary plaque regression. Am J Cardiovasc Drugs. 2012;12(4):279-86. [Crossref] [PubMed]
  • 16. Yang SH, Du Y, Li XL, Zhang Y, Li S, Xu RX, et al. Triglyceride to high-density lipoprotein cholesterol ratio and cardiovascular events in diabetics with coronary artery disease. Am J Med Sci. 2017;354(2):117-24. [Crossref] [PubMed]
  • 17. Gibson CM, Cannon CP, Daley WL, Dodge JT Jr, Alexander B Jr, Marble SJ, et al. TIMI frame count: a quantitative method of assessing coronary artery flow. Circulation. 1996;93(5):879-88. [Crossref] [PubMed]
  • 18. Friedewald WT, Levy RI, Fredrickson DS. Estimation of the concentration of low-density lipoprotein cholesterol in plasma, without use of the preparative ultracentrifuge. Clin Chem. 1972;18(6):499-502. [PubMed]
  • 19. Selcuk H, Selcuk MT, Temizhan A, Maden O, Saydam GS, Ulupinar H, et al. Decreased plasma concentrations of adiponectin in patients with slow coronary flow. Heart Vessels. 2009;24(1):1-7. [Crossref] [PubMed]
  • 20. Aksan G, Soylu K, Aksoy O, Ozdemir M, Yanik A, Yuksel S, et al. The relationship between neutrophil gelatinase-associated lipocalin levels and the slow coronary flow phenomenon. Coron Artery Dis. 2014;25(6):505-9. [Crossref] [PubMed]
  • 21. Yazici M, Demircan S, Aksakal E, Sahin M, Meriç M, Dursun I, et al. [Plasma insulin, glucose and lipid levels, and their relations with corrected TIMI frame count in patients with slow coronary flow]. Anadolu Kardiyol Derg. 2003;3(3):222-6. [PubMed]
  • 22. Fan Y, Yang SS, Yu JB, Hao JH, Han W, Gan RT, et al. [Atorvastatin use and coronary flow reserve in patients with coronary slow flow]. Zhonghua Xin Xue Guan Bing Za Zhi. 2010;38(2):143-6. [PubMed]
  • 23. Yokoyama I, Ohtake T, Momomura S, Yonekura K, Kobayakawa N, Aoyagi T, et al. Altered myocardial vasodilatation in patients with hypertriglyceridemia in anatomically normal coronary arteries. Arterioscler Thromb Vasc Biol. 1998;18(2):294-9. [Crossref] [PubMed]
  • 24. Zengin H, Erbay AR, Okuyucu A, Alaçam H, Yüksel S, Meriç M, et al. The relationship between coronary slow flow phenomenon and urotensin-II: a prospective and controlled study. Anatol J Cardiol. 2015;15(6):475-9. [Crossref] [PubMed] [PMC]
  • 25. Quispe R, Manalac RJ, Faridi KF, Blaha MJ, Toth PP, Kulkarni KR, et al. Relationship of the triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio to the remainder of the lipid profile: The Very Large Database of Lipids-4 (VLDL-4) study. Atherosclerosis. 2015;242(1):243-50. [Crossref] [PubMed]
  • 26. ElshazlyMB, Quispe R,Michos ED, Sniderman AD, Toth PP, Banach M, et al. Patient-level discordance in population percentiles of the total cholesterol to high-density lipoprotein cholesterol ratio in comparison with low-density lipoprotein cholesterol and non-high-density lipoprotein cholesterol: The Very Large Database of Lipids Study (VLDL-2B). Circulation. 2015;132(8):667- 76. [Crossref] [PubMed] [PMC]
  • 27. Arbel Y, Rind E, Banai S, Halkin A, Berliner S, Herz I, et al. Prevalence and predictors of slow flow in angiographically normal coronary arteries. Clin Hemorheol Microcirc. 2012;52(1): 5-14. [PubMed]
APA KALAYCI B, Kalayci S, KÖKTÜRK F (2019). Proportional Serum Lipid Parameters in Coronary Slow Flow Phenomenon. , 21 - 28. 10.5336/cardiosci.2018-63794
Chicago KALAYCI BELMA,Kalayci Suleyman,KÖKTÜRK Fürüzan Proportional Serum Lipid Parameters in Coronary Slow Flow Phenomenon. (2019): 21 - 28. 10.5336/cardiosci.2018-63794
MLA KALAYCI BELMA,Kalayci Suleyman,KÖKTÜRK Fürüzan Proportional Serum Lipid Parameters in Coronary Slow Flow Phenomenon. , 2019, ss.21 - 28. 10.5336/cardiosci.2018-63794
AMA KALAYCI B,Kalayci S,KÖKTÜRK F Proportional Serum Lipid Parameters in Coronary Slow Flow Phenomenon. . 2019; 21 - 28. 10.5336/cardiosci.2018-63794
Vancouver KALAYCI B,Kalayci S,KÖKTÜRK F Proportional Serum Lipid Parameters in Coronary Slow Flow Phenomenon. . 2019; 21 - 28. 10.5336/cardiosci.2018-63794
IEEE KALAYCI B,Kalayci S,KÖKTÜRK F "Proportional Serum Lipid Parameters in Coronary Slow Flow Phenomenon." , ss.21 - 28, 2019. 10.5336/cardiosci.2018-63794
ISNAD KALAYCI, BELMA vd. "Proportional Serum Lipid Parameters in Coronary Slow Flow Phenomenon". (2019), 21-28. https://doi.org/10.5336/cardiosci.2018-63794
APA KALAYCI B, Kalayci S, KÖKTÜRK F (2019). Proportional Serum Lipid Parameters in Coronary Slow Flow Phenomenon. Türkiye Klinikleri Cardiovascular Sciences, 31(1), 21 - 28. 10.5336/cardiosci.2018-63794
Chicago KALAYCI BELMA,Kalayci Suleyman,KÖKTÜRK Fürüzan Proportional Serum Lipid Parameters in Coronary Slow Flow Phenomenon. Türkiye Klinikleri Cardiovascular Sciences 31, no.1 (2019): 21 - 28. 10.5336/cardiosci.2018-63794
MLA KALAYCI BELMA,Kalayci Suleyman,KÖKTÜRK Fürüzan Proportional Serum Lipid Parameters in Coronary Slow Flow Phenomenon. Türkiye Klinikleri Cardiovascular Sciences, vol.31, no.1, 2019, ss.21 - 28. 10.5336/cardiosci.2018-63794
AMA KALAYCI B,Kalayci S,KÖKTÜRK F Proportional Serum Lipid Parameters in Coronary Slow Flow Phenomenon. Türkiye Klinikleri Cardiovascular Sciences. 2019; 31(1): 21 - 28. 10.5336/cardiosci.2018-63794
Vancouver KALAYCI B,Kalayci S,KÖKTÜRK F Proportional Serum Lipid Parameters in Coronary Slow Flow Phenomenon. Türkiye Klinikleri Cardiovascular Sciences. 2019; 31(1): 21 - 28. 10.5336/cardiosci.2018-63794
IEEE KALAYCI B,Kalayci S,KÖKTÜRK F "Proportional Serum Lipid Parameters in Coronary Slow Flow Phenomenon." Türkiye Klinikleri Cardiovascular Sciences, 31, ss.21 - 28, 2019. 10.5336/cardiosci.2018-63794
ISNAD KALAYCI, BELMA vd. "Proportional Serum Lipid Parameters in Coronary Slow Flow Phenomenon". Türkiye Klinikleri Cardiovascular Sciences 31/1 (2019), 21-28. https://doi.org/10.5336/cardiosci.2018-63794