Yıl: 2019 Cilt: 49 Sayı: 3 Sayfa Aralığı: 746 - 754 Metin Dili: İngilizce DOI: 10.3906/sag-1806-147 İndeks Tarihi: 11-05-2020

Serum S100A12 and S100B proteins are independent predictors of the presence and severity of obstructive sleep apnea

Öz:
Background/aim: Obstructive sleep apnea (OSA) is associated with serious cardiometabolic risks. Early diagnosis and treatmentcompliance are important. For this purpose, research is being carried out on biomarkers associated with the pathogenesis of thedisease. We aimed to investigate whether serum S100A12 and S100B proteins could be used as biochemical markers in OSA patients todetermine disease presence and severity.Materials and methods: A total of 60 (16 women, 44 men) patients with OSA and 50 (20 women, 30 men) controls were enrolled inthis cross-sectional study. Each subject included in the study underwent full-night polysomnography (PSG). The presence and severityof OSA was assessed with the apnea–hypopnea index (AHI). In the OSA group, 17 cases were mild, 18 were moderate, and 25 weresevere. The serum levels of S100A12 and S100B were measured using the enzyme-linked immunosorbent assay (ELISA) technique.These protein levels were compared using Student’s t-test in the patient and control groups. Spearman’s rho correlation coefficients andcorresponding P-values were calculated to determine the correlations between these protein levels and polysomnographic parameters.For evaluating the association between OSA and biomarkers, as well as possible confounding factors with S100A12 and S100B, weemployed multiple linear regression analyses for the patients with OSA.Results: Serum levels of S100A12 and S100B were higher in patients than those in controls (P = 0.01 and P = 0.005, respectively), anda significant correlation was determined between S100A12 and S100B values and AHI (P = 0.0001; P = 0.0001), sleep time with SpO2< 90% (P = 0.032; P = 0.01), minimum SpO2 during sleep (P = 0.019; P = 0.007), and oxygen desaturation index (ODI) (P = 0.001; P= 0.0001). In the linear regression analysis, AHI was independently related with both S100A12 (P <0.0001) and S100B (P =0.011).Receiving operating curves (ROC) identified patients with OSA: AUC for S100A12 = 0.643; AUC for S100B = 0.655 (P < 0.05).Conclusion: Serum levels of S100B and S100A proteins have high diagnostic performance in OSA and are independent predictors ofOSA presence and severity.
Anahtar Kelime:

Konular: Cerrahi
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA DEMİRCİ SAĞLAM G, Zamani A, YOSUNKAYA Ş, Ibrahim K (2019). Serum S100A12 and S100B proteins are independent predictors of the presence and severity of obstructive sleep apnea. , 746 - 754. 10.3906/sag-1806-147
Chicago DEMİRCİ SAĞLAM Gözde,Zamani Adil,YOSUNKAYA Şebnem,Ibrahim Kılınc Serum S100A12 and S100B proteins are independent predictors of the presence and severity of obstructive sleep apnea. (2019): 746 - 754. 10.3906/sag-1806-147
MLA DEMİRCİ SAĞLAM Gözde,Zamani Adil,YOSUNKAYA Şebnem,Ibrahim Kılınc Serum S100A12 and S100B proteins are independent predictors of the presence and severity of obstructive sleep apnea. , 2019, ss.746 - 754. 10.3906/sag-1806-147
AMA DEMİRCİ SAĞLAM G,Zamani A,YOSUNKAYA Ş,Ibrahim K Serum S100A12 and S100B proteins are independent predictors of the presence and severity of obstructive sleep apnea. . 2019; 746 - 754. 10.3906/sag-1806-147
Vancouver DEMİRCİ SAĞLAM G,Zamani A,YOSUNKAYA Ş,Ibrahim K Serum S100A12 and S100B proteins are independent predictors of the presence and severity of obstructive sleep apnea. . 2019; 746 - 754. 10.3906/sag-1806-147
IEEE DEMİRCİ SAĞLAM G,Zamani A,YOSUNKAYA Ş,Ibrahim K "Serum S100A12 and S100B proteins are independent predictors of the presence and severity of obstructive sleep apnea." , ss.746 - 754, 2019. 10.3906/sag-1806-147
ISNAD DEMİRCİ SAĞLAM, Gözde vd. "Serum S100A12 and S100B proteins are independent predictors of the presence and severity of obstructive sleep apnea". (2019), 746-754. https://doi.org/10.3906/sag-1806-147
APA DEMİRCİ SAĞLAM G, Zamani A, YOSUNKAYA Ş, Ibrahim K (2019). Serum S100A12 and S100B proteins are independent predictors of the presence and severity of obstructive sleep apnea. Turkish Journal of Medical Sciences, 49(3), 746 - 754. 10.3906/sag-1806-147
Chicago DEMİRCİ SAĞLAM Gözde,Zamani Adil,YOSUNKAYA Şebnem,Ibrahim Kılınc Serum S100A12 and S100B proteins are independent predictors of the presence and severity of obstructive sleep apnea. Turkish Journal of Medical Sciences 49, no.3 (2019): 746 - 754. 10.3906/sag-1806-147
MLA DEMİRCİ SAĞLAM Gözde,Zamani Adil,YOSUNKAYA Şebnem,Ibrahim Kılınc Serum S100A12 and S100B proteins are independent predictors of the presence and severity of obstructive sleep apnea. Turkish Journal of Medical Sciences, vol.49, no.3, 2019, ss.746 - 754. 10.3906/sag-1806-147
AMA DEMİRCİ SAĞLAM G,Zamani A,YOSUNKAYA Ş,Ibrahim K Serum S100A12 and S100B proteins are independent predictors of the presence and severity of obstructive sleep apnea. Turkish Journal of Medical Sciences. 2019; 49(3): 746 - 754. 10.3906/sag-1806-147
Vancouver DEMİRCİ SAĞLAM G,Zamani A,YOSUNKAYA Ş,Ibrahim K Serum S100A12 and S100B proteins are independent predictors of the presence and severity of obstructive sleep apnea. Turkish Journal of Medical Sciences. 2019; 49(3): 746 - 754. 10.3906/sag-1806-147
IEEE DEMİRCİ SAĞLAM G,Zamani A,YOSUNKAYA Ş,Ibrahim K "Serum S100A12 and S100B proteins are independent predictors of the presence and severity of obstructive sleep apnea." Turkish Journal of Medical Sciences, 49, ss.746 - 754, 2019. 10.3906/sag-1806-147
ISNAD DEMİRCİ SAĞLAM, Gözde vd. "Serum S100A12 and S100B proteins are independent predictors of the presence and severity of obstructive sleep apnea". Turkish Journal of Medical Sciences 49/3 (2019), 746-754. https://doi.org/10.3906/sag-1806-147