The areas of Public Relations and Social Work Act within the framework of activities aimed at generating public and individual benefits. In the context of their social consequences, their mediating structural transformations in many areas, bringing together the individuals who make up the society with a sense of trust, and acquiring ethical, moral and beneficial elements as guides can be considered as common points. The concepts of individual and Social Responsibility and entrepreneurship are the elements aimed at creating intellectual awareness on the target groups of Public Relations and Social Work areas, and to bring out the individual and public benefit with their action dimension. The awareness of individual social responsibility based on volunteerism, which has become widespread especially through the active roles of young people in social responsibility projects, brings with it the positive impact that is moving from individual to society. A similar assessment can be made on the basis of innovation, creativity, individual and social benefit through the concept of entrepreneurship. The aim of this study is to evaluate the relationship between individual social responsibility levels and entrepreneurial potential of university students studying in public relations and advertising department and Social Work departments in field interest. The survey method, one of the quantitative research methods, was used in the research. With the analysis of the data obtained through the survey, 6 hypotheses of the study were tested. As a result of the comparative evaluation of the relationship between social responsibility and entrepreneurship based on the department, it is envisaged that the individual and Social Responsibility and entrepreneurship levels of the students of the Department of Social Work differ from those of the Department of Public Relations because of some characteristics of the fields. In this respect, it is thought that the research will contribute to social work and Public Relations field literature.