Comparison of Ga-68 PSMA positron emission tomography/computerized tomography with Tc-99m MDP bone scan in prostate cancer patients

Background/aim: The aim of our study was to compare Tc-99m MDP bone scan and Ga-68 PSMA PET/CT in terms of detection ofbone metastasis in prostate cancer patients.Materials and methods: A total of 28 prostate cancer patients with bone scan and PSMA PET/CT performed within 90 days wereretrospectively included in our analysis. All bone lesions were scored as negative (score-0), positive (score-1), or suspicious (score-2) formetastasis by two experienced nuclear medicine physicians. Both patient-based and region-based analyses were made for all osseouslesions.Results: On per-patient analysis; sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and accuracywere 72.7%, 52.9%, 50%, 75%, and 60.7%, respectively, for bone scan and 90.9%, 100%, 100%, 94.4%, and 96.4%, respectively, forPSMA PET/CT. On per-region analysis; sensitivity, specificity, PPV, NPV, and accuracy were 76.2%, 80.9%, 57.1%, 91.1%, and 79.8%,respectively, for bone scan and 85.7%, 100%, 100%, 95.5%, and 95.4%, respectively, for PSMA PET/CT.Conclusion: Ga-68 PSMA PET/CT has higher sensitivity, specificity, and accuracy compared to bone scan in terms of bone metastasisdetection in prostate cancer patients. Therefore, it might be the modality of choice for patients with suspicion for metastatic disease,despite negative bone scan and conventional imaging results.

Anahtar Kelime:

Konular: Cerrahi

Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık

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APA	USLU BEŞLİ R, SAGER S, AKGÜN E, Asa S, Şahin O, DEMİRDAĞ Ç, GUNER E, KHOSROSHAHI B, Karayel E, PEHLİVANOĞLU H, AYGÜN A, USLU İ, Talat Z, SÖNMEZOĞLU K (2019). Comparison of Ga-68 PSMA positron emission tomography/computerized tomography with Tc-99m MDP bone scan in prostate cancer patients. , 301 - 310. 10.3906/sag-1807-4
Chicago	USLU BEŞLİ RABİA LEBRİZ,SAGER Sait,AKGÜN Elife,Asa Sertac,Şahin Onur Erdem,DEMİRDAĞ Çetin,GUNER EKREM,KHOSROSHAHI Baresh Razavi,Karayel Emre,PEHLİVANOĞLU Hüseyin,AYGÜN Aslan,USLU İlhami,Talat Zübeyr,SÖNMEZOĞLU Kerim Comparison of Ga-68 PSMA positron emission tomography/computerized tomography with Tc-99m MDP bone scan in prostate cancer patients. (2019): 301 - 310. 10.3906/sag-1807-4
MLA	USLU BEŞLİ RABİA LEBRİZ,SAGER Sait,AKGÜN Elife,Asa Sertac,Şahin Onur Erdem,DEMİRDAĞ Çetin,GUNER EKREM,KHOSROSHAHI Baresh Razavi,Karayel Emre,PEHLİVANOĞLU Hüseyin,AYGÜN Aslan,USLU İlhami,Talat Zübeyr,SÖNMEZOĞLU Kerim Comparison of Ga-68 PSMA positron emission tomography/computerized tomography with Tc-99m MDP bone scan in prostate cancer patients. , 2019, ss.301 - 310. 10.3906/sag-1807-4
AMA	USLU BEŞLİ R,SAGER S,AKGÜN E,Asa S,Şahin O,DEMİRDAĞ Ç,GUNER E,KHOSROSHAHI B,Karayel E,PEHLİVANOĞLU H,AYGÜN A,USLU İ,Talat Z,SÖNMEZOĞLU K Comparison of Ga-68 PSMA positron emission tomography/computerized tomography with Tc-99m MDP bone scan in prostate cancer patients. . 2019; 301 - 310. 10.3906/sag-1807-4
Vancouver	USLU BEŞLİ R,SAGER S,AKGÜN E,Asa S,Şahin O,DEMİRDAĞ Ç,GUNER E,KHOSROSHAHI B,Karayel E,PEHLİVANOĞLU H,AYGÜN A,USLU İ,Talat Z,SÖNMEZOĞLU K Comparison of Ga-68 PSMA positron emission tomography/computerized tomography with Tc-99m MDP bone scan in prostate cancer patients. . 2019; 301 - 310. 10.3906/sag-1807-4
IEEE	USLU BEŞLİ R,SAGER S,AKGÜN E,Asa S,Şahin O,DEMİRDAĞ Ç,GUNER E,KHOSROSHAHI B,Karayel E,PEHLİVANOĞLU H,AYGÜN A,USLU İ,Talat Z,SÖNMEZOĞLU K "Comparison of Ga-68 PSMA positron emission tomography/computerized tomography with Tc-99m MDP bone scan in prostate cancer patients." , ss.301 - 310, 2019. 10.3906/sag-1807-4
ISNAD	USLU BEŞLİ, RABİA LEBRİZ vd. "Comparison of Ga-68 PSMA positron emission tomography/computerized tomography with Tc-99m MDP bone scan in prostate cancer patients". (2019), 301-310. https://doi.org/10.3906/sag-1807-4

APA	USLU BEŞLİ R, SAGER S, AKGÜN E, Asa S, Şahin O, DEMİRDAĞ Ç, GUNER E, KHOSROSHAHI B, Karayel E, PEHLİVANOĞLU H, AYGÜN A, USLU İ, Talat Z, SÖNMEZOĞLU K (2019). Comparison of Ga-68 PSMA positron emission tomography/computerized tomography with Tc-99m MDP bone scan in prostate cancer patients. Turkish Journal of Medical Sciences, 49(1), 301 - 310. 10.3906/sag-1807-4
Chicago	USLU BEŞLİ RABİA LEBRİZ,SAGER Sait,AKGÜN Elife,Asa Sertac,Şahin Onur Erdem,DEMİRDAĞ Çetin,GUNER EKREM,KHOSROSHAHI Baresh Razavi,Karayel Emre,PEHLİVANOĞLU Hüseyin,AYGÜN Aslan,USLU İlhami,Talat Zübeyr,SÖNMEZOĞLU Kerim Comparison of Ga-68 PSMA positron emission tomography/computerized tomography with Tc-99m MDP bone scan in prostate cancer patients. Turkish Journal of Medical Sciences 49, no.1 (2019): 301 - 310. 10.3906/sag-1807-4
MLA	USLU BEŞLİ RABİA LEBRİZ,SAGER Sait,AKGÜN Elife,Asa Sertac,Şahin Onur Erdem,DEMİRDAĞ Çetin,GUNER EKREM,KHOSROSHAHI Baresh Razavi,Karayel Emre,PEHLİVANOĞLU Hüseyin,AYGÜN Aslan,USLU İlhami,Talat Zübeyr,SÖNMEZOĞLU Kerim Comparison of Ga-68 PSMA positron emission tomography/computerized tomography with Tc-99m MDP bone scan in prostate cancer patients. Turkish Journal of Medical Sciences, vol.49, no.1, 2019, ss.301 - 310. 10.3906/sag-1807-4
AMA	USLU BEŞLİ R,SAGER S,AKGÜN E,Asa S,Şahin O,DEMİRDAĞ Ç,GUNER E,KHOSROSHAHI B,Karayel E,PEHLİVANOĞLU H,AYGÜN A,USLU İ,Talat Z,SÖNMEZOĞLU K Comparison of Ga-68 PSMA positron emission tomography/computerized tomography with Tc-99m MDP bone scan in prostate cancer patients. Turkish Journal of Medical Sciences. 2019; 49(1): 301 - 310. 10.3906/sag-1807-4
Vancouver	USLU BEŞLİ R,SAGER S,AKGÜN E,Asa S,Şahin O,DEMİRDAĞ Ç,GUNER E,KHOSROSHAHI B,Karayel E,PEHLİVANOĞLU H,AYGÜN A,USLU İ,Talat Z,SÖNMEZOĞLU K Comparison of Ga-68 PSMA positron emission tomography/computerized tomography with Tc-99m MDP bone scan in prostate cancer patients. Turkish Journal of Medical Sciences. 2019; 49(1): 301 - 310. 10.3906/sag-1807-4
IEEE	USLU BEŞLİ R,SAGER S,AKGÜN E,Asa S,Şahin O,DEMİRDAĞ Ç,GUNER E,KHOSROSHAHI B,Karayel E,PEHLİVANOĞLU H,AYGÜN A,USLU İ,Talat Z,SÖNMEZOĞLU K "Comparison of Ga-68 PSMA positron emission tomography/computerized tomography with Tc-99m MDP bone scan in prostate cancer patients." Turkish Journal of Medical Sciences, 49, ss.301 - 310, 2019. 10.3906/sag-1807-4
ISNAD	USLU BEŞLİ, RABİA LEBRİZ vd. "Comparison of Ga-68 PSMA positron emission tomography/computerized tomography with Tc-99m MDP bone scan in prostate cancer patients". Turkish Journal of Medical Sciences 49/1 (2019), 301-310. https://doi.org/10.3906/sag-1807-4