The Course of Renal Functions in COPD. Two Statition: Exacerbation and Stable Period
Yıl: 2019 Cilt: 21 Sayı: 1 Sayfa Aralığı: 63 - 68 Metin Dili: İngilizce DOI: 10.4103/ejop.ejop_28_19 İndeks Tarihi: 27-03-2020
The Course of Renal Functions in COPD. Two Statition: Exacerbation and Stable Period
Öz: OBJECTIVE: Comorbidities in chronic obstructive pulmonary disease (COPD) are important factorsthat determine the prognosis of the disease. However, there are few studies about renal dysfunction.We aimed to compare the renal functions in COPD patients with stable and exacerbation periodsand to determine the frequency of acute renal failure (ARF) during exacerbation.MATERIALS AND METHODS: The files of 320 patients with COPD (forced expiratory volume in1 s/forced vital capacity <70% in pulmonary function test) who were admitted to our hospital between2015 and 2016 were evaluated retrospectively. After exclusion criteria, 113 patients were includedin the study. Data were analyzed by appropriate statistical method.RESULTS: Ninety (80.4%) of the patients were male and 23 (19.6%) were female. In the exacerbationperiod, blood urea nitrogen (P < 0.001), creatinine (P < 0.001), white blood cell (P < 0.001), C‑reactiveprotein (P < 0.001), and sedimentation (P < 0.001) were higher than that in the stable period.Furthermore, hemoglobin (P = 0.021) and estimated glomerular filtration rate (eGFR) (P < 0.001)were significantly lower. The number of emergency department admission in patients with eGFR<60 ml/min during the exacerbation more than the patients with eGFR ≥60 ml/min. Twenty (17.7%)patients have developed ARF during exacerbation (eGFR <60 ml/min).CONCLUSION: In COPD exacerbation period, kidney function is affected negatively in mostpatients (even if it does not reach the ABY border) and tends to improve in the stable period. Inpatients with COPD, it is thought that the causes of respiratory failure negatively affect renal function.
Anahtar Kelime: Konular:
Belge Türü: Makale Makale Türü: Araştırma Makalesi Erişim Türü: Erişime Açık
- Doktor Akçiçek Devlet Hastanesi, Göğüs Hatalıkları Bölümü, Kuzey Kıbrıs1. World Health Organization. Chronic Obstructive Pulmonary Disease (COPD). World Health Organization; 2014. Available from: http://www.who.int/respiratory/copd/en/. [Last accessed on 2014 Jul 23].
- 2. Halbert RJ, Natoli JL, Gano A, Badamgarav E, Buist AS, Mannino DM. Global burden of COPD: Systematic review and meta‑analysis. Eur Respir J 2006;28:523‑32.
- 3. Global Strategy for the Diagnosis. Management and Prevention of COPD, Global Initiative for Chronic Obstructive Lung Disease (GOLD); 2017. Available from: http://www.goldcopd.org. [Last accessed on 2017 Sep 12].
- 4. Lim WS, van der Eerden MM, Laing R, Boersma WG, Karalus N, Town GI, et al. Defining community acquired pneumonia severity on presentation to hospital: An international derivation and validation study. Thorax 2003;58:377‑82.
- 5. Palange P. Renal and hormonal abnormalities in chronic obstructive pulmonary disease (COPD). Thorax 1998;53:989‑91.
- 6. Miller MR, Crapo R, Hankinson J, Brusasco V, Burgos F, Casaburi R, et al. General considerations for lung function testing. Eur Respir J 2005;26:153‑61.
- 7. Global Strategy for the Diagnosis, Management and Prevention of COPD, Global Initiative for Chronic Obstructive Lung Disease (GOLD). 2011 revision. Available from: http://www.goldcopd. org/. [Last accessed on 2017 Sep 12].
- 8. Cockcroft DW, Gault MH. Prediction of creatinine clearance from serum creatinine. Nephron 1976;16:31‑41.
- 9. Barakat MF, McDonald HI, Collier TJ, Smeeth L, Nitsch D, Quint JK. Acute kidney injury in stable COPD and at exacerbation. Int J Chron Obstruct Pulmon Dis 2015;10:2067‑77.
- 10. Chen CY, Liao KM. Chronic obstructive pulmonary disease is associated with risk of chronic kidney disease: A Nationwide Case‑Cohort Study. Sci Rep 2016;6:25855.
- 11. Incalzi RA, Corsonello A, Pedone C, Battaglia S, Paglino G, Bellia V, et al. Chronic renal failure: A neglected comorbidity of COPD. Chest 2010;137:831‑7.
- 12. Gjerde B, Bakke PS, Ueland T, Hardie JA, Eagan TM. The prevalence of undiagnosed renal failure in a cohort of COPD patients in Western Norway. Respir Med 2012;106:361‑6.
- 13. Hallan SI, Dahl K, Oien CM, Grootendorst DC, Aasberg A, Holmen J, et al. Screening strategies for chronic kidney disease in the general population: Follow‑up of cross sectional health survey. BMJ 2006;333:1047.
- 14. Teruel JL, Sabater J, Galeano C, Rivera M, Merino JL, Fernández Lucas M, et al. The Cockcroft‑Gault equation is better than MDRD equation to estimate the glomerular filtration rate in patients with advanced chronic renal failure. Nefrologia 2007;27:313‑9.
- 15. Leonard CE, Freeman CP, Newcomb CW, Reese PP, Herlim M, Bilker WB, et al. Proton pump inhibitors and traditional nonsteroidal anti‑inflammatory drugs and the risk of acute interstitial nephritis and acute kidney injury. Pharmacoepidemiol Drug Saf 2012;21:1155‑72.
| APA | demir baha a, Ogan N, AKPINAR E, ateş c, Gulhan M (2019). The Course of Renal Functions in COPD. Two Statition: Exacerbation and Stable Period. , 63 - 68. 10.4103/ejop.ejop_28_19 |
| Chicago | demir baha ayse,Ogan Nalan,AKPINAR Evrim Eylem,ateş can,Gulhan Meral The Course of Renal Functions in COPD. Two Statition: Exacerbation and Stable Period. (2019): 63 - 68. 10.4103/ejop.ejop_28_19 |
| MLA | demir baha ayse,Ogan Nalan,AKPINAR Evrim Eylem,ateş can,Gulhan Meral The Course of Renal Functions in COPD. Two Statition: Exacerbation and Stable Period. , 2019, ss.63 - 68. 10.4103/ejop.ejop_28_19 |
| AMA | demir baha a,Ogan N,AKPINAR E,ateş c,Gulhan M The Course of Renal Functions in COPD. Two Statition: Exacerbation and Stable Period. . 2019; 63 - 68. 10.4103/ejop.ejop_28_19 |
| Vancouver | demir baha a,Ogan N,AKPINAR E,ateş c,Gulhan M The Course of Renal Functions in COPD. Two Statition: Exacerbation and Stable Period. . 2019; 63 - 68. 10.4103/ejop.ejop_28_19 |
| IEEE | demir baha a,Ogan N,AKPINAR E,ateş c,Gulhan M "The Course of Renal Functions in COPD. Two Statition: Exacerbation and Stable Period." , ss.63 - 68, 2019. 10.4103/ejop.ejop_28_19 |
| ISNAD | demir baha, ayse vd. "The Course of Renal Functions in COPD. Two Statition: Exacerbation and Stable Period". (2019), 63-68. https://doi.org/10.4103/ejop.ejop_28_19 |
| APA | demir baha a, Ogan N, AKPINAR E, ateş c, Gulhan M (2019). The Course of Renal Functions in COPD. Two Statition: Exacerbation and Stable Period. Eurasian Journal of Pulmonology, 21(1), 63 - 68. 10.4103/ejop.ejop_28_19 |
| Chicago | demir baha ayse,Ogan Nalan,AKPINAR Evrim Eylem,ateş can,Gulhan Meral The Course of Renal Functions in COPD. Two Statition: Exacerbation and Stable Period. Eurasian Journal of Pulmonology 21, no.1 (2019): 63 - 68. 10.4103/ejop.ejop_28_19 |
| MLA | demir baha ayse,Ogan Nalan,AKPINAR Evrim Eylem,ateş can,Gulhan Meral The Course of Renal Functions in COPD. Two Statition: Exacerbation and Stable Period. Eurasian Journal of Pulmonology, vol.21, no.1, 2019, ss.63 - 68. 10.4103/ejop.ejop_28_19 |
| AMA | demir baha a,Ogan N,AKPINAR E,ateş c,Gulhan M The Course of Renal Functions in COPD. Two Statition: Exacerbation and Stable Period. Eurasian Journal of Pulmonology. 2019; 21(1): 63 - 68. 10.4103/ejop.ejop_28_19 |
| Vancouver | demir baha a,Ogan N,AKPINAR E,ateş c,Gulhan M The Course of Renal Functions in COPD. Two Statition: Exacerbation and Stable Period. Eurasian Journal of Pulmonology. 2019; 21(1): 63 - 68. 10.4103/ejop.ejop_28_19 |
| IEEE | demir baha a,Ogan N,AKPINAR E,ateş c,Gulhan M "The Course of Renal Functions in COPD. Two Statition: Exacerbation and Stable Period." Eurasian Journal of Pulmonology, 21, ss.63 - 68, 2019. 10.4103/ejop.ejop_28_19 |
| ISNAD | demir baha, ayse vd. "The Course of Renal Functions in COPD. Two Statition: Exacerbation and Stable Period". Eurasian Journal of Pulmonology 21/1 (2019), 63-68. https://doi.org/10.4103/ejop.ejop_28_19 |
