Comparative Evaluation of Two Doses of Etoricoxib (90 mg and 120 mg) as PreEmptive Analgesic for Post-Operative Pain Relief in Mandibular Fracture Surgery Under General Anaesthesia: A Prospective, Randomised, Double-Blinded, PlaceboControlled Trial
Yıl: 2020 Cilt: 48 Sayı: 1 Sayfa Aralığı: 24 - 30 Metin Dili: İngilizce DOI: 10.5152/TJAR.2019.54614 İndeks Tarihi: 06-11-2020
Comparative Evaluation of Two Doses of Etoricoxib (90 mg and 120 mg) as PreEmptive Analgesic for Post-Operative Pain Relief in Mandibular Fracture Surgery Under General Anaesthesia: A Prospective, Randomised, Double-Blinded, PlaceboControlled Trial
Öz: Objective: This trial investigated the post operative analgesic efficacy of oarl etoricoxib 90 mg and 120 mg and a placebo in mandibular fracturepain model.Methods: A total of 63 adult patients with mandibular fractures who were scheduled to undergo maxillofacial surgery were randomly allocatedto receive etoricoxib 90 mg, etoricoxib 120 mg and a placebo 1 hour before the surgery. Patients were followed-up till 24 hours after the surgery.Duration of analgesia, intra-operative and post-operative analgesic requirement, pain score, post-operative patient satisfaction and adverseeffects were measured.Results: The baseline demographic parameters were similar in all the groups. Duration of analgesia was longer in both the E120 (6.00±0.816hours) and E90 (4.37±1.008 hours) groups (p<0.05) as compared to the placebo group (2.60±0.821 hours). Mean difference of duration ofanalgesia between E120 and E90 was 1.62 (95% confidence interval: 0.234–3.484; p>0.05). Post-operative pain intensity was significantly lowerin both the E120 and E90 groups as compared to the C group. Both the etoricoxib groups required less intra-operative (p=0.002) and post-operative (p=0.001) analgesic supplementation as compared to the placebo group. The patient satisfaction score and rate of occurrence of significantadverse effects were similar among all the three groups.
Anahtar Kelime: Konular:
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
- 1. Kissin I. Preemptive analgesia. Anesthesiology 2000; 93: 1138- 43. [CrossRef]
- 2. Kissin I. Preemptive analgesia. Why its effect is not always obvious. Anaesthesiology 1996; 84: 1015-9. [CrossRef]
- 3. Crile GW. The kinetic theory of shock and its prevention through anoci-association. Lancet 1913; 182: 7-16. [CrossRef]
- 4. Woolf CJ, Chong MS. Preemptive analgesia-treating postoperative pain by preventing the establishment of central sensitization. Anesth Analg 1993; 77: 362-79. [CrossRef]
- 5. White PF. The role of non-opiod analgesic techniques in the management of pain after ambulatory surgery. Anesth Analg 2002; 94: 577-85. [CrossRef]
- 6. Vane JR, Botting RM. New insights into the mode of action of anti-inflammatory drugs. Inflamm Res 1995; 44: 1-10. [CrossRef]
- 7. Ekman EF, Wahba M, Ancona F. Analgesic efficacy of perioperative celecoxib in ambulatory arthroscopic knee surgery: a double-blind, placebo control study. Arthroscopy 2006; 22: 635- 42. [CrossRef]
- 8. Brooks P, Kubler P: Etoricoxib for arthritis and pain management. Ther Clin Risk Manag 2006; 2: 45-57.
- 9. Rasmussen GL, Malmstrom K, Bourne MH, Jove M, Rhondeau SM, Kotey P, et al. Etoricoxib Provides Analgesic Efficacy to Patients After Knee or Hip Replacement Surgery: A Randomized, Double-Blind, Placebo-Controlled Study. Anesth Analg 2005; 101: 1104-11. [CrossRef] 10. Purra A, Puolakka P, Rorarius M, Salmelin R, Lindgren L. Etoricoxib premedication for post-operative pain after laparoscopic cholecystectomy. Acta Anaesthesiol Scand 2006; 50: 688-93. [CrossRef] 11. Lierz P, Losch H, Felleiter P. Evaluation of a single preoperative dose of etoricoxib for postoperative pain relief in therapeutic knee arthroscopy: a randomized trial. Acta Orthop 2012; 83: 642-7. [CrossRef] 12. Daniels SE, Bandy DP, Christensen SE, Boice J, Losada MC, Liu H, et al. Evaluation of the dose range of etoricoxib in an acute pain setting using the postoperative dental pain model. Clin J Pain 2011; 27: 1-8. [CrossRef] 13. Chang DJ, Desjardins PJ, King TR, Erb T, Geba GP. The analgesic efficacy of etoricoxib compared with oxycodone/acetaminophen in an acute postoperative pain model: a randomized, double-blind clinical trial. Anesth Analg 2004; 99: 807-15. [CrossRef] 14. Nezafati S, Khiavi RK, Mirinejhad SS, Ammadi DA, Ghanizadeh M. Comparison of Pain Relief from Different Intravenous Doses of Ketorolac after Reduction of Mandibular Fractures. J Clin Diagn Res 2017; 11: PC06-PC10. [CrossRef] 15. Meric HJ. The effect of scale form choice on psychometric properties of patient satisfaction measurement. Health Mark Q 1994; 11: 27-39. [CrossRef] 16. Grape S, Tramer MR. Do we need preemptive analgesia for the treatment of postoperative pain? Best Pract Res Clin Anaesthesiol. 2007; 21: 51-63. [CrossRef] 17. Arendt-Nielsen L, Egsgaard LL, Petersen KK. Evidence for a central mode of action for etoricoxib (COX-2 inhibitor) in patients with painful knee osteoarthritis. Pain 2016; 157: 1634-44. [CrossRef] 18. Steffens JP, Santos FA, Sartori R, Pilatti GL. Preemptive dexamethasone and etoricoxib for pain and discomfort prevention after periodontal surgery: a double-masked, crossover, controlled clinical trial. J Periodontol 2010; 81: 1153- 60. [CrossRef] 19. Sharabi SE, Koshy JC, Thornton JF, Hollier LH Jr. Facial fractures. Plast Reconstr Surg 2011; 127: 25e-34. [CrossRef] 20. Srivastava S, Gupta D, Naz A, Rizvi MM, Singh PK. Effects of preoperative single dose Etoricoxib on postoperative pain and sleep after lumbar diskectomy: prospective randomized double blind controlled study. Middle East J Anaesthesiol 2012; 21: 725-30. 21. Clarke R, Derry S, Moore RA. Single dose oral etoricoxib for acute postoperative pain in adults.Cochrane Database Syst Rev 2014; 8: CD004309. [CrossRef] 22. Butts SC, Floyd E, Lai E, Rosenfeld RM, Doerr T. Reporting of Postoperative Pain Management Protocols in Randomized Clinical Trials of Mandibular Fracture Repair: A Systematic Review. JAMA Facial Plast Surg 2015; 17: 440-8. [CrossRef] 23. Nasser M, Pandis N, Fleming PS, Fedorowicz Z, Ellis E, Ali K. Interventions for the management of mandibular fractures. Cochrane Database Syst Rev 2013; 8: CD006087. [CrossRef] 24. Malmstrom K, Sapre A, Couglin H, Agrawal NGB, Mazenko RS, Fricke JR. Etoricoxib in acute pain associated with dental surgery: a randomized, double-blind, placebo- and active comparator-controlled dose-ranging study. Clin Ther 2004; 26: 667-79. [CrossRef]
| APA | GOSWAMI D, sardar a, BAIDYA D, Yadav D, BHUTIA O, ROYCHOUDHURY A (2020). Comparative Evaluation of Two Doses of Etoricoxib (90 mg and 120 mg) as PreEmptive Analgesic for Post-Operative Pain Relief in Mandibular Fracture Surgery Under General Anaesthesia: A Prospective, Randomised, Double-Blinded, PlaceboControlled Trial. , 24 - 30. 10.5152/TJAR.2019.54614 |
| Chicago | GOSWAMI Devalina,sardar arijit,BAIDYA Dalim Kumar,Yadav Dr. Rahul,BHUTIA Ongkila,ROYCHOUDHURY Ajoy Comparative Evaluation of Two Doses of Etoricoxib (90 mg and 120 mg) as PreEmptive Analgesic for Post-Operative Pain Relief in Mandibular Fracture Surgery Under General Anaesthesia: A Prospective, Randomised, Double-Blinded, PlaceboControlled Trial. (2020): 24 - 30. 10.5152/TJAR.2019.54614 |
| MLA | GOSWAMI Devalina,sardar arijit,BAIDYA Dalim Kumar,Yadav Dr. Rahul,BHUTIA Ongkila,ROYCHOUDHURY Ajoy Comparative Evaluation of Two Doses of Etoricoxib (90 mg and 120 mg) as PreEmptive Analgesic for Post-Operative Pain Relief in Mandibular Fracture Surgery Under General Anaesthesia: A Prospective, Randomised, Double-Blinded, PlaceboControlled Trial. , 2020, ss.24 - 30. 10.5152/TJAR.2019.54614 |
| AMA | GOSWAMI D,sardar a,BAIDYA D,Yadav D,BHUTIA O,ROYCHOUDHURY A Comparative Evaluation of Two Doses of Etoricoxib (90 mg and 120 mg) as PreEmptive Analgesic for Post-Operative Pain Relief in Mandibular Fracture Surgery Under General Anaesthesia: A Prospective, Randomised, Double-Blinded, PlaceboControlled Trial. . 2020; 24 - 30. 10.5152/TJAR.2019.54614 |
| Vancouver | GOSWAMI D,sardar a,BAIDYA D,Yadav D,BHUTIA O,ROYCHOUDHURY A Comparative Evaluation of Two Doses of Etoricoxib (90 mg and 120 mg) as PreEmptive Analgesic for Post-Operative Pain Relief in Mandibular Fracture Surgery Under General Anaesthesia: A Prospective, Randomised, Double-Blinded, PlaceboControlled Trial. . 2020; 24 - 30. 10.5152/TJAR.2019.54614 |
| IEEE | GOSWAMI D,sardar a,BAIDYA D,Yadav D,BHUTIA O,ROYCHOUDHURY A "Comparative Evaluation of Two Doses of Etoricoxib (90 mg and 120 mg) as PreEmptive Analgesic for Post-Operative Pain Relief in Mandibular Fracture Surgery Under General Anaesthesia: A Prospective, Randomised, Double-Blinded, PlaceboControlled Trial." , ss.24 - 30, 2020. 10.5152/TJAR.2019.54614 |
| ISNAD | GOSWAMI, Devalina vd. "Comparative Evaluation of Two Doses of Etoricoxib (90 mg and 120 mg) as PreEmptive Analgesic for Post-Operative Pain Relief in Mandibular Fracture Surgery Under General Anaesthesia: A Prospective, Randomised, Double-Blinded, PlaceboControlled Trial". (2020), 24-30. https://doi.org/10.5152/TJAR.2019.54614 |
| APA | GOSWAMI D, sardar a, BAIDYA D, Yadav D, BHUTIA O, ROYCHOUDHURY A (2020). Comparative Evaluation of Two Doses of Etoricoxib (90 mg and 120 mg) as PreEmptive Analgesic for Post-Operative Pain Relief in Mandibular Fracture Surgery Under General Anaesthesia: A Prospective, Randomised, Double-Blinded, PlaceboControlled Trial. Turkish Journal of Anaesthesiology and Reanimation, 48(1), 24 - 30. 10.5152/TJAR.2019.54614 |
| Chicago | GOSWAMI Devalina,sardar arijit,BAIDYA Dalim Kumar,Yadav Dr. Rahul,BHUTIA Ongkila,ROYCHOUDHURY Ajoy Comparative Evaluation of Two Doses of Etoricoxib (90 mg and 120 mg) as PreEmptive Analgesic for Post-Operative Pain Relief in Mandibular Fracture Surgery Under General Anaesthesia: A Prospective, Randomised, Double-Blinded, PlaceboControlled Trial. Turkish Journal of Anaesthesiology and Reanimation 48, no.1 (2020): 24 - 30. 10.5152/TJAR.2019.54614 |
| MLA | GOSWAMI Devalina,sardar arijit,BAIDYA Dalim Kumar,Yadav Dr. Rahul,BHUTIA Ongkila,ROYCHOUDHURY Ajoy Comparative Evaluation of Two Doses of Etoricoxib (90 mg and 120 mg) as PreEmptive Analgesic for Post-Operative Pain Relief in Mandibular Fracture Surgery Under General Anaesthesia: A Prospective, Randomised, Double-Blinded, PlaceboControlled Trial. Turkish Journal of Anaesthesiology and Reanimation, vol.48, no.1, 2020, ss.24 - 30. 10.5152/TJAR.2019.54614 |
| AMA | GOSWAMI D,sardar a,BAIDYA D,Yadav D,BHUTIA O,ROYCHOUDHURY A Comparative Evaluation of Two Doses of Etoricoxib (90 mg and 120 mg) as PreEmptive Analgesic for Post-Operative Pain Relief in Mandibular Fracture Surgery Under General Anaesthesia: A Prospective, Randomised, Double-Blinded, PlaceboControlled Trial. Turkish Journal of Anaesthesiology and Reanimation. 2020; 48(1): 24 - 30. 10.5152/TJAR.2019.54614 |
| Vancouver | GOSWAMI D,sardar a,BAIDYA D,Yadav D,BHUTIA O,ROYCHOUDHURY A Comparative Evaluation of Two Doses of Etoricoxib (90 mg and 120 mg) as PreEmptive Analgesic for Post-Operative Pain Relief in Mandibular Fracture Surgery Under General Anaesthesia: A Prospective, Randomised, Double-Blinded, PlaceboControlled Trial. Turkish Journal of Anaesthesiology and Reanimation. 2020; 48(1): 24 - 30. 10.5152/TJAR.2019.54614 |
| IEEE | GOSWAMI D,sardar a,BAIDYA D,Yadav D,BHUTIA O,ROYCHOUDHURY A "Comparative Evaluation of Two Doses of Etoricoxib (90 mg and 120 mg) as PreEmptive Analgesic for Post-Operative Pain Relief in Mandibular Fracture Surgery Under General Anaesthesia: A Prospective, Randomised, Double-Blinded, PlaceboControlled Trial." Turkish Journal of Anaesthesiology and Reanimation, 48, ss.24 - 30, 2020. 10.5152/TJAR.2019.54614 |
| ISNAD | GOSWAMI, Devalina vd. "Comparative Evaluation of Two Doses of Etoricoxib (90 mg and 120 mg) as PreEmptive Analgesic for Post-Operative Pain Relief in Mandibular Fracture Surgery Under General Anaesthesia: A Prospective, Randomised, Double-Blinded, PlaceboControlled Trial". Turkish Journal of Anaesthesiology and Reanimation 48/1 (2020), 24-30. https://doi.org/10.5152/TJAR.2019.54614 |
