The Relation Between Serum P-selectin, Thrombin-activatable Fibrinolysis Inhibitor Levels, and Carotid Artery Intima-media Thickness in Acute Ischemic Stroke
Yıl: 2020 Cilt: 26 Sayı: 1 Sayfa Aralığı: 19 - 23 Metin Dili: İngilizce DOI: 10.4274/tnd.galenos.2019.26096 İndeks Tarihi: 02-05-2020
The Relation Between Serum P-selectin, Thrombin-activatable Fibrinolysis Inhibitor Levels, and Carotid Artery Intima-media Thickness in Acute Ischemic Stroke
Öz: Objective: Inflammation and migration of leukocytes to the brain parenchyma play a role in atherosclerosis and cerebral ischemic stroke. Migration occurs withthe help of adhesion molecules on the surface of cerebral endothelial cells and leukocytes. P-selectin, an adhesion molecule, is present on the platelet and endothelialsurface and allows leukocytes to loosely adhere to the endothelium, and its increase has been shown in acute ischemic stroke (AIS). Thrombin-activatable fibrinolysisinhibitor (TAFI) is a procarboxypeptidase molecule that can be another marker of AIS, which has been shown to increase the risk of thromboembolism and stroke6-fold. Intima-media thickness (IMT) is thought to be associated with atherosclerotic diseases in carotid ultrasonography (USG) and increased risk of ischemicstroke has been found to be associated with increased carotid IMT. In this study, we investigated the relationship between P-selectin and TAFI levels, which havebeen shown to be effective for AIS via carotid IMT, and is considered significant for atherosclerosis.Materials and Methods: Forty patients with AIS and 22 healthy subjects were included in the study. In both groups, serum P-selectin and TAFI levels werestudied at the time of presentation, and on day 7, day 14, and at one month; carotid IMT and stenosis rates were measured by Doppler USG. P-selectin and TAFIlevels were compared with carotid IMT in both groups.Results: There was no significant difference between P-selectin levels and carotid IMT between the groups; TAFI levels were significantly higher in the patientgroup and were correlated with carotid IMT in both groups.Conclusion: TAFI increase has been suggested to be a marker of early atherosclerosis in asymptomatic atherosclerosis and ischemic stroke. A positive correlationbetween TAFI levels and carotid IMT and stenosis rates have been reported; however, the positive correlation between increased P-selectin levels in AIS and carotidIMT was not detected in our study.
Anahtar Kelime: Konular:
Akut İskemik İnmede Serum P-selektin ve Trombin ile Aktive Olabilen Fibrinolizis İnhibitörü Düzeylerinin Karotis Arter İntima Media Kalınlığı ile İlişkisi
Öz: Amaç: Ateroskleroz ve serebral iskemik inmede enflamatuvar süreçlerin rol aldığı, periferik kandaki lökositlerin beyin parankimine göç ettiği bildirilmiştir. Migrasyon serebral endotel hücreleri ve lökositlerin yüzeyinde bulunan adezyon molekülleri yardımıyla gerçekleşmektedir. Bu adezyon moleküllerinden P-selektin trombosit ve endotel yüzeyinde bulunmakta ve lökositlerin endotele gevşek olarak tutunmalarını sağlamaktadır. Akut iskemik inmede serum P-selektin seviyesinin arttığı gösterilmiştir. Bir başka akut iskemik inme belirteci olabilecek molekül trombin ile aktive olabilen fibrinolizis inhibitörü (TAFI) bir prokarboksipeptidaz olup tromboemboli ve inme riskini 6 artırdığı gösterilmiştir. Karotis arter Doppler ultrasonografi (USG) incelemelerinde intima media kalınlığının (İMK) aterosklerotik hastalıklarla ilişkili olduğu düşünülmekte, karotis İMK arttıkça iskemik inme riskinin arttığı gösterilmiştir. Bu çalışmada akut iskemik inme için farklı mekanizmalar üzerinden etkili olduğu gösterilmiş P-selektin ve TAFI düzeylerinin, ateroskleroz açısından anlamlı kabul edilen karotis İMK ile ilişkisi incelendi. Gereç ve Yöntem: Kırk akut iskemik inme tanılı hasta ve 22 sağlıklı gönüllü çalışmaya alındı. Her iki grupta başvuru anı, 7., 14. gün ve 1. ayda kan serum P-selektin ve TAFI seviyesi çalışıldı, Doppler USG ile karotis İMK ve stenoz oranı ölçüldü. P-selektin ve TAFI düzeylerinin her iki grupta karotis İMK ile karşılaştırılması yapıldı. Bulgular: Hasta ve kontrol grubu arasında P-selektin düzeyi ve karotis internal maksiler arter kalınlığı karşılaştırıldığında anlamlı fark saptanmadı ancak hasta grubunda TAFI düzeyleri kontrol grubundan anlamlı olarak yüksek ve her iki grupta TAFI düzeyleri karotis İMK kalınlığı ile korele bulundu. Sonuç: TAFI artışının asemptomatik aterosklerozun ve iskemik inmede erken aterosklerozun belirteci olabileceği düşünüldü. Akut iskemik inmede gösterilen artmış serum P-selektin düzeyi ile karotis arter İMK arasındaki pozitif korelasyon çalışmamızda saptanmadı ancak serum TAFI düzeyi ile karotis arter İMK ve stenoz oranları arasında pozitif bir ilişki gösterildi.
Anahtar Kelime: Konular:
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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| APA | YILMAZ OKUYAN D, ALADAĞ KURT S, Onay A, Karakus R, Kocer B (2020). The Relation Between Serum P-selectin, Thrombin-activatable Fibrinolysis Inhibitor Levels, and Carotid Artery Intima-media Thickness in Acute Ischemic Stroke. , 19 - 23. 10.4274/tnd.galenos.2019.26096 |
| Chicago | YILMAZ OKUYAN Dilek,ALADAĞ KURT Seda,Onay Aslıhan,Karakus Resul,Kocer Belgin The Relation Between Serum P-selectin, Thrombin-activatable Fibrinolysis Inhibitor Levels, and Carotid Artery Intima-media Thickness in Acute Ischemic Stroke. (2020): 19 - 23. 10.4274/tnd.galenos.2019.26096 |
| MLA | YILMAZ OKUYAN Dilek,ALADAĞ KURT Seda,Onay Aslıhan,Karakus Resul,Kocer Belgin The Relation Between Serum P-selectin, Thrombin-activatable Fibrinolysis Inhibitor Levels, and Carotid Artery Intima-media Thickness in Acute Ischemic Stroke. , 2020, ss.19 - 23. 10.4274/tnd.galenos.2019.26096 |
| AMA | YILMAZ OKUYAN D,ALADAĞ KURT S,Onay A,Karakus R,Kocer B The Relation Between Serum P-selectin, Thrombin-activatable Fibrinolysis Inhibitor Levels, and Carotid Artery Intima-media Thickness in Acute Ischemic Stroke. . 2020; 19 - 23. 10.4274/tnd.galenos.2019.26096 |
| Vancouver | YILMAZ OKUYAN D,ALADAĞ KURT S,Onay A,Karakus R,Kocer B The Relation Between Serum P-selectin, Thrombin-activatable Fibrinolysis Inhibitor Levels, and Carotid Artery Intima-media Thickness in Acute Ischemic Stroke. . 2020; 19 - 23. 10.4274/tnd.galenos.2019.26096 |
| IEEE | YILMAZ OKUYAN D,ALADAĞ KURT S,Onay A,Karakus R,Kocer B "The Relation Between Serum P-selectin, Thrombin-activatable Fibrinolysis Inhibitor Levels, and Carotid Artery Intima-media Thickness in Acute Ischemic Stroke." , ss.19 - 23, 2020. 10.4274/tnd.galenos.2019.26096 |
| ISNAD | YILMAZ OKUYAN, Dilek vd. "The Relation Between Serum P-selectin, Thrombin-activatable Fibrinolysis Inhibitor Levels, and Carotid Artery Intima-media Thickness in Acute Ischemic Stroke". (2020), 19-23. https://doi.org/10.4274/tnd.galenos.2019.26096 |
| APA | YILMAZ OKUYAN D, ALADAĞ KURT S, Onay A, Karakus R, Kocer B (2020). The Relation Between Serum P-selectin, Thrombin-activatable Fibrinolysis Inhibitor Levels, and Carotid Artery Intima-media Thickness in Acute Ischemic Stroke. Türk Nöroloji Dergisi, 26(1), 19 - 23. 10.4274/tnd.galenos.2019.26096 |
| Chicago | YILMAZ OKUYAN Dilek,ALADAĞ KURT Seda,Onay Aslıhan,Karakus Resul,Kocer Belgin The Relation Between Serum P-selectin, Thrombin-activatable Fibrinolysis Inhibitor Levels, and Carotid Artery Intima-media Thickness in Acute Ischemic Stroke. Türk Nöroloji Dergisi 26, no.1 (2020): 19 - 23. 10.4274/tnd.galenos.2019.26096 |
| MLA | YILMAZ OKUYAN Dilek,ALADAĞ KURT Seda,Onay Aslıhan,Karakus Resul,Kocer Belgin The Relation Between Serum P-selectin, Thrombin-activatable Fibrinolysis Inhibitor Levels, and Carotid Artery Intima-media Thickness in Acute Ischemic Stroke. Türk Nöroloji Dergisi, vol.26, no.1, 2020, ss.19 - 23. 10.4274/tnd.galenos.2019.26096 |
| AMA | YILMAZ OKUYAN D,ALADAĞ KURT S,Onay A,Karakus R,Kocer B The Relation Between Serum P-selectin, Thrombin-activatable Fibrinolysis Inhibitor Levels, and Carotid Artery Intima-media Thickness in Acute Ischemic Stroke. Türk Nöroloji Dergisi. 2020; 26(1): 19 - 23. 10.4274/tnd.galenos.2019.26096 |
| Vancouver | YILMAZ OKUYAN D,ALADAĞ KURT S,Onay A,Karakus R,Kocer B The Relation Between Serum P-selectin, Thrombin-activatable Fibrinolysis Inhibitor Levels, and Carotid Artery Intima-media Thickness in Acute Ischemic Stroke. Türk Nöroloji Dergisi. 2020; 26(1): 19 - 23. 10.4274/tnd.galenos.2019.26096 |
| IEEE | YILMAZ OKUYAN D,ALADAĞ KURT S,Onay A,Karakus R,Kocer B "The Relation Between Serum P-selectin, Thrombin-activatable Fibrinolysis Inhibitor Levels, and Carotid Artery Intima-media Thickness in Acute Ischemic Stroke." Türk Nöroloji Dergisi, 26, ss.19 - 23, 2020. 10.4274/tnd.galenos.2019.26096 |
| ISNAD | YILMAZ OKUYAN, Dilek vd. "The Relation Between Serum P-selectin, Thrombin-activatable Fibrinolysis Inhibitor Levels, and Carotid Artery Intima-media Thickness in Acute Ischemic Stroke". Türk Nöroloji Dergisi 26/1 (2020), 19-23. https://doi.org/10.4274/tnd.galenos.2019.26096 |
