Yıl: 2019 Cilt: 9 Sayı: 1 Sayfa Aralığı: 34 - 38 Metin Dili: İngilizce DOI: 10.5505/kjms.2019.37167 İndeks Tarihi: 22-05-2020

Previous Antibiotic Use and Its Influence on Antifungal Susceptibility of Candida Strains

Öz:
Aim: Antifungal drug resistance of Candida strains is a cause ofrecurrent or persistent vulvovaginal candidiasis (VVC). In order toprevent patient discomfort and to diminish the treatment cost ofthe disease, it is essential to identify the causative strain, determine the drug resistance status, and understand the mechanismof resistance.Material and Method: Vaginal discharge specimens were collected from 300 patients. Sixty-five Candida albicans and thirtyfive non-albicans species were identified. The susceptibility tovoriconazole, fluconazole, and amphotericin-B was examined.Previous antibiotic use and its correlation with the antifungal drugresistance were studied.Results: Fluconazole, voriconazole and amphotericin-B susceptibilities of Candida albicans strains were 92.3%, 86.2%, and 100%respectively. The non-albicans group’s susceptibilities to these antifungals were 45.7%, 22.9%, and 85.7% respectively (p=0.00 for all).After nitroimidazole use, 92.8% of infections were caused by Candidaalbicans, and 7.2% of them non-albicans strains (p=0.01). All the infections occurred after macrolide use was non-albicans infections(100%). There were no detected candida albicans infections (p=0.01).Conclusion: Since resistance to voriconazole, fluconazole, andamphotericin-B was more frequent in the non-albicans group,physicians should suspect from non-albicans strains for treatmentresistant VVC cases. Previous antibiotic use have not increasedthe amphotericin B, fluconazole and voriconazole resistance ofboth candida albicans and non-albicans strains. Recurrent infections which have no response to amphotericin B, fluconazole orvoriconazole treatment may be due to a different mechanism otherthan antifungal resistance of Candida species. The decreasedamount of lactobacilli in vaginal flora might be the reason for recurrent VVC.
Anahtar Kelime:

Candida Türlerinin Antifungal Duyarlılığında Önceki Antibiyotik Kullanımının Önem

Öz:
Amaç: Candida suşlarının antifungal ilaç direnci, tekrarlayan veya inatçı vulvovajinal kandidiyazın (VVC) bir nedenidir. Hastanın rahatsızlığını ve tekrarlayan VVC’nin ekonomik maliyetini önlemek için, nedensel suşu belirlemek, ilaç direnci durumunu belirlemek ve direnç mekanizmasını anlamak önemlidir. Materyal ve Metot: Vajinal akıntı örnekleri 300 hastadan toplanmış, 65 Candida albicans ve 35 non albicans türü tespit edilmiş, vorikonazol, flukonazol ve amfoterisin B’ye duyarlılık araştırılmıştır. Önceki antibiyotik kullanımı ve suşların antifungal ilaç direnci ile ilişkisi araştırılmıştır. Bulgular: Candida albicans suşlarının flukonazol, vorikonazol ve amfoterisin B duyarlılıkları %92,3, %86,2 ve %100 iken, nonalbicans grubunun bu antifungallere olan duyarlılıkları %45,7, %22,9 ve %85,7 idi (hepsi için p=0,00). Nitroimidazol kullanımından sonra, enfeksiyonların %92,8’ine candida albicans, %7,2’sinin non-albicans suşları neden olmuştur (p=0,01). Makrolid kullanımından sonra ortaya çıkan tüm enfeksiyonların tamamında nonalbicans türleri enfeksiyona neden olurken (%100) ve candida albicans nedenli enfeksiyon saptanmadı (p=0,01). Sonuç: Non-albicans grubunda vorikonazole, flukonazol ve amfoterisin B direnci daha sık olduğu için olduğu için, tedaviye dirençli VVC olgularında klinisyenler non albicans suşlarından şüphelenmelidir. Önceki antibiyotik kullanımı, hem candida albicans hem de albicans olmayan suşların amfoterisin B, flukonazol ve vorikonazol direncini arttırmamaktadır. Amfoterisin B, flukonazol veya vorikonazol tedavisine cevap vermeyen tekrarlayan enfeksiyonlar, kandida türlerinin antifungal direncinden farklı bir mekanizmaya bağlı olabilir. Vajinal florada azalmış laktobasil miktarı rekürren VVC’nin nedeni olabilir.
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Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
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APA Aslancan R, ELLİBEŞ KAYA A, Caliskan E (2019). Previous Antibiotic Use and Its Influence on Antifungal Susceptibility of Candida Strains. , 34 - 38. 10.5505/kjms.2019.37167
Chicago Aslancan Reyhan,ELLİBEŞ KAYA AŞKI,Caliskan Eray Previous Antibiotic Use and Its Influence on Antifungal Susceptibility of Candida Strains. (2019): 34 - 38. 10.5505/kjms.2019.37167
MLA Aslancan Reyhan,ELLİBEŞ KAYA AŞKI,Caliskan Eray Previous Antibiotic Use and Its Influence on Antifungal Susceptibility of Candida Strains. , 2019, ss.34 - 38. 10.5505/kjms.2019.37167
AMA Aslancan R,ELLİBEŞ KAYA A,Caliskan E Previous Antibiotic Use and Its Influence on Antifungal Susceptibility of Candida Strains. . 2019; 34 - 38. 10.5505/kjms.2019.37167
Vancouver Aslancan R,ELLİBEŞ KAYA A,Caliskan E Previous Antibiotic Use and Its Influence on Antifungal Susceptibility of Candida Strains. . 2019; 34 - 38. 10.5505/kjms.2019.37167
IEEE Aslancan R,ELLİBEŞ KAYA A,Caliskan E "Previous Antibiotic Use and Its Influence on Antifungal Susceptibility of Candida Strains." , ss.34 - 38, 2019. 10.5505/kjms.2019.37167
ISNAD Aslancan, Reyhan vd. "Previous Antibiotic Use and Its Influence on Antifungal Susceptibility of Candida Strains". (2019), 34-38. https://doi.org/10.5505/kjms.2019.37167
APA Aslancan R, ELLİBEŞ KAYA A, Caliskan E (2019). Previous Antibiotic Use and Its Influence on Antifungal Susceptibility of Candida Strains. Kafkas Tıp Bilimleri Dergisi, 9(1), 34 - 38. 10.5505/kjms.2019.37167
Chicago Aslancan Reyhan,ELLİBEŞ KAYA AŞKI,Caliskan Eray Previous Antibiotic Use and Its Influence on Antifungal Susceptibility of Candida Strains. Kafkas Tıp Bilimleri Dergisi 9, no.1 (2019): 34 - 38. 10.5505/kjms.2019.37167
MLA Aslancan Reyhan,ELLİBEŞ KAYA AŞKI,Caliskan Eray Previous Antibiotic Use and Its Influence on Antifungal Susceptibility of Candida Strains. Kafkas Tıp Bilimleri Dergisi, vol.9, no.1, 2019, ss.34 - 38. 10.5505/kjms.2019.37167
AMA Aslancan R,ELLİBEŞ KAYA A,Caliskan E Previous Antibiotic Use and Its Influence on Antifungal Susceptibility of Candida Strains. Kafkas Tıp Bilimleri Dergisi. 2019; 9(1): 34 - 38. 10.5505/kjms.2019.37167
Vancouver Aslancan R,ELLİBEŞ KAYA A,Caliskan E Previous Antibiotic Use and Its Influence on Antifungal Susceptibility of Candida Strains. Kafkas Tıp Bilimleri Dergisi. 2019; 9(1): 34 - 38. 10.5505/kjms.2019.37167
IEEE Aslancan R,ELLİBEŞ KAYA A,Caliskan E "Previous Antibiotic Use and Its Influence on Antifungal Susceptibility of Candida Strains." Kafkas Tıp Bilimleri Dergisi, 9, ss.34 - 38, 2019. 10.5505/kjms.2019.37167
ISNAD Aslancan, Reyhan vd. "Previous Antibiotic Use and Its Influence on Antifungal Susceptibility of Candida Strains". Kafkas Tıp Bilimleri Dergisi 9/1 (2019), 34-38. https://doi.org/10.5505/kjms.2019.37167